Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Geraldene Rong-Hui Koh"'
Autor:
Beng Ti Ang, Carol Tang, Ivan Ng, Wai Hoe Ng, Greg Tucker-Kellogg, Oi Lian Kon, Siew Hong Leong, Swee Seong Wong, Mark Phong, Edwin Sandanaraj, Geraldene Rong-Hui Koh, Esther Hui-Ling Ting, Tan Boon Toh, Felicia Soo-Lee Ng
PDF file - 688K, Supplementary Fig. S1. NNI-8 GPCs display stemness expression and extensive self-renewal.Supplementary Fig. S2. NNI-8 orthotopic xenograft recapitulates patient tumor pathophysiology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::703b30891d9d2694cbe9d4c67ee4df2d
https://doi.org/10.1158/1078-0432.22443275.v1
https://doi.org/10.1158/1078-0432.22443275.v1
Autor:
Beng Ti Ang, Carol Tang, Ivan Ng, Wai Hoe Ng, Greg Tucker-Kellogg, Oi Lian Kon, Siew Hong Leong, Swee Seong Wong, Mark Phong, Edwin Sandanaraj, Geraldene Rong-Hui Koh, Esther Hui-Ling Ting, Tan Boon Toh, Felicia Soo-Lee Ng
Purpose: Patient-derived glioma-propagating cells (GPC) contain karyotypic and gene expression profiles that are found in the primary tumor. However, their clinical relevance is unclear. We ask whether GPCs contribute to disease progression and survi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a37b35ff8e93d27a56a4853cc92c65ad
https://doi.org/10.1158/1078-0432.c.6519749
https://doi.org/10.1158/1078-0432.c.6519749
Autor:
Yuk Kien Chong, Ivan Ng, Edwin Sandanaraj, Marie-Veronique Clement, Geraldene Rong-Hui Koh, Beng Ti Ang, Wai Hoe Ng, Shazib Pervaiz, Oi Lian Kon, Lynnette Koh, Greg Tucker-Kellogg, Tan Boon Toh, Carol Tang, Felicia Soo Lee Ng, Mark Phong
Publikováno v:
Antioxidants & Redox Signaling. 19:2261-2279
We explore the role of an elevated O2(-):H2O2 ratio as a prosurvival signal in glioma-propagating cells (GPCs). We hypothesize that depleting this ratio sensitizes GPCs to apoptotic triggers.We observed that an elevated O2(-):H2O2 ratio conferred enh
Autor:
Siew Hong Leong, Mark Phong, Felicia Soo Lee Ng, Ivan Ng, Swee Seong Wong, Carol Tang, Oi Lian Kon, Esther Hui-Ling Ting, Edwin Sandanaraj, Tan Boon Toh, Beng Ti Ang, Geraldene Rong-Hui Koh, Wai Hoe Ng, Greg Tucker-Kellogg
Publikováno v:
Clinical Cancer Research. 18:4122-4135
Purpose: Patient-derived glioma-propagating cells (GPC) contain karyotypic and gene expression profiles that are found in the primary tumor. However, their clinical relevance is unclear. We ask whether GPCs contribute to disease progression and survi
Autor:
Joanna D. Holbrook, Chou Chai, Yuk Kien Chong, Beng Ti Ang, Charlene S.F. Foong, Ryosuke Takahashi, Carol Tang, Jeanne M.M. Tan, Lynnette Koh, Edwin Sandanaraj, Geraldene Rong-Hui Koh, Calvin W.S. Yeo, Felicia Soo Lee Ng, Kah-Leong Lim
Publikováno v:
Cancer Research. 72:2543-2553
Mutations in the parkin gene, which encodes a ubiquitin ligase, are a major genetic cause of parkinsonism. Interestingly, parkin also plays a role in cancer as a putative tumor suppressor, and the gene is frequently targeted by deletion and inactivat
Autor:
Yuk Kien Chong, Edwin Sandanaraj, Carol Tang, Kah-Leong Lim, Nguan Soon Tan, Joanna D. Holbrook, Ivan Ng, Moogaambikai Thangaveloo, Geraldene Rong-Hui Koh, Lynnette Koh, Melanie S. Y. Tan, Grace Lim, Tan Boon Toh, Wai Hoe Ng, Oi Lian Kon, Mahendran Nadarajah, Beng Ti Ang
Publikováno v:
JNCI Journal of the National Cancer Institute
Background: Cell surface sialylation is associated with tumor cell invasiveness in many cancers. Glioblastoma is the most malignant primary brain tumor and is highly infiltrative. ST3GAL1 sialyltransferase gene is amplified in a subclass of glioblast
Autor:
Oi Lian Kon, Beng Ti Ang, Joanna D. Holbrook, Yuk Kien Chong, Grace Gy Lim, Ivan Ng, Moogaambikai Thangaveloo, Mahendran Nadarajah, Nguan Soon Tan, Edwin Sandanaraj, Kah-Leong Lim, Melanie Sy Tan, Geraldene Rong-Hui Koh, Wai Hoe Ng, Carol Tang, Tan Boon Toh, Lynnette Koh
Publikováno v:
Cancer Research. 76:4470-4470
Cell surface sialylation has been associated with tumor cell invasiveness in several cancers. Patients with grade IV glioblastoma multiforme (GBM) often show a median survival period of fifteen months, even with the current standard-of-care treatment