Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Gerald Schwerdt"'
Autor:
Virginie Dubourg, Gerald Schwerdt, Barbara Schreier, Michael Kopf, Sigrid Mildenberger, Ralf A. Benndorf, Michael Gekle
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Endothelial cells (EC) are key players in vascular function, homeostasis and inflammation. EC show substantial heterogeneity due to inter-individual variability (e.g. sex-differences) and intra-individual differences as they originate from d
Externí odkaz:
https://doaj.org/article/d85fe54df585415eadc3aa04dfbb82dd
Autor:
Marie-Christin Schulz, Virginie Dubourg, Alexander Nolze, Michael Kopf, Gerald Schwerdt, Michael Gekle
Publikováno v:
Antioxidants, Vol 12, Iss 2, p 412 (2023)
Crosstalk of renal epithelial cells with interstitial fibroblasts plays an important role in kidney pathophysiology. A previous study showed that crosstalk between renal epithelial cells and renal fibroblasts protects against acidosis-induced damage.
Externí odkaz:
https://doaj.org/article/4404032215334d618415a9bd78a7e602
Autor:
Virginie Dubourg, Barbara Schreier, Gerald Schwerdt, Sindy Rabe, Ralf A. Benndorf, Michael Gekle
Publikováno v:
Cells, Vol 11, Iss 12, p 1936 (2022)
In vivo, cells are simultaneously exposed to multiple stimuli whose effects are difficult to distinguish. Therefore, they are often investigated in experimental cell culture conditions where stimuli are applied separately. However, it cannot be presu
Externí odkaz:
https://doaj.org/article/4edd169391d546f584bf698c7b4e6648
Publikováno v:
Biomedicines, Vol 10, Iss 3, p 681 (2022)
Pathogenesis of chronic kidney disease (CKD) is accompanied by extracellular acidosis inflammation, fibrosis and epithelial-to-mesenchymal transition (EMT). The aim of this study was to assess the influence of acidosis on tubule epithelial cells (NRK
Externí odkaz:
https://doaj.org/article/4c54cee209ec4cb790561ee17315f9c9
Publikováno v:
Toxins, Vol 13, Iss 3, p 219 (2021)
The kidney is threatened by a lot of potentially toxic substances. To study the influence of the nephrotoxin ochratoxin A (OTA) we established a cell co-culture model consisting of human renal proximal tubule cells and fibroblasts. We studied the eff
Externí odkaz:
https://doaj.org/article/56eda8642bdb419182551f8956b797d9
Publikováno v:
Cells, Vol 9, Iss 1, p 143 (2020)
Environmental food contaminants constitute a threat to human health. For instance, the globally spread mycotoxin Ochratoxin A (OTA) contributes to chronic kidney damage by affecting proximal tubule cells via unknown mechanisms. We applied a top-down
Externí odkaz:
https://doaj.org/article/4991c4cf9558471887dc33b64ed6d3d0
Autor:
Andreas Benesic, Gerald Schwerdt, Isabell Hennemeier, Christoph Sauvant, Sigrid Mildenberger, Michael Gekle
Publikováno v:
Cellular Physiology and Biochemistry, Vol 33, Iss 4, Pp 1106-1116 (2014)
Background/Aims: Chronic renal proximal tubule dysfunction after therapy with the antineoplastic agent ifosfamide (IFO) is often attributed to the metabolite chloroacetaldehyde (CAA). Chronic IFO-nephropathy is reported to result in tubulointerstitia
Externí odkaz:
https://doaj.org/article/55684ea6c0bd4cd0bcbef156d82431e8
Publikováno v:
Toxins
Volume 13
Issue 3
Toxins, Vol 13, Iss 219, p 219 (2021)
Volume 13
Issue 3
Toxins, Vol 13, Iss 219, p 219 (2021)
The kidney is threatened by a lot of potentially toxic substances. To study the influence of the nephrotoxin ochratoxin A (OTA) we established a cell co-culture model consisting of human renal proximal tubule cells and fibroblasts. We studied the eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03086cb6805d7eb07a7981c356a3f7c6
Autor:
Luise Schumann, Ulrike Rottkord, Hans-Ulrich Humpf, Michael Gekle, Gerald Schwerdt, Marie-Christin Schulz
Publikováno v:
Toxicology Letters. 291:149-157
Increased ochratoxin A (OTA) or citrinin (CIT) concentrations in food correlate with increased prevalence of tubule-interstitial nephropathy. We tested the hypothesis that co-exposure of human proximal tubule-derived epithelial cells (HK-2) to OTA an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c1c157d2a5d0cb70e655289cec14b1e
https://doi.org/10.1016/j.toxlet.2018.04.014
https://doi.org/10.1016/j.toxlet.2018.04.014
Autor:
Paolo Fornara, Barbara Seliger, Marcel Köhn, Isabell Hennemeier, Sandro Dittmar, Patrick Azinovic, Hans-Ulrich Humpf, Mirjana Polovic, Alexander Nolze, Gerald Schwerdt, Michael Gekle, Gerit Theil
Publikováno v:
Cellular and Molecular Life Sciences. 75:2241-2256
Long non-coding RNAs represent a fraction of the transcriptome that is being increasingly recognized. For most of them no function has been allocated so far. Here, we describe the nature and function of a novel non-protein-coding transcript, named WI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b926044c0e74c6166fcaa38893cb3bf0
https://doi.org/10.1007/s00018-017-2731-6
https://doi.org/10.1007/s00018-017-2731-6