Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Geraldine M. O'Connor"'
Autor:
Geraldine M. O’Connor, Emyr Y. Bakker
Publikováno v:
BioMedInformatics, Vol 2, Iss 4, Pp 580-592 (2022)
Immune checkpoint blockade targeting PDCD1 (PD-1) or CD274 (PD-L1) has demonstrated efficacy and interest across multiple cancers. However, the exact determinants of the response and cancer-specific molecular features remain unclear. A recent pan-can
Externí odkaz:
https://doaj.org/article/1db88d5d8d8945e8afdc921aace68f0b
Autor:
Shoeib Moradi, Sanda Stankovic, Geraldine M. O’Connor, Phillip Pymm, Bruce J. MacLachlan, Camilla Faoro, Christelle Retière, Lucy C. Sullivan, Philippa M. Saunders, Jacqueline Widjaja, Shea Cox-Livingstone, Jamie Rossjohn, Andrew G. Brooks, Julian P. Vivian
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
KIR2DL2 and KIR2DL3 are two inhibitory members of the killer-cell immunoglobulin-like receptors (KIR) family that share a common HLA-I preference in binding HLA from the C1 group. However, it is still unclear to what extent binding and function is eq
Externí odkaz:
https://doaj.org/article/2e2f5009dd934a8381838529885caa65
Autor:
Peter Bardy, Lucy C. Sullivan, Anthony P. Schwarer, Uwe Hahn, Charles G. Mullighan, Kathleen Doherty, Geraldine M. O’Connor, Silke Danner, Jeff Szer, Susan L. Heatley, Andrew G. Brooks, Kenneth F. Bradstock
Publikováno v:
HLA. 92:74-82
Natural killer cells are thought to influence the outcome of hematopoietic stem cell transplant (HSCT), impacting on relapse, overall survival, graft versus host disease and the control of infection, in part through the complex interplay between the
Autor:
Corinne R Hitchen, David Price, Gabriella Pietra, Geraldine M. O’Connor, Andrew G. Brooks, Jamie Rossjohn, Fabrizio Loiacono, Lorenzo Moretta, Victoria A Hughes, Michela Falco, Maria Cristina Mingari, Jacqueline M.L. Widjaja, Phillip Pymm, Philippa M. Saunders, Daniel W. McVicar, Julian P. Vivian
Publikováno v:
The Journal of Experimental Medicine
Rossjohn, Brooks, Vivian, and colleagues provide the most complete picture to date of the impact of KIR3DL1 polymorphism on HLA class I recognition, which can be used to both reevaluate previous work on the involvement of KIR3DL1 in disease as well a
Autor:
Daniel W. McVicar, Geraldine M. O’Connor, Maureen P. Martin, Sara Cristina Lobo-Alves, Maria Luiza Petzl-Erler, Danillo G. Augusto, Mary Carrington, Sara Bass
Publikováno v:
European Journal of Immunology. 45:2052-2060
Although HLA-A3 and A11 have been reported to be ligands for KIR3DL2, evidence for any in vivo relevance of this interaction is still missing. To explore the functional importance of KIR3DL2 allelic variation, we analyzed the autoimmune disease pemph
Autor:
Geraldine M, O'Connor, Julian P, Vivian, Emma, Gostick, Phillip, Pymm, Bernard A P, Lafont, David A, Price, Jamie, Rossjohn, Andrew G, Brooks, Daniel W, McVicar
Publikováno v:
Journal of Virology
Killer cell immunoglobulin-like receptors (KIRs) play an important role in the activation of natural killer (NK) cells, which in turn contribute to the effective immune control of many viral infections. In the context of HIV infection, the closely re
Autor:
Jamie Rossjohn, Jacqueline M.L. Widjaja, Travis Clarke Beddoe, Geraldine M. O’Connor, Phillip Pymm, Philippa M. Saunders, Andrew G. Brooks, Stephanie Gras, Nikola Baschuk, Daniel M. Andrews, Daniel W. McVicar, Julian P. Vivian, Corinne R Hitchen
Publikováno v:
The Journal of Immunology. 194:781-789
The killer cell Ig-like receptor 3DL1 (KIR3DL1) inhibits activation of NK cells upon interaction with HLA class I molecules such as HLA-B*57:01, which contains the Bw4 epitope spanning residues 77–83 (e.g., NLRIALR), and not with HLA allomorphs tha
Autor:
Sri H. Ramarathinam, Patricia T. Illing, Andrew G. Brooks, Julian P. Vivian, Geraldine M. O’Connor, Corinne R Hitchen, Daniel W. McVicar, Victoria A Hughes, Bosco K. Ho, Phillip Pymm, David Price, Anthony W. Purcell, Jamie Rossjohn
Publikováno v:
Nat Struct Mol Biol
Major histocompatibility complex class I (MHC-I) molecules play a crucial role in immunity by capturing peptides for presentation to T cells and natural killer (NK) cells. The peptide termini are tethered within the MHC-I antigen-binding groove, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6918ba30441b4553c980cfcfa64b8b9a
Autor:
Bernice M. Benoit, Brian S. Kim, Junko Takeshita, Neha Jariwala, Alain H. Rook, Timothy M. Whelan, Christopher J. Miller, Daniel W. McVicar, Lisa Zhu, Maria Wysocka, Adrienne J Werth, Landon K. Oetjen, Andrea B. Troxel, Geraldine M. O’Connor, Hélène Sicard
Sezary syndrome (SS), a leukemic variant of cutaneous T-cell lymphoma (CTCL), is associated with a significantly shorter life expectancy compared to skin-restricted mycosis fungoides. Early diagnosis of SS is, therefore, key to achieving enhanced the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f88eaae25bd1a88fee8197b7648cf934
Autor:
Geraldine M. O’Connor, Hongchuan Li, Andrew Huehn, Sarah Cooley, Jeffrey S. Miller, Stephen K. Anderson, Paul W. Wright
Publikováno v:
Genes and immunity
Members of the human KIR (killer cell immunoglobulin-like receptor) class I major histocompatibility complex receptor gene family contain multiple promoters that determine the variegated expression of KIR on natural killer cells. In order to identify