Zobrazeno 1 - 10 of 30 pro vyhledávání: '"Gerald Wolberg"'
1
Iron chelates bind nitric oxide and decrease mortality in an experimental model of septic shock
Autor: Darryl S. Williams, Wieslaw M. Kazmierski, Luis Molina, H. Holden Thorp, Gerald Wolberg, Joan G. Wilson, Sheila R. Smith
The hydroxamic acid siderophore ferrioxamine B [FeIII(HDFB)+] and the iron complex of diethylenetri-aminepentaacetic acid [FeIII(DTPA)2-] protected mice against death by septic shock induced by Corynebacterium parvum + lipopolysaccharide. Although Fe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32830f5e8b823d7f56e27c88711e3b45
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3
Modulation of cyclic AMP metabolism by S-adenosylhomocysteine and S-3-deazaadenosylhomocysteine in mouse lymphocytes
Autor: Claus J. Schmitges, Robert D. Deeprose, Gail S. Duncan, Thomas P. Zimmerman, Gertrude B. Elion, Gerald Wolberg, Pedro Cuatrecasas
Publikováno v: Proceedings of the National Academy of Sciences. 77:5639-5643
Mouse lymphocytes incubated with micromolar concentrations of adenosine or 3-deazaadenosine, in medium supplemented with L-homocysteine, rapidly accumulated supramillimolar concentrations of S-adenosylhomocysteine (AdoHcy) or S-3-deazaadenosylhomocys
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bea742a6f9e8ec929d026f4b3e8e1934
https://doi.org/10.1073/pnas.77.10.5639
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4
Inhibition of lymphocyte-mediated cytolysis by 3-deazaadenosine: Evidence for a methylation reaction essential to cytolysis
Autor: Gail S. Duncan, Gerald Wolberg, Thomas P. Zimmerman
Publikováno v: Proceedings of the National Academy of Sciences. 75:6220-6224
3-Deazaadenosine (deazaAdo) inhibits lymphocyte-mediated cytolysis in vitro at micromolar concentrations and is potentiated markedly in this activity by L-homocysteine thiolactone. DeazaAdo alone causes a rapid, dose-dependent buildup of S-[ 3 H]aden
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80ee8e34af744be10528167754b5fd83
https://doi.org/10.1073/pnas.75.12.6220
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6
3-Deazaadenosine. S-adenosylhomocysteine hydrolase-independent mechanism of action in mouse lymphocytes
Autor: Thomas P. Zimmerman, Marie A. Iannone, Gerald Wolberg
Publikováno v: Journal of Biological Chemistry. 259:1122-1126
3-Deazaadenosine (c3Ado) inhibits the ability of specifically sensitized mouse lymphocytes to lyse tumor cells, and this effect of c3Ado on immune function is accompanied by a buildup of both S-adenosylhomocysteine (AdoHcy) and S-3-deazaadenosylhomoc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8de0a8767ac6f29da033c54ac4f17615
https://doi.org/10.1016/s0021-9258(17)43575-7
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7
Effects of adenosine on neutrophil polarization induced by N-formyl-methionyl-leucyl-phenylalanine, sodium propionate and colchicine
Autor: Gerald Wolberg, Marie A. Iannone
Publikováno v: Agents and Actions. 27:403-406
Polarization of human neutrophils (a characteristic bipolar shape change) can be induced by the chemotactic peptide N-formyl-methionyl-leucyl-phenylalanine (FMLP); sodium propionate, which causes a rapid acidification of the cytosol; or colchicine, w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adeb4fd42896dad99a2c89eabe7f7b55
https://doi.org/10.1007/bf01972835
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8
Immunosuppressive Effects of the S-Adenosylhomocysteine Hydrolase Inhibitor, 3-Deazaadenosine
Autor: Joseph L. Medzihradsky, Gertrude B. Elion, Gerald Wolberg, Thomas P. Zimmerman
Publikováno v: Journal of Immunopharmacology. 4:29-41
Immunosuppressive effects of 3-deazaadenosine (3-DAA), an inhibitor of S-adenosylhomocysteine hydrolase, were tested in vivo in immune assays against sheep red blood cells (SRBC), involving serum titrations for hemagglutinins and hemolysins, cellular
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ebe843fb825106e9124fd3441505f06
https://doi.org/10.3109/08923978209031073
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9
Potentiation by homocysteine of adenosine-stimulated elevation of cellular adenosine 3′,5′-monophosphate
Autor: Thomas P. Zimmerman, Gail S. Duncan, Robert D. Deeprose, Gerald Wolberg
Publikováno v: Biochemical Pharmacology. 28:2375-2379
The novel ability of l -homocysteine (Hcy) to potentiate the cellular elevation of adenosine 3′,5′-monophosphate (cAMP) caused by adenosine (Ado) is described. This effect of Hcy is highly selective in that it is not mimicked by l -cysteine, and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc87d2a6b401a049450da20b6f82d376
https://doi.org/10.1016/0006-2952(79)90703-2
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10
Inhibition of lymphocyte-mediated cytolysis by 2-fluoroadenosine
Autor: Gerald Wolberg, Gertrude B. Elion, Thomas A. Krenitsky, Lowrie M. Beacham, Janet L. Rideout, Gail S. Duncan, Thomas P. Zimmerman
Publikováno v: Biochemical Pharmacology. 27:1731-1737
2-Fluoroadenosine (F-Ado) is a potent, irreversible inhibitor of lymphocyte-mediated cytolysis (LMC) in vitro: the irreversibility of this inhibition has been attributed to the metabolism of F-Ado to 2-fluoroadenosine t′-triphosphate (F-ATP) and 2-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::954f0510429134dbe9fbd56c806adcb3
https://doi.org/10.1016/0006-2952(78)90549-x
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