Zobrazeno 1 - 10
of 431
pro vyhledávání: '"Gerald W. HART"'
Norepinephrine transporter defects lead to sympathetic hyperactivity in Familial Dysautonomia models
Autor:
Hsueh-Fu Wu, Wenxin Yu, Kenyi Saito-Diaz, Chia-Wei Huang, Joseph Carey, Frances Lefcort, Gerald W. Hart, Hong-Xiang Liu, Nadja Zeltner
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Sympathetic neurons are affected in familial dysautonomia, a rare disease associated with a mutation in ELP1, but the mechanisms are not fully understood. Here the authors show, using neurons derived from participants with familial dysauotnomia, that
Externí odkaz:
https://doaj.org/article/0aa61b6874b840a68056479fc501db76
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
O-GlcNAcylation is a post-translational modification (PTM) that regulates a wide range of cellular functions and has been associated with multiple metabolic diseases in various organs. The sympathetic nervous system (SNS) is the efferent portion of t
Externí odkaz:
https://doaj.org/article/d0edf94f88504e9db6a15704a368b4d2
Autor:
Jie L. Tian, Chia-Wei Huang, Farzad Eslami, Michael Philip Mannino, Rebecca Lee Mai, Gerald W. Hart
Publikováno v:
Cells, Vol 12, Iss 11, p 1520 (2023)
The primary cilium plays critical roles in the homeostasis and development of neurons. Recent studies demonstrate that cilium length is regulated by the metabolic state of cells, as dictated by processes such as glucose flux and O-GlcNAcylation (OGN)
Externí odkaz:
https://doaj.org/article/a8efe644c06e4b95aa0425c17d17da86
Autor:
Michael P. Mannino, Gerald W. Hart
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The addition of N-acetyl glucosamine (GlcNAc) on the hydroxy group of serine/threonine residues is known as O-GlcNAcylation (OGN). The dynamic cycling of this monosaccharide on and off substrates occurs via O-linked β-N-acetylglucosamine transferase
Externí odkaz:
https://doaj.org/article/10668495af1f4e4883fa118d16d0f4de
Autor:
Jie L. Tian, Chia-Wei Huang, Farzad Eslami, Michael Philip Mannino, Rebecca Lee Mai, Gerald W. Hart
The primary cilium plays critical roles in homeostasis and development of neurons. Recent studies demonstrate that cilia length is regulated by the metabolic state of cells, as dictated by processes such as glucose flux and O-GlcNAcylation (OGN). The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7df8a7b6947c4c21ce9d4ba2216a16d1
https://doi.org/10.20944/preprints202304.0345.v1
https://doi.org/10.20944/preprints202304.0345.v1
Autor:
Chia‐Wei Huang, Nicholas C. Rust, Hsueh‐Fu Wu, Amelia Yin, Nadja Zeltner, Hang Yin, Gerald W. Hart
Publikováno v:
Alzheimer's & Dementia.
Publikováno v:
Encyclopedia of Cell Biology ISBN: 9780128216248
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63aeeb408f41d3f6fadaa31f4372c29f
https://doi.org/10.1016/b978-0-12-821618-7.09005-2
https://doi.org/10.1016/b978-0-12-821618-7.09005-2
Autor:
Gerald W. Hart
Publikováno v:
Encyclopedia of Cell Biology ISBN: 9780128216248
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e958447b26abb3ceeaa353e6a407a87e
https://doi.org/10.1016/b978-0-12-821618-7.00233-9
https://doi.org/10.1016/b978-0-12-821618-7.00233-9
Autor:
Partha S. Banerjee, Oscar E. Reyes Gaido, C. Conover Talbot, Neha Abrol, Elizabeth D. Luczak, Gerald W. Hart, Liliana Florea, Jonathan M. Granger, Natasha E. Zachara, Qinchuan Wang, Olurotimi O. Mesubi, An-Chi Wei, Mark E. Anderson, Priya Umapathi, Yuejin Wu
Publikováno v:
Circulation. 143:1687-1703
Background: Heart failure is a leading cause of death worldwide and is associated with the rising prevalence of obesity, hypertension, and diabetes. O -GlcNAcylation (the attachment of O -linked β-N-acetylglucosamine [ O -GlcNAc] moieties to cytopla
Autor:
Yi Zhu, Gerald W. Hart
Publikováno v:
Cell. 186:428-445.e27