Zobrazeno 1 - 10
of 158
pro vyhledávání: '"Gerald S Shadel"'
Autor:
Jeanne F Nichols, Ryan Moran, Howard J Phang, Stephanie R Heimler, Lina M Scandalis, David Wing, Daniel Moreno, Gerald S Shadel, Fred H Gage, Anthony J A Molina
Publikováno v:
BMJ Open, Vol 14, Iss 6 (2024)
Introduction While it is well recognised that aging is a heterogeneous process, our understanding of the determinants of biological aging and its heterogeneity remains unclear. The San Diego Nathan Shock Center (SD-NSC) Clinical Cohort aims to establ
Externí odkaz:
https://doaj.org/article/7d8cd9a0abba4c6285340ff8ff1a52db
Autor:
Lizhen Wu, Jian Cao, Wesley L Cai, Sabine M Lang, John R Horton, Daniel J Jansen, Zongzhi Z Liu, Jocelyn F Chen, Meiling Zhang, Bryan T Mott, Katherine Pohida, Ganesha Rai, Stephen C Kales, Mark J Henderson, Xin Hu, Ajit Jadhav, David J Maloney, Anton Simeonov, Shu Zhu, Akiko Iwasaki, Matthew D Hall, Xiaodong Cheng, Gerald S Shadel, Qin Yan
Publikováno v:
PLoS Biology, Vol 16, Iss 8, p e2006134 (2018)
Cyclic GMP-AMP (cGAMP) synthase (cGAS) stimulator of interferon genes (STING) senses pathogen-derived or abnormal self-DNA in the cytosol and triggers an innate immune defense against microbial infection and cancer. STING agonists induce both innate
Externí odkaz:
https://doaj.org/article/b82bd2d7d5a04000a7a64e580355ce3f
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e20441 (2011)
Synthesis and assembly of the mitochondrial oxidative phosphorylation (OXPHOS) system requires genes located both in the nuclear and mitochondrial genomes, but how gene expression is coordinated between these two compartments is not fully understood.
Externí odkaz:
https://doaj.org/article/6937ff0cc4974e1b8608216b7b6a1a16
Autor:
Sarit Suissa, Zhibo Wang, Jason Poole, Sharine Wittkopp, Jeanette Feder, Timothy E Shutt, Douglas C Wallace, Gerald S Shadel, Dan Mishmar
Publikováno v:
PLoS Genetics, Vol 5, Iss 5, p e1000474 (2009)
Although the functional consequences of mitochondrial DNA (mtDNA) genetic backgrounds (haplotypes, haplogroups) have been demonstrated by both disease association studies and cell culture experiments, it is not clear which of the mutations within the
Externí odkaz:
https://doaj.org/article/1a91ccc462a54c74b4362e6148a5d28e
Autor:
Joe Nassour, Lucia Gutierrez Aguiar, Adriana Correia, Tobias T. Schmidt, Laura Mainz, Sara Przetocka, Candy Haggblom, Nimesha Tadepalle, April Williams, Maxim N. Shokhirev, Semih C. Akincilar, Vinay Tergaonkar, Gerald S. Shadel, Jan Karlseder
Publikováno v:
Nature. 614:767-773
Cancers arise through the accumulation of genetic and epigenetic alterations that enable cells to evade telomere-based proliferative barriers and achieve immortality. One such barrier is replicative crisis—an autophagy-dependent program that elimin
Autor:
Nazma Malik, Bibiana I. Ferreira, Pablo E. Hollstein, Stephanie D. Curtis, Elijah Trefts, Sammy Weiser Novak, Jingting Yu, Rebecca Gilson, Kristina Hellberg, Lingjing Fang, Arlo Sheridan, Nasun Hah, Gerald S. Shadel, Uri Manor, Reuben J. Shaw
Publikováno v:
Science. 380
Cells respond to mitochondrial poisons with rapid activation of the adenosine monophosphate–activated protein kinase (AMPK), causing acute metabolic changes through phosphorylation and prolonged adaptation of metabolism through transcriptional effe
Autor:
Laura E. Newman, Gerald S. Shadel
Publikováno v:
Annual Review of Biochemistry. 92
According to the endosymbiotic theory, most of the DNA of the original bacterial endosymbiont has been lost or transferred to the nucleus, leaving a much smaller (∼16 kb in mammals), circular molecule that is the present-day mitochondrial DNA (mtDN
Autor:
Qin Yan, Xiang Chen, Gerald S. Shadel, David L. Rimm, David F. Stern, Michael P. DiGiovanna, Keisuke Aoshima, Swati Gupta, Mariana Do Carmo, Lizhen Wu, Sabine M. Lang, Meiling Zhang, Marissa A. Holmbeck, Zongzhi Z. Liu, Jian Cao, Yao Li, Molly Gale
Acquired resistance to HER2-targeted therapies occurs frequently in HER2+ breast tumors and new strategies for overcoming resistance are needed. Here, we report that resistance to trastuzumab is reversible, as resistant cells regained sensitivity to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::742603bf6c8428c05637f9e53de3cb10
https://doi.org/10.1158/0008-5472.c.6512016.v1
https://doi.org/10.1158/0008-5472.c.6512016.v1
Autor:
Qin Yan, Xiang Chen, Gerald S. Shadel, David L. Rimm, David F. Stern, Michael P. DiGiovanna, Keisuke Aoshima, Swati Gupta, Mariana Do Carmo, Lizhen Wu, Sabine M. Lang, Meiling Zhang, Marissa A. Holmbeck, Zongzhi Z. Liu, Jian Cao, Yao Li, Molly Gale
Supplementary Table 2: BT-TR1 versus BT474 RNA sequencing normalized gene expression Supplementary Table 3: BT-TR2 versus BT474 RNA sequencing normalized gene expression Supplementary Table 4: BT-TPR1 versus BT474 RNA sequencing normalized gene expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::325411ac839ced214980806e39f4c086
https://doi.org/10.1158/0008-5472.22425378.v1
https://doi.org/10.1158/0008-5472.22425378.v1
Autor:
Qin Yan, Xiang Chen, Gerald S. Shadel, David L. Rimm, David F. Stern, Michael P. DiGiovanna, Keisuke Aoshima, Swati Gupta, Mariana Do Carmo, Lizhen Wu, Sabine M. Lang, Meiling Zhang, Marissa A. Holmbeck, Zongzhi Z. Liu, Jian Cao, Yao Li, Molly Gale
Supplementary Figure 1: Generation and characterization of resistant cell pools. Supplementary Figure 2: Copy number assessment of receptor tyrosine kinases in resistant cell pools. Supplementary Figure 3: Trastuzumab resistance is reversible. Supple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82650a9bb458b36bd2c75909d032d29d
https://doi.org/10.1158/0008-5472.22425381
https://doi.org/10.1158/0008-5472.22425381