Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Geraldine O'Sullivan-Coyne"'
Autor:
Arun Rajan, Christopher R. Heery, Anish Thomas, Andrew L. Mammen, Susan Perry, Geraldine O’Sullivan Coyne, Udayan Guha, Arlene Berman, Eva Szabo, Ravi A. Madan, Leomar Y. Ballester, Stefania Pittaluga, Renee N. Donahue, Yo-Ting Tsai, Lauren M. Lepone, Kevin Chin, Fiona Ginty, Anup Sood, Stephen M. Hewitt, Jeffrey Schlom, Raffit Hassan, James L. Gulley
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-12 (2019)
Abstract Background Thymic epithelial tumors are PD-L1–expressing tumors of thymic epithelial origin characterized by varying degrees of lymphocytic infiltration and a predisposition towards development of paraneoplastic autoimmunity. PD-1–target
Externí odkaz:
https://doaj.org/article/b66a3a1a163041f19fe2d792850a4a64
Autor:
James Nguyen, Naoko Takebe, Shivaani Kummar, Albiruni Razak, Sant P. Chawla, Suzanne George, Shreyaskumar R. Patel, Mary Louise Keohan, Sujana Movva, Geraldine O'Sullivan Coyne, Khanh Do, Lamin Juwara, Brooke Augustine, Seth M. Steinberg, Laura Kuhlmann, S. Percy Ivy, James H. Doroshow, Alice P. Chen
Publikováno v:
Clinical Cancer Research. 29:1200-1208
Purpose: Alveolar soft part sarcoma (ASPS) is a rare, highly vascular tumor with few treatment options. We designed a phase II randomized trial to determine the activity and tolerability of single-agent cediranib or sunitinib in patients with advance
Autor:
Apurva K. Srivastava, Ralph E. Parchment, James H. Doroshow, Brigitte C. Widemann, Alice P. Chen, Barry C. Johnson, Andrea M. Gross, Geraldine O'Sullivan Coyne, Dominic Esposito, Melinda G. Hollingshead, Casey L. Kilpatrick, William G. Herrick
This document includes Supplementary Methods, validation data (Figures S1 and S2), complete PD data sets (Figures S3-S7), and Supplementary Tables detailing statistical analyses and assay validation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2112c24bc490ca09fb4765d6616478c1
https://doi.org/10.1158/1535-7163.22520812.v1
https://doi.org/10.1158/1535-7163.22520812.v1
Autor:
Apurva K. Srivastava, Ralph E. Parchment, James H. Doroshow, Brigitte C. Widemann, Alice P. Chen, Barry C. Johnson, Andrea M. Gross, Geraldine O'Sullivan Coyne, Dominic Esposito, Melinda G. Hollingshead, Casey L. Kilpatrick, William G. Herrick
Ras/Raf/MEK/ERK (MAPK) and PI3K/AKT signaling pathways influence several cell functions involved in oncogenesis, making them attractive drug targets. We describe a novel multiplex immunoassay to quantitate isoform-specific phosphorylation of proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42c4c9076603dbbe6d0c3610e28659c6
https://doi.org/10.1158/1535-7163.c.6542791
https://doi.org/10.1158/1535-7163.c.6542791
Autor:
Alice P. Chen, James H. Doroshow, Ganesh Mugundu, Biswajit Das, Ting-Chia Chang, Li Chen, Ralph E. Parchment, Robert J. Kinders, Deborah Wilsker, Jiuping Ji, Sarah B. Miller, Arjun Mittra, Howard Streicher, Elad Sharon, Richard Piekarz, Larry Rubinstein, Jennifer Zlott, Lamin Juwara, Ashley Bruns, Khanh Do, Shivaani Kummar, Geraldine O'Sullivan Coyne, Abdul Rafeh Naqash, Naoko Takebe
Purpose:The Wee1 kinase inhibitor adavosertib abrogates cell-cycle arrest, leading to cell death. Prior testing of twice-daily adavosertib in patients with advanced solid tumors determined the recommended phase II dose (RPh2D). Here, we report result
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c8ae5c4e40d695b8ef0f809480cf004
https://doi.org/10.1158/1078-0432.c.6530684.v1
