Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Gerald Schwerd"'
Publikováno v:
Toxins, Vol 13, Iss 3, p 219 (2021)
The kidney is threatened by a lot of potentially toxic substances. To study the influence of the nephrotoxin ochratoxin A (OTA) we established a cell co-culture model consisting of human renal proximal tubule cells and fibroblasts. We studied the eff
Externí odkaz:
https://doaj.org/article/56eda8642bdb419182551f8956b797d9
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 8, Iss 2, Pp 143-152 (2006)
The expression and activity of P-glycoprotein (pGP) play a role in the multidrug resistance of tumors. Because solid-growing tumors often show pronounced hypoxia or extracellular acidosis, this study attempted to analyze the impact of an acidic envir
Externí odkaz:
https://doaj.org/article/51e497e4120445659aedbfae0bd70747
Autor:
Virginie Dubourg, Gerald Schwerdt, Barbara Schreier, Michael Kopf, Sigrid Mildenberger, Ralf A. Benndorf, Michael Gekle
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Endothelial cells (EC) are key players in vascular function, homeostasis and inflammation. EC show substantial heterogeneity due to inter-individual variability (e.g. sex-differences) and intra-individual differences as they originate from d
Externí odkaz:
https://doaj.org/article/d85fe54df585415eadc3aa04dfbb82dd
Autor:
Marie-Christin Schulz, Virginie Dubourg, Alexander Nolze, Michael Kopf, Gerald Schwerdt, Michael Gekle
Publikováno v:
Antioxidants, Vol 12, Iss 2, p 412 (2023)
Crosstalk of renal epithelial cells with interstitial fibroblasts plays an important role in kidney pathophysiology. A previous study showed that crosstalk between renal epithelial cells and renal fibroblasts protects against acidosis-induced damage.
Externí odkaz:
https://doaj.org/article/4404032215334d618415a9bd78a7e602
Autor:
Virginie Dubourg, Barbara Schreier, Gerald Schwerdt, Sindy Rabe, Ralf A. Benndorf, Michael Gekle
Publikováno v:
Cells, Vol 11, Iss 12, p 1936 (2022)
In vivo, cells are simultaneously exposed to multiple stimuli whose effects are difficult to distinguish. Therefore, they are often investigated in experimental cell culture conditions where stimuli are applied separately. However, it cannot be presu
Externí odkaz:
https://doaj.org/article/4edd169391d546f584bf698c7b4e6648
Publikováno v:
Biomedicines, Vol 10, Iss 3, p 681 (2022)
Pathogenesis of chronic kidney disease (CKD) is accompanied by extracellular acidosis inflammation, fibrosis and epithelial-to-mesenchymal transition (EMT). The aim of this study was to assess the influence of acidosis on tubule epithelial cells (NRK
Externí odkaz:
https://doaj.org/article/4c54cee209ec4cb790561ee17315f9c9
Publikováno v:
Cells, Vol 9, Iss 1, p 143 (2020)
Environmental food contaminants constitute a threat to human health. For instance, the globally spread mycotoxin Ochratoxin A (OTA) contributes to chronic kidney damage by affecting proximal tubule cells via unknown mechanisms. We applied a top-down
Externí odkaz:
https://doaj.org/article/4991c4cf9558471887dc33b64ed6d3d0
Autor:
Andreas Benesic, Gerald Schwerdt, Isabell Hennemeier, Christoph Sauvant, Sigrid Mildenberger, Michael Gekle
Publikováno v:
Cellular Physiology and Biochemistry, Vol 33, Iss 4, Pp 1106-1116 (2014)
Background/Aims: Chronic renal proximal tubule dysfunction after therapy with the antineoplastic agent ifosfamide (IFO) is often attributed to the metabolite chloroacetaldehyde (CAA). Chronic IFO-nephropathy is reported to result in tubulointerstitia
Externí odkaz:
https://doaj.org/article/55684ea6c0bd4cd0bcbef156d82431e8