Zobrazeno 1 - 10
of 22 214
pro vyhledávání: '"Gerald W"'
Autor:
Sweta Ghosh, Rajbir Singh, Tanu Jain Goap, Omprakash Sunnapu, Zachary M. Vanwinkle, Hong Li, Syam P. Nukavarapu, Gerald W. Dryden, Bodduluri Haribabu, Praveen Kumar Vemula, Venkatakrishna Rao Jala
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-20 (2024)
Abstract Inflammatory bowel disease (IBD) treatment often involves systemic administration of anti-inflammatory drugs or biologics such as anti-TNF-α antibodies. However, current drug therapies suffer from limited efficacy due to unresponsiveness an
Externí odkaz:
https://doaj.org/article/c20555755e4b4f14b26bde958ff2edad
Autor:
Jetty A. M. Weijers, Gerald W. Verhaegh, G. Lassche, Adriana C. H. van Engen-van Grunsven, Chantal M. L. Driessen, Nielka P. van Erp, Marianne A. Jonker, Jack A. Schalken, Carla M. L. van Herpen
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-10 (2024)
Abstract Background Salivary duct carcinoma (SDC) is a rare and aggressive subtype of salivary gland cancer, frequently associated with incurable recurrences and distant metastases (R/M). Proliferation of SDC relies on androgen receptor (AR) signalli
Externí odkaz:
https://doaj.org/article/a5bc0409b05e44f287a00260be8d6cfe
Autor:
Ivana A. Souza, Maria A. Gandini, Md Yousof Ali, Franz Kricek, George Skouteris, Gerald W. Zamponi
Publikováno v:
Molecular Brain, Vol 17, Iss 1, Pp 1-5 (2024)
Abstract NVA1309 is a non-brain penetrant next-generation gabapentinoid shown to bind Cavα2δ at R243 within a triple Arginine motif forming the binding site for gabapentin and pregabalin. In this study we have compared the effects of NVA1309 with M
Externí odkaz:
https://doaj.org/article/749b5859556c4aec98802cff2b822159
Autor:
Charlie H. T. Kwok, Erika K. Harding, Nicole E. Burma, Tamara Markovic, Nicolas Massaly, Nynke J. van den Hoogen, Sierra Stokes-Heck, Eder Gambeta, Kristina Komarek, Hye Jean Yoon, Kathleen E. Navis, Brendan B. McAllister, Julia Canet-Pons, Churmy Fan, Rebecca Dalgarno, Evgueni Gorobets, James W. Papatzimas, Zizhen Zhang, Yuta Kohro, Connor L. Anderson, Roger J. Thompson, Darren J. Derksen, Jose A. Morón, Gerald W. Zamponi, Tuan Trang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Opioid withdrawal is a liability of chronic opioid use and misuse, impacting people who use prescription or illicit opioids. Hyperactive autonomic output underlies many of the aversive withdrawal symptoms that make it difficult to discontinu
Externí odkaz:
https://doaj.org/article/d65c6d8ddef244efbd66f10b378d8cc2
Publikováno v:
Molecular Brain, Vol 17, Iss 1, Pp 1-9 (2024)
Abstract The ventrolateral periaqueductal gray (vlPAG) serves as a central hub for descending pain modulation. It receives upstream projections from the medial prefrontal cortex (mPFC) and the ventrolateral orbitofrontal cortex (vlOFC), and projects
Externí odkaz:
https://doaj.org/article/51f231119dd04dc2aa70131f7f71da07
Autor:
Hassan Gamal, Khadiga A. Ismail, A-Mohsen M. E. Omar, Mohamed Teleb, Marwa M. Abu-Serie, Sun Huang, Abdalla S. Abdelsattar, Gerald W. Zamponi, Hesham Fahmy
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
Cisplatin remains the unchallenged standard therapy for NSCLC. However, it is not completely curative due to drug resistance and oxidative stress-induced toxicity. Drug resistance is linked to overexpression of matrix metalloproteinases (MMPs) and ab
Externí odkaz:
https://doaj.org/article/5539ecc082aa403a859e84b2104d936f
Autor:
Gerald W. Tannock
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
Human gut microbiomes (microbiotas) are highly individualistic in taxonomic composition but nevertheless are functionally similar. Thus, collectively, they comprise a “metacommunity.” In ecological terminology, the assembly of human gut microbiom
Externí odkaz:
https://doaj.org/article/8413b31560f540f29374a9524aa7bf16
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/f8fde46f69d54d43b3121cb5a58fa43d
Correction: Cisplatin resistance can be curtailed by blunting Bnip3-mediated mitochondrial autophagy
Autor:
Caterina Vianello, Veronica Cocetta, Daniela Catanzaro, Gerald W Dorn, Angelo De Milito, Flavio Rizzolio, Vincenzo Canzonieri, Erika Cecchin, Rossana Roncato, Giuseppe Toffoli, Vincenzo Quagliariello, Annabella Di Mauro, Simona Losito, Nicola Maurea, Cono Scaffa, Gabriele Sales, Luca Scorrano, Marta Giacomello, Monica Montopoli
Publikováno v:
Cell Death and Disease, Vol 15, Iss 1, Pp 1-5 (2024)
Externí odkaz:
https://doaj.org/article/114595f88d4f4060b2e43743b250d29d
Autor:
Erika K. Harding, Zizhen Zhang, Julia Canet-Pons, Sierra Stokes-Heck, Tuan Trang, Gerald W. Zamponi
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109972- (2024)
Summary: The ventrolateral periaqueductal gray (vlPAG) functionally projects to diverse brain regions, including the locus coeruleus (LC). Excitatory projections from the vlPAG to the LC are well described, while few studies have indicated the possib
Externí odkaz:
https://doaj.org/article/34c3a51d2ab94763beb36392c4c4545c