https://doi.org/10.1158/1078-0432.c.6530684.v1
Autor:
Alice P. Chen, James H. Doroshow, Ganesh Mugundu, Biswajit Das, Ting-Chia Chang, Li Chen, Ralph E. Parchment, Robert J. Kinders, Deborah Wilsker, Jiuping Ji, Sarah B. Miller, Arjun Mittra, Howard Streicher, Elad Sharon, Richard Piekarz, Larry Rubinstein, Jennifer Zlott, Lamin Juwara, Ashley Bruns, Khanh Do, Shivaani Kummar, Geraldine O'Sullivan Coyne, Abdul Rafeh Naqash, Naoko Takebe
Supplementary Methods, Supplementary Fig. S1 (Mean adavosertib plasma concentrations for QD vs. BID schedules), Supplementary Fig. S2 (Example PD biomarker immunofluorescence images), Supplementary Fig. S3 (CCNE1 tumor alteration frequency IMPACT dat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47a74ee9d08ad2a06e7e92b80d4c2a9a
https://doi.org/10.1158/1078-0432.22481402
https://doi.org/10.1158/1078-0432.22481402
Autor:
Alice P. Chen, James H. Doroshow, John J. Wright, Rene Costello, Donald Bottaro, Andrea Regier Voth, Naoko Takebe, Elad Sharon, Howard Streicher, Richard Piekarz, Robert Meehan, Lamin Juwara, Jared C. Foster, Lawrence Rubinstein, Ashley Bruns, Jennifer Zlott, Khanh T. Do, Warren A. Chow, Kristen Ganjoo, James Hu, Shivaani Kummar, Geraldine O'Sullivan Coyne
Supplementary Data from Clinical Activity of Single-Agent Cabozantinib (XL184), a Multi-receptor Tyrosine Kinase Inhibitor, in Patients with Refractory Soft-Tissue Sarcomas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18093bd7818563307195df58214a4506
https://doi.org/10.1158/1078-0432.22483926
https://doi.org/10.1158/1078-0432.22483926
Autor:
Alice P. Chen, James H. Doroshow, John J. Wright, Rene Costello, Donald Bottaro, Andrea Regier Voth, Naoko Takebe, Elad Sharon, Howard Streicher, Richard Piekarz, Robert Meehan, Lamin Juwara, Jared C. Foster, Lawrence Rubinstein, Ashley Bruns, Jennifer Zlott, Khanh T. Do, Warren A. Chow, Kristen Ganjoo, James Hu, Shivaani Kummar, Geraldine O'Sullivan Coyne
Purpose:Soft-tissue sarcomas (STS) are a rare, heterogeneous group of mesenchymal tumors. For decades the mainstay of treatment for advanced, unresectable STS has been palliative chemotherapy. High levels of activated MET receptor have been reported
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acae07441313ff191c17c7376293dd3a
https://doi.org/10.1158/1078-0432.c.6531276.v1
https://doi.org/10.1158/1078-0432.c.6531276.v1
PARP Inhibitor Applicability: Detailed Assays for Homologous Recombination Repair Pathway Components
Autor:
Geraldine, O'Sullivan Coyne, Chris, Karlovich, Deborah, Wilsker, Andrea Regier, Voth, Ralph E, Parchment, Alice P, Chen, James H, Doroshow
Publikováno v:
OncoTargets and Therapy. 15:165-180
Poly(ADP-ribose) polymerase inhibitors (PARPi) have been in clinical use since 2014 for certain patients with germline
Autor:
Robert S. Meehan, Ashley Bruns, Lamin Jawara, Geraldine O'Sullivan Coyne, James C. Hu, Naoko Takebe, Alice P. Chen, S. Kummar, Andrea Regier Voth, Jared C. Foster, Howard Streicher, Kristen N. Ganjoo, Khanh T. Do, Rene Costello, Elad Sharon, Jennifer Zlott, Larry Rubinstein, Donald P. Bottaro, Warren A. Chow, John Wright, Richard Piekarz, James H. Doroshow
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research, vol 28, iss 2
Clin Cancer Res
Clin Cancer Res
Purpose: Soft-tissue sarcomas (STS) are a rare, heterogeneous group of mesenchymal tumors. For decades the mainstay of treatment for advanced, unresectable STS has been palliative chemotherapy. High levels of activated MET receptor have been reported