Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Geraldine Kaeslin"'
Autor:
Geraldine Kaeslin, Manohar Salla, Janet C. Reid, Paul V. Bernhardt, Avril A. B. Robertson, Ruby Pelingon, Daniel E. Croker, Elizabeth M. J. Gillam, Mark S. Butler, Mark E. Cooper, Jong Min Baek
Publikováno v:
ACS Medicinal Chemistry Letters. 7:1034-1038
MCC950 is an orally bioavailable small molecule inhibitor of the NOD-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasome that exhibits remarkable activity in multiple models of inflammatory disease. Incubation of MCC950 with human li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3fbb01788df5c9fe4de18ac60e0dcb3
https://doi.org/10.1021/acsmedchemlett.6b00198
https://doi.org/10.1021/acsmedchemlett.6b00198
Autor:
Mark E. Cooper, Reena Halai, Trent M. Woodruff, Peter N. Monk, Daniel E. Croker, Christodoulos A. Floudas, Zoe Schofield, Geraldine Kaeslin, Mike Cl Wu, Richard J. Clark, Mark At Blaskovich, Dimitrios Morikis
Publikováno v:
Immunology & Cell Biology. 94:787-795
The complement cascade is comprised of a highly sophisticated network of innate immune proteins that are activated in response to invading pathogens or tissue injury. The complement activation peptide, C5a, binds two seven transmembrane receptors, na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37b8e227f6b17b83d148a607e9a967c6
https://doi.org/10.1038/icb.2016.43
https://doi.org/10.1038/icb.2016.43
Autor:
Carol Wicking, Milan Hiersche, Björn Hartleben, Walter Hunziker, Hao Lu, Peter Papathanasiou, Robert Tunningley, Shubha Vij, Friedhelm Hildebrandt, Valeska Frank, Heon Yung Gee, Graham D. Wright, Carsten Bergmann, Nadina Ortiz-Brüchle, Sudipto Roy, Klaus Zerres, Maria C. Rondón Galeano, Andrew C. Perkins, Nadescha Hilger, Melissa H. Little, Edgar A. Otto, Udo Vester, Daniel Epting, Elisabeth Ott, Elke Wühl, P. Jaya Kausalya, Vicki Metzis, Geraldine Kaeslin, Andrew D. Courtney, Belinda Whittle, Shang Yew Tay, Carina Kramer, Steffen Neuber
Autosomal recessive polycystic kidney disease (ARPKD), usually considered to be a genetically homogeneous disease caused by mutations in PKHD1, has been associated with ciliary dysfunction. Here, we describe mutations in DZIP1L, which encodes DAZ int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6dc29ffbf13e65bd4114bc34142261c
https://europepmc.org/articles/PMC5687889/
https://europepmc.org/articles/PMC5687889/
Autor:
Reena Halai, Andreas Klos, Elisabeth Wende, Peter N. Monk, Mark E. Cooper, Beate Fehlhaber, Daniel E. Croker, Geraldine Kaeslin
Publikováno v:
Immunology & Cell Biology. 92:631-639
The complement system is a major component of our innate immune system, in which the complement proteins C5a and C5a-des Arg bind to two G-protein-coupled receptors: namely, the C5a receptor (C5a1) and C5a receptor like-2 receptor (C5a2, formerly cal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c2805f7180ee4d8b06859a9cc2dd90c
https://doi.org/10.1038/icb.2014.32
https://doi.org/10.1038/icb.2014.32
Autor:
Mark A. T. Blaskovich, Miranda E. Pitt, K.C. Sanjaya, Geraldine Kaeslin, Mark S. Butler, Ruby Pelingon, Mark E. Cooper, Wanida Phetsang
Publikováno v:
ACS Infectious Diseases
Reduced susceptibility to antimicrobials in Gram-negative bacteria may result from multiple resistance mechanisms, including increased efflux pump activity or reduced porin protein expression. Up-regulation of the efflux pump system is closely associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b8e5e3eefc38ceee78af9a0ea2c55a4
https://pubmed.ncbi.nlm.nih.gov/27737551
https://pubmed.ncbi.nlm.nih.gov/27737551
Autor:
Geraldine Kaeslin, Anjan Debnath, Yukiko Miyamoto, Soumya Ramu, Tomislav Karoli, Alysha G. Elliott, Mark A. T. Blaskovich, Johnny X. Huang, Angie M. Jarrad, Chin Yen Tay, Mark E. Cooper, Johannes Zuegg, Angela M. Kavanagh, Lars Eckmann
Publikováno v:
European Journal of Medicinal Chemistry
Metronidazole has been used clinically for over 50 years as an antiparasitic and broad-spectrum antibacterial agent effective against anaerobic bacteria. However resistance to metronidazole in parasites and bacteria has been reported, and improved se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1eadec709ea3044fb6cdcf7ed8e7f7a
https://escholarship.org/uc/item/6gf4g1fh
https://escholarship.org/uc/item/6gf4g1fh
Autor:
Lawrence H. Lash, Mark S. Butler, Johnny X. Huang, Mark E. Cooper, Bernd Becker, Geraldine Kaeslin, Mark A. T. Blaskovich, Melissa H. Little, Max V. Ranall
Publikováno v:
Pharmacology Research & Perspectives
There has been intensive effort to identify in vivo biomarkers that can be used to monitor drug-induced kidney damage and identify injury before significant impairment occurs. Kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84d76290edb867ab2ed4a866b1397520
https://pubmed.ncbi.nlm.nih.gov/26171227
https://pubmed.ncbi.nlm.nih.gov/26171227
Autor:
Dimitrios Morikis, Reena Halai, Geraldine Kaeslin, Trent M. Woodruff, Christodoulos A. Floudas, Mark E. Cooper, Peter N. Monk, Daniel E. Croker
Publikováno v:
Cytokine. 70:35
Background The complement cascade is a highly sophisticated network of proteins that are well regulated and directed in response to invading pathogens or tissue injury and forms a major component of our innate immune response. Complement C5a binds to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2329ff06d179463ddd0bee75081ce1e0
https://doi.org/10.1016/j.cyto.2014.07.039
https://doi.org/10.1016/j.cyto.2014.07.039