Zobrazeno 1 - 10
of 457
pro vyhledávání: '"Gerald W. Zamponi"'
Autor:
Ivana A. Souza, Maria A. Gandini, Md Yousof Ali, Franz Kricek, George Skouteris, Gerald W. Zamponi
Publikováno v:
Molecular Brain, Vol 17, Iss 1, Pp 1-5 (2024)
Abstract NVA1309 is a non-brain penetrant next-generation gabapentinoid shown to bind Cavα2δ at R243 within a triple Arginine motif forming the binding site for gabapentin and pregabalin. In this study we have compared the effects of NVA1309 with M
Externí odkaz:
https://doaj.org/article/749b5859556c4aec98802cff2b822159
Autor:
Charlie H. T. Kwok, Erika K. Harding, Nicole E. Burma, Tamara Markovic, Nicolas Massaly, Nynke J. van den Hoogen, Sierra Stokes-Heck, Eder Gambeta, Kristina Komarek, Hye Jean Yoon, Kathleen E. Navis, Brendan B. McAllister, Julia Canet-Pons, Churmy Fan, Rebecca Dalgarno, Evgueni Gorobets, James W. Papatzimas, Zizhen Zhang, Yuta Kohro, Connor L. Anderson, Roger J. Thompson, Darren J. Derksen, Jose A. Morón, Gerald W. Zamponi, Tuan Trang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Opioid withdrawal is a liability of chronic opioid use and misuse, impacting people who use prescription or illicit opioids. Hyperactive autonomic output underlies many of the aversive withdrawal symptoms that make it difficult to discontinu
Externí odkaz:
https://doaj.org/article/d65c6d8ddef244efbd66f10b378d8cc2
Publikováno v:
Molecular Brain, Vol 17, Iss 1, Pp 1-9 (2024)
Abstract The ventrolateral periaqueductal gray (vlPAG) serves as a central hub for descending pain modulation. It receives upstream projections from the medial prefrontal cortex (mPFC) and the ventrolateral orbitofrontal cortex (vlOFC), and projects
Externí odkaz:
https://doaj.org/article/51f231119dd04dc2aa70131f7f71da07
Autor:
Erika K. Harding, Zizhen Zhang, Julia Canet-Pons, Sierra Stokes-Heck, Tuan Trang, Gerald W. Zamponi
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109972- (2024)
Summary: The ventrolateral periaqueductal gray (vlPAG) functionally projects to diverse brain regions, including the locus coeruleus (LC). Excitatory projections from the vlPAG to the LC are well described, while few studies have indicated the possib
Externí odkaz:
https://doaj.org/article/34c3a51d2ab94763beb36392c4c4545c
Autor:
Laurent Ferron, Erika K. Harding, Maria A. Gandini, Craig Brideau, Peter K. Stys, Gerald W. Zamponi
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109973- (2024)
Summary: N- and P/Q-type voltage-gated Ca2+ channels are critical for synaptic transmission. While their expression is increased in the dorsal root ganglion (DRG) neuron cell bodies during neuropathic pain conditions, less is known about their synapt
Externí odkaz:
https://doaj.org/article/f7dd9b2885184647aa707d0d4f9e7033
Autor:
Franz Kricek, Christine Ruf, Premji Meghani, Ivana A. Souza, Maria A. Gandini, Gerald W. Zamponi, George Skouteris
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 174, Iss , Pp 116472- (2024)
The Voltage-Gated Calcium Channel (VGCC) auxiliary subunit Cavα2δ-1 (CACNA2D1) is the target/receptor of gabapentinoids which are known therapeutics in epilepsy and neuropathic pain. Following damage to the peripheral sensory nervous system, Cavα2
Externí odkaz:
https://doaj.org/article/a907b72b95b0430185c1465eca18b428
Publikováno v:
Molecular Brain, Vol 16, Iss 1, Pp 1-5 (2023)
Abstract T-type calcium channelopathies encompass a group of human disorders either caused or exacerbated by mutations in the genes encoding different T-type calcium channels. Recently, a new heterozygous missense mutation in the CACNA1H gene that en
Externí odkaz:
https://doaj.org/article/f558935862cf41128a425c662d031105
Autor:
Heloísa Alonso-Matielo, Zizhen Zhang, Eder Gambeta, Junting Huang, Lina Chen, Gabriel Oliveira de Melo, Camila Squarzoni Dale, Gerald W. Zamponi
Publikováno v:
Molecular Brain, Vol 16, Iss 1, Pp 1-5 (2023)
Abstract The insula and anterior cingulate cortex (ACC) are brain regions that undergo structural and functional reorganization in neuropathic pain states. Here, we aimed to study inhibitory parvalbumin positive (PV+) posterior insula (pIC) to poster
Externí odkaz:
https://doaj.org/article/5a4288109786492782bfb6db69a25f8d
Autor:
Daniel F. Martins, Victor Sorrentino, Leidiane Mazzardo-Martins, William R. Reed, Adair R. S. Santos, Vinícius M. Gadotti, Gerald W. Zamponi
Publikováno v:
Molecular Brain, Vol 16, Iss 1, Pp 1-4 (2023)
Abstract The present study was undertaken to explore the relative contributions of Cav3.2 T-type channels to mediating the antihyperalgesic activity of joint manipulation (JM) therapy. We used the chronic constriction injury model (CCI) to induce per
Externí odkaz:
https://doaj.org/article/d87d0148067549d8872637980e3640bc
Publikováno v:
Molecular Brain, Vol 16, Iss 1, Pp 1-4 (2023)
Abstract Delta-9-tetrahydrocannabinol (Δ9-THC) is known to produce systemic analgesia that involves CB1 and CB2 cannabinoid receptors. However, there is compelling evidence that Δ9-THC can potently inhibit Cav3.2T-type calcium channels which are hi
Externí odkaz:
https://doaj.org/article/00259e3533e64537955ae7eae5d123c0