Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Geraldine Hill"'
Publikováno v:
Bulletin of the World Health Organization, Vol 92, Iss 12, Pp 918-919 (2014)
Externí odkaz:
https://doaj.org/article/135cc0808a99496b8632bfd2bdda0285
Publikováno v:
Veins and Lymphatics, Vol 2, Iss 2, Pp e18-e18 (2013)
In the past the saphenofemoral junction (SFJ) for the surgeon was regarded as a simple conduit to be obliterated. With modern ultrasound we can distinguish the components of this complex structure and examine their haemodynamic function and suggest m
Externí odkaz:
https://doaj.org/article/bbfb23fc67ae43f280c8eaaef17d93d7
Autor:
Alex F. Nkayamba, Danstan H. Shewiyo, Alambo K. Mssusa, Adam M. Fimbo, Hiiti Baran Sillo, Omary Minzi, Henry Irunde, Geraldine Hill
Publikováno v:
Clinical Drug Investigation. 36:401-411
Artemisinin combination therapies such as artemether-lumefantrine (AL) are effective for first-line treatment of uncomplicated acute Plasmodium falciparum malaria. However, the safety profile of AL in large populations has not been fully assessed. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::253985423874aa99b4377b28cbfef3ac
https://doi.org/10.1007/s40261-016-0385-z
https://doi.org/10.1007/s40261-016-0385-z
Autor:
George Sabblah, Edward Abwao, Shanthi N. Pal, Adeline Osakwe, Alexander N. O. Dodoo, Jayesh Pandit, George Muthuri, Star Khoza, Priscilla P. Nyambayo, Mimi Darko, Cassandra Elagbaje, Comfort Kunak Suku, Geraldine Hill
Publikováno v:
Drug Safety
Introduction Cohort event monitoring (CEM) is an intensive method of post-marketing surveillance for medicines safety. The method is based on prescription event monitoring, which began in the 1970s, and has since been adapted by WHO for monitoring th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::165e5757182da1d98865a6814d125185
https://doi.org/10.1007/s40264-015-0331-7
https://doi.org/10.1007/s40264-015-0331-7
Autor:
Jianxia Shi, Xiaoning Zhao, Samer Chmait, Mary Dovlatyan, Silke Miller, Kristin L. Andrews, Geraldine Hill Della Puppa, James J. S. Treanor, Dianna Lester-Zeiner, Carl Davis, Essa Hu, Christopher Biorn, Jessica Able, Hang Chen, Jennifer R. Allen, Ji Ma
Publikováno v:
ACS Medicinal Chemistry Letters. 5:700-705
We report the discovery of novel imidazo[4,5-b]pyridines as potent and selective inhibitors of PDE10A. The investigation began with our recently disclosed ketobenzimidazole 1, which exhibited single digit nanomolar PDE10A activity but poor oral bioav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f48b3d8c765bcbadc35e47aee5474f6
https://doi.org/10.1021/ml5000993
https://doi.org/10.1021/ml5000993
Autor:
Dah-Ren Hwang, Geraldine Hill Della Puppa, Jamie Wong, Essa Hu, Thomas Nixey, Silke Miller, Hang Chen, Jessica Able, Dianna Lester-Zeiner, James J. S. Treanor, Robert Cho, Santosh Talreja, Roxanne Kunz, Jianxia Shi, Ji Ma, David C. Immke, Jennifer R. Allen, Christopher Biorn, Amy Porter, Klaus Michelsen, Shannon Rumfelt, Stephen Hitchcock
Publikováno v:
Journal of Medicinal Chemistry. 55:4776-4787
A radiolabeled tracer for imaging therapeutic targets in the brain is a valuable tool for lead optimization in CNS drug discovery and for dose selection in clinical development. We report the rapid identification of a novel phosphodiesterase 10A (PDE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::626c862c5f50bd2845e3c603ba24a357
https://doi.org/10.1021/jm3002372
https://doi.org/10.1021/jm3002372
Autor:
J. Richard Heys, Donna L. Maier, Mark E. Powell, Charles S. Elmore, Cindy Sobotka-Briner, Min Ding, Qiaoling Jiang, M. Edward Pierson, Geraldine Hill, Ladislav Mrzljak
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 330:342-351
Radiotracers suitable for positron emission tomography studies often serve as preclinical tools for in vivo receptor occupancy. The serotonin 1B receptor (5-HT(1B)) subtype is a pharmacological target used to discover treatments for various psychiatr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b44e96b2712d7ff87259f711e5c536f
https://doi.org/10.1124/jpet.109.150722
https://doi.org/10.1124/jpet.109.150722
Autor:
Ross A. Pettigrew, Stephen G. K. Packer, Mohammad A. Amer, Andre M. van Rij, B. Geraldine Hill, Ian Thomson, Gregory T. Jones
Publikováno v:
Circulation. 118:66-74
Background— Saphenofemoral junction (SFJ) ligation has been a major component of surgical intervention for varicose veins; however, recurrence occurs in as many as 40%. Neovascularization with reconnection of the venous channels at the transected S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6412f027d15a3d5abf7043bda0ee5cfb
https://doi.org/10.1161/circulationaha.107.726869
https://doi.org/10.1161/circulationaha.107.726869
Autor:
James J. S. Treanor, Jack C. Reidling, Silke Miller, Geraldine Hill Della Puppa, Edoardo Marcora, Leslie M. Thompson
Publikováno v:
Journal of Huntington's disease. 3(4)
Background Phosphodiesterase 10A (PDE10A) is expressed at high levels in the striatum and has been proposed both as a biomarker for Huntington's disease pathology and as a target for intervention. Objective PDE10A radiotracers have been successfully
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72bd2e0781d0e3e2e5ad5b6423340209
https://pubmed.ncbi.nlm.nih.gov/25575954
https://pubmed.ncbi.nlm.nih.gov/25575954
Autor:
Hu Ye, Tim Kazules, Ji Ma, Dianna Lester-Zeiner, Essa Hu, Santosh Talreja, Carl Davis, Charlie Glaus, Oliver R. Thiel, Ning Chen, Geraldine Hill Della Puppa, James J. S. Treanor, Shannon Rumfelt, Hui Hannah Dou, Roxanne Kunz, David C. Immke, Jessica Able, Jennifer R. Allen, Silke Miller, Xiaoning Zhao, Hang Chen, Jianxia Shi, Jamie Wong, Toni Williamson, Christopher Biorn, Amy Porter, Klaus Michelsen, Ada Chen
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 352(2)
Phosphodiesterase 10A (PDE10A) inhibitors have therapeutic potential for the treatment of psychiatric and neurologic disorders, such as schizophrenia and Huntington's disease. One of the key requirements for successful central nervous system drug dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2114c0263395e74897b10174822cf2a
https://pubmed.ncbi.nlm.nih.gov/25502803
https://pubmed.ncbi.nlm.nih.gov/25502803