Zobrazeno 1 - 10 of 32 pro vyhledávání: '"Gerald Saldanha"'
1
Comparison of the prognostic value of microscopically measured invasive width versus macroscopic width in cutaneous melanoma shows the superiority of microscopic invasive width measurement
Autor: Mark Bamford, Louisa Udensi, Arushi Khanna, Marie O'Riordan, Gerald Saldanha
Publikováno v: Journal of Cutaneous Pathology. 49:536-542
Invasive width, the distance between the most peripheral invasive melanoma cells on the section where Breslow thickness (BT) was measured, was recently identified as a prognostic feature. It is unclear whether a routine measurement is justified, give
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::121dcb4026a2a73bc244724c2b1d6909
https://doi.org/10.1111/cup.14220
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3
The Width of Invasion in Malignant Melanoma Is a Novel Prognostic Feature That Accounts for Outcome Better Than Breslow Thickness
Autor: Gerald Saldanha, Mark Bamford, Marie O'Riordan, Aarushi Khanna
Publikováno v: The American journal of surgical pathology. 44(11)
Breslow thickness (BT) is the cornerstone of malignant melanoma staging. However, to our knowledge no-one has ever assessed the horizontal width of invasion, measured microscopically, as a prognostic feature. This was investigated as a prognostic fea
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57f7c28f92e52296b6f844a968391ece
https://pubmed.ncbi.nlm.nih.gov/32604169
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4
DETECTION OF BRAF MUTATION IN MELANOMA FOUND IN TISSUE AND CFDNA BY USING A HIGHLY SENSITIVE PNA-CLAMP PCR
Autor: Gerald Saldanha, Reger R. Mikaeel, Isavella Evangelou, Joshua Bilbie, J.H. Pringle
Publikováno v: The Journal of The University of Duhok. 20:119-141
Malignant melanoma results from ongoing activation of the mitogen activated protein kinases(MAPK ) pathway, commonly driven by mutations in BRAF. Several selective inhibitors of this pathway are used clinically, most notably the Vemurafenib and Dabra
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::249d9ef73e0b3d0f1ea9ce65385fbd2e
https://doi.org/10.26682/sjuod.2018.20.1.12
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5
A Novel Numerical Scoring System for Melanoma Tumor-infiltrating Lymphocytes Has Better Prognostic Value Than Standard Scoring
Autor: Kah Wee Teo, Gerald Saldanha, Mark Bamford, Katarina Flatman
Publikováno v: American Journal of Surgical Pathology. 41:906-914
The purpose of this study was to evaluate the prognostic value of tumor-infiltrating lymphocytes (TILs) in melanoma and to determine whether a simpler numerical scoring system would be more effective. In total, 655 patients presenting to a UK teachin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec98f9d40019b0e670a3a69e5aca9dd0
https://doi.org/10.1097/pas.0000000000000848
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6
A small multimarker panel using simple immunohistochemistry methods is an adjunct to stage for cutaneous melanoma prognosis
Autor: Sam T. Romaine, Gerald Saldanha, J.H. Pringle, Tracey de Haro, Avni Dave-Thakrar, Joanna North, Peter Wells-Jordan
Publikováno v: Melanoma Research. 26:580-587
Melanoma is an aggressive cancer. Outcomes can vary significantly for lesions within the same pathological stage - a problem of increasing relevance with the promise of adjuvant treatments on the basis of immune checkpoint modulators and targeted the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bc48b350a914b2728c7bc552027b413
https://doi.org/10.1097/cmr.0000000000000293
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7
Global and mitosis-specific interobserver variation in mitotic count scoring and implications for malignant melanoma staging
Autor: Alan Evans, Philip D. Da Forno, Gerald Saldanha, Olivia Espinosa de los Monteros, Mark Bamford, Ed Rytina, Lynne Jamieson, Paul Craig, Ahmed Basiouni, Sara Edward, Peter Colloby, Rachael Bishop, Rokiah Ali, Arti Bakshi
Publikováno v: HistopathologyReferences. 76(6)
AIMS Staging is the gold standard for predicting malignant melanoma outcome but changes in its criteria over time indicate ongoing evolution. One notable recent change from the 8th edition of the American Joint Committee on Cancer (AJCC) staging manu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afe9acc698930bf300a84fd3c546caf6
https://pubmed.ncbi.nlm.nih.gov/31879972
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8
Development and Initial Validation of Calculated Tumor Area as a Prognostic Tool in Cutaneous Malignant Melanoma
Autor: Marie O'Riordan, Hussein Uraiby, Gerald Saldanha, Somaia Elsheikh, Mark Bamford, Jeremy Yarrow
Publikováno v: JAMA Dermatol
Importance Breslow thickness is a 1-dimensional surrogate prognostic feature for tumor size, yet tissue sections have 2 dimensions. Therefore, a 2-dimensional feature, calculated tumor area (CTA), was devised. Objective To determine CTA precision and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d0753b08d638b6d53d27aa003778160
https://pubmed.ncbi.nlm.nih.gov/31241720
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10
MicroRNA-21 expression and its pathogenetic significance in cutaneous melanoma
Autor: Gerald Saldanha, Sophie Watson, Linda Potter, J.H. Pringle, Yee Shin Lee, Priya Shendge
Publikováno v: Melanoma Research. 26:21-28
Identification of prognostic biomarkers is timely for melanoma as clinicians seek ways to stratify patients for molecular therapy. MicroRNAs are promising as tissue biomarkers because they can be assayed directly from formalin-fixed paraffin-embedded
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1f7f907473ca7253762222047ff5a00
https://doi.org/10.1097/cmr.0000000000000216
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