Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Geraldene Munsamy"'
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 16, Iss , Pp 573-586 (2018)
Over the years, numerous synthetic approaches have been utilized in drug design to improve the pharmacological properties of naturally derived compounds and most importantly, minimize toxic effects associated with their transition to drugs. The reduc
Externí odkaz:
https://doaj.org/article/fc1b553e8af24dafbbf55107812f0657
Publikováno v:
Chemistry & Biodiversity. 16
The quest for reliable dihydroorotate dehydrogenase (DHODH) inhibitors has engendered the discovery of potential therapeutic compounds at different stages of clinical trials. Although promising, high attrition rates and unfavorable bioactivities have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b90a78cf18fbc7ef28111e6780f369e
https://doi.org/10.1002/cbdv.201900365
https://doi.org/10.1002/cbdv.201900365
Publikováno v:
The protein journal. 38(6)
The invasive tactics employed by the malarial parasite renders malaria a global health threat, further impeding the effective treatment of the mosquito borne-parasitic disease. Although there have been countless efforts directed towards the developme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0248952e02678d3ab1f998969f9119e1
https://pubmed.ncbi.nlm.nih.gov/31586296
https://pubmed.ncbi.nlm.nih.gov/31586296
Publikováno v:
Chemistrybiodiversity. 16(12)
The quest for reliable dihydroorotate dehydrogenase (DHODH) inhibitors has engendered the discovery of potential therapeutic compounds at different stages of clinical trials. Although promising, high attrition rates and unfavorable bioactivities have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9bd6f8c79113d38d23905034d32c39b4
https://pubmed.ncbi.nlm.nih.gov/31589372
https://pubmed.ncbi.nlm.nih.gov/31589372
Publikováno v:
Current pharmaceutical biotechnology. 21(13)
Background: The last few decades have witnessed groundbreaking research geared towards immune surveillance mechanisms and have yielded significant improvements in the field of cancer immunotherapy. This approach narrows down on the development of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd871c67fce9dfa8b2ac6d070a244740
https://pubmed.ncbi.nlm.nih.gov/31738132
https://pubmed.ncbi.nlm.nih.gov/31738132
Publikováno v:
Journal of cellular biochemistry.
Plasmepsin IX and X, members of the prominent aspartic family of proteases whose function were hitherto unknown have only recently been established as key mediators of erythrocyte invasion and egress of the virulent malarial parasite. Inhibitor 49c,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bad23997639eb6bf0a3075444f1727a2
https://pubmed.ncbi.nlm.nih.gov/30430636
https://pubmed.ncbi.nlm.nih.gov/30430636
Publikováno v:
Letters in Drug Design & Discovery. 14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b90bd88dd9e0653b06f445f826c21e1b
https://doi.org/10.2174/1570180814666170110122027
https://doi.org/10.2174/1570180814666170110122027