Zobrazeno 1 - 10
of 249
pro vyhledávání: '"Geraldine O'Sullivan"'
Autor:
Arun Rajan, Christopher R. Heery, Anish Thomas, Andrew L. Mammen, Susan Perry, Geraldine O’Sullivan Coyne, Udayan Guha, Arlene Berman, Eva Szabo, Ravi A. Madan, Leomar Y. Ballester, Stefania Pittaluga, Renee N. Donahue, Yo-Ting Tsai, Lauren M. Lepone, Kevin Chin, Fiona Ginty, Anup Sood, Stephen M. Hewitt, Jeffrey Schlom, Raffit Hassan, James L. Gulley
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-12 (2019)
Abstract Background Thymic epithelial tumors are PD-L1–expressing tumors of thymic epithelial origin characterized by varying degrees of lymphocytic infiltration and a predisposition towards development of paraneoplastic autoimmunity. PD-1–target
Externí odkaz:
https://doaj.org/article/b66a3a1a163041f19fe2d792850a4a64
Autor:
AeRang Kim, Yao Lu, Scott H. Okuno, Denise Reinke, Ophélia Maertens, John Perentesis, Mitali Basu, Pamela L. Wolters, Thomas De Raedt, Sant Chawla, Rashmi Chugh, Brian A. Van Tine, Geraldine O’Sullivan, Alice Chen, Karen Cichowski, Brigitte C. Widemann
Publikováno v:
Sarcoma, Vol 2020 (2020)
Purpose. Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive soft tissue sarcomas. Combining Hsp90 inhibitors to enhance endoplasmic reticulum stress with mTOR inhibition results in dramatic MPNST shrinkage in a genetically engineered MP
Externí odkaz:
https://doaj.org/article/1f1a358664ee478b94751c3fec57799c
Autor:
Geraldine O’Sullivan
Publikováno v:
Acta Medica Lituanica, Vol 19, Iss 3 (2012)
Hypertension is the most frequent medical complication of pregnancy. Pre-eclampsia is one of the main causes of maternal and fetal morbidity and mortality. Hypertension is the most common first sign of preeclampsia. Pre-eclampsia is also associated w
Externí odkaz:
https://doaj.org/article/61de9d2b4f44493a8a86dfccd3b01196
Akademický článek
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Akademický článek
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Autor:
Coyne, Geraldine O'Sullivan (AUTHOR), Karlovich, Chris (AUTHOR), Wilsker, Deborah (AUTHOR), Voth, Andrea Regier (AUTHOR), Parchment, Ralph E (AUTHOR), Chen, Alice P (AUTHOR), Doroshow, James H (AUTHOR)
Publikováno v:
OncoTargets & Therapy. Feb2022, Vol. 15, p165-180. 16p.
Autor:
James Nguyen, Naoko Takebe, Shivaani Kummar, Albiruni Razak, Sant P. Chawla, Suzanne George, Shreyaskumar R. Patel, Mary Louise Keohan, Sujana Movva, Geraldine O'Sullivan Coyne, Khanh Do, Lamin Juwara, Brooke Augustine, Seth M. Steinberg, Laura Kuhlmann, S. Percy Ivy, James H. Doroshow, Alice P. Chen
Publikováno v:
Clinical Cancer Research. 29:1200-1208
Purpose: Alveolar soft part sarcoma (ASPS) is a rare, highly vascular tumor with few treatment options. We designed a phase II randomized trial to determine the activity and tolerability of single-agent cediranib or sunitinib in patients with advance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed830b53ecb0a730e3001c430b8fc8da
https://doi.org/10.1158/1078-0432.ccr-22-2145
https://doi.org/10.1158/1078-0432.ccr-22-2145
Autor:
Apurva K. Srivastava, Ralph E. Parchment, James H. Doroshow, Brigitte C. Widemann, Alice P. Chen, Barry C. Johnson, Andrea M. Gross, Geraldine O'Sullivan Coyne, Dominic Esposito, Melinda G. Hollingshead, Casey L. Kilpatrick, William G. Herrick
This document includes Supplementary Methods, validation data (Figures S1 and S2), complete PD data sets (Figures S3-S7), and Supplementary Tables detailing statistical analyses and assay validation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2112c24bc490ca09fb4765d6616478c1
https://doi.org/10.1158/1535-7163.22520812.v1
https://doi.org/10.1158/1535-7163.22520812.v1
Autor:
Apurva K. Srivastava, Ralph E. Parchment, James H. Doroshow, Brigitte C. Widemann, Alice P. Chen, Barry C. Johnson, Andrea M. Gross, Geraldine O'Sullivan Coyne, Dominic Esposito, Melinda G. Hollingshead, Casey L. Kilpatrick, William G. Herrick
Ras/Raf/MEK/ERK (MAPK) and PI3K/AKT signaling pathways influence several cell functions involved in oncogenesis, making them attractive drug targets. We describe a novel multiplex immunoassay to quantitate isoform-specific phosphorylation of proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42c4c9076603dbbe6d0c3610e28659c6
https://doi.org/10.1158/1535-7163.c.6542791
https://doi.org/10.1158/1535-7163.c.6542791
Autor:
Alice P. Chen, James H. Doroshow, Ganesh Mugundu, Biswajit Das, Ting-Chia Chang, Li Chen, Ralph E. Parchment, Robert J. Kinders, Deborah Wilsker, Jiuping Ji, Sarah B. Miller, Arjun Mittra, Howard Streicher, Elad Sharon, Richard Piekarz, Larry Rubinstein, Jennifer Zlott, Lamin Juwara, Ashley Bruns, Khanh Do, Shivaani Kummar, Geraldine O'Sullivan Coyne, Abdul Rafeh Naqash, Naoko Takebe
Purpose:The Wee1 kinase inhibitor adavosertib abrogates cell-cycle arrest, leading to cell death. Prior testing of twice-daily adavosertib in patients with advanced solid tumors determined the recommended phase II dose (RPh2D). Here, we report result
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c8ae5c4e40d695b8ef0f809480cf004
https://doi.org/10.1158/1078-0432.c.6530684.v1
https://doi.org/10.1158/1078-0432.c.6530684.v1