Elevated levels of damage-associated molecular patterns HMGB1 and S100A8/A9 coupled with toll-like receptor-triggered monocyte activation are associated with inflammation in patients with myelofibrosis

Autor: Geraldine De Luca, Nora P. Goette, Paola R. Lev, Maria C. Baroni Pietto, Cecilia P. Marin Oyarzún, Miguel A. Castro Ríos, Beatriz Moiraghi, Federico Sackmann, Laureano J. Kamiya, Veronica Verri, Victoria Caula, Vanina Fernandez, Angeles Vicente, Julio Pose Cabarcos, Vanesa Caruso, Maria F. Camacho, Irene B. Larripa, Marina Khoury, Rosana F. Marta, Ana C. Glembotsky, Paula G. Heller

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

Inflammation plays a pivotal role in the pathogenesis of primary and post-essential thrombocythemia or post-polycythemia vera myelofibrosis (MF) in close cooperation with the underlying molecular drivers. This inflammatory state is induced by a dynam

Externí odkaz: https://doaj.org/article/5df717c398dd4954b8dd7bab8a1b84c2

First description of revertant mosaicism in familial platelet disorder with predisposition to acute myelogenous leukemia: correlation with the clinical phenotype

Autor: Ana C. Glembotsky, Cecilia P. Marin Oyarzún, Geraldine De Luca, Christophe Marzac, Nathalie Auger, Nora P. Goette, Rosana F. Marta, Hana Raslova, Paula G. Heller

Publikováno v: Haematologica, Vol 105, Iss 10 (2020)

Externí odkaz: https://doaj.org/article/a61daa6f8d7444bebdd2a4aca751d131

A Deep Dive into the Pathology of Gray Platelet Syndrome: New Insights on Immune Dysregulation

Autor: Paula G. Heller, Ana C. Glembotsky, Geraldine De Luca

Publikováno v: Journal of Blood Medicine

The gray platelet syndrome (GPS) is a rare platelet disorder, characterized by impaired alpha-granule biogenesis in megakaryocytes and platelets due to NBEAL2 mutations. Typical clinical features include macrothrombocytopenia, bleeding and elevated v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b62b437182f9581fc07a157f3ffe51d9
https://pubmed.ncbi.nlm.nih.gov/34408521

Platelet Toll-Like Receptors Mediate Thromboinflammatory Responses in Patients With Essential Thrombocythemia

Autor: Angeles Vicente, Maria Constanza Baroni Pietto, Rosana F. Marta, Paula G. Heller, Nora Paula Goette, Miguel Castro Rios, Mirta Schattner, Geraldine De Luca, Paola Roxana Lev, Ana C. Glembotsky, Beatriz Moiraghi, Cecilia Paola Marin Oyarzún

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Frontiers in Immunology
Frontiers in Immunology, Vol 11 (2020)

Essential thrombocythemia (ET) is comprised among chronic myeloproliferative neoplasms (MPN) and is caused by driver mutations in JAK2, CALR and MPL, which lead to megakaryocyte proliferation and prominent thrombocytosis. Thrombosis remains the main

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e8c4ca0cf28fca00c1f9757b1c83c87
https://doi.org/10.3389/fimmu.2020.00705

The XY Body of the Cat (Felis catus): Structural Differentiations and Protein Immunolocalization

Autor: Roberta B, Sciurano, Geraldine, De Luca, I Mónica, Rahn, Alberto J, Solari

Publikováno v: Cytogenetic and genome research. 152(3)

The heteromorphic X and Y chromosomes behave in a special way in mammalian spermatocytes; they form the XY body and synapse only partially. The aim of this article was to study the origin and the role of the special differentiations in the XY pair of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1a787770d0e41e7581b81e5336579e75
https://pubmed.ncbi.nlm.nih.gov/28848076