Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Gerald S Horan"'
Autor:
Paul W Noble, Luca Richeldi, David A Lynch, Steven Greenberg, THEODORE F REISS, Zoran Popmihajlov, Donna J Sutherland, Gerald S Horan, Atalanta Ghosh
Publikováno v:
BMJ Open Respiratory Research, Vol 9, Iss 1 (2022)
Externí odkaz:
https://doaj.org/article/c353a750d53f4c1784f7d28572dde2a9
Autor:
Dawen Yu, Zhicheng Zhao, Poshala Aluwihare, Zhenyu Mu, Shelia M. Violette, John S. Munger, Paul H. Weinreb, Gerald S. Horan
Publikováno v:
Journal of Cell Science. 122:227-232
The arginine-glycine-aspartate (RGD)-binding integrins αvβ6 and αvβ8 activate latent TGFβ1 and TGFβ3 in vivo, but it is uncertain whether other RGD-binding integrins such as integrins αvβ5 and αvβ3 activate these TGFβ isoforms. To define t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06d2b26be9a955922be5747ecd51e45e
https://doi.org/10.1242/jcs.035246
https://doi.org/10.1242/jcs.035246
Autor:
Yoriko Sawa, Shelia M. Violette, Amua Carmago, Xin Bernstein, Hong He, Susan V. Lynch, Xiaozhu Huang, Paul H. Weinreb, Yuanlin Song, Gerald S. Horan, Jean-Francois Pittet, Jeanine P. Wiener-Kronish
Publikováno v:
Infection and Immunity. 76:2325-2332
Deletion of integrin αvβ6 has been associated with significant protection in experiments where lung injury was induced by bleomycin, lipophilic polysaccharides, and high tidal volume ventilation. This has led to the suggestion that antibody blockad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db694b26cf0143788bfc52cbf0d173f2
https://doi.org/10.1128/iai.01431-07
https://doi.org/10.1128/iai.01431-07
Autor:
Humphrey Gardner, Allen M. Gown, Diane R. Leone, Glenna Heaney, Carl Reid, Patricia E. McCoon, Rebecca Kelly, Louise A. Koopman Van Aarsen, Kenneth Simon, Steffan Ho, Nianjun Tao, Marilyn Skelly, Stephen E. Fawell, Doreen J. LePage, Gareth J. Thomas, Gerald S. Horan, Paul Rayhorn, Shelia M. Violette, Brian M. Dolinski, Paul H. Weinreb
Publikováno v:
Cancer Research. 68:561-570
The αvβ6 integrin is up-regulated on epithelial malignancies and has been implicated in various aspects of cancer progression. Immunohistochemical analysis of αvβ6 expression in 10 human tumor types showed increased expression relative to normal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5581d3915dde3774d2aab9c9cdeed3d2
https://doi.org/10.1158/0008-5472.can-07-2307
https://doi.org/10.1158/0008-5472.can-07-2307
Autor:
Yi Luo, Raghu Kalluri, Matvey E. Lukashev, Diane R Leone, Roy R. Lobb, Brian M. Dolinski, Li Chun Wang, William Yang, Paul H. Weinreb, Kenneth Simon, Dean Sheppard, Donald J. McCrann, Kyungmin Hahm, Gerald S. Horan, Shelia M. Violette, Agnes B. Fogo, Norm Allaire, Charles F. Shield, Humphrey Gardner
Publikováno v:
The American Journal of Pathology. 170:110-125
The transforming growth factor (TGF)-beta-inducible integrin alpha v beta6 is preferentially expressed at sites of epithelial remodeling and has been shown to bind and activate latent precursor TGF-beta. Herein, we show that alpha v beta6 is overexpr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4851d4538d75f908ff2d217148ce0534
https://doi.org/10.2353/ajpath.2007.060158
https://doi.org/10.2353/ajpath.2007.060158
Autor:
Jennifer Reilly, Victor Koteliansky, Frederick R. Taylor, Darren P. Baker, R B Pepinsky, Paul Rayhorn, Ellen Garber, Kathy Strauch, Gerald S. Horan, Gloria Chi-Rosso, Kevin P. Williams
Publikováno v:
Journal of Cell Science. 112:4405-4414
During development, sonic hedgehog functions as a morphogen in both a short-range contact-dependent and in a long-range diffusable mode. Here, we show using a panel of sonic hedgehog variants that regions near the N terminus of the protein play a cri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1d502b232242a9db26ec10b57b96cee
https://doi.org/10.1242/jcs.112.23.4405
https://doi.org/10.1242/jcs.112.23.4405
Autor:
Poshala, Aluwihare, Zhenyu, Mu, Zhicheng, Zhao, Dawen, Yu, Paul H, Weinreb, Gerald S, Horan, Shelia M, Violette, John S, Munger
Publikováno v:
Journal of cell science. 122(Pt 2)
The arginine-glycine-aspartate (RGD)-binding integrins alphavbeta6 and alphavbeta8 activate latent TGFbeta1 and TGFbeta3 in vivo, but it is uncertain whether other RGD-binding integrins such as integrins alphavbeta5 and alphavbeta3 activate these TGF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f2b71c9631563db86862dfc4dc607c08
https://pubmed.ncbi.nlm.nih.gov/19118215
https://pubmed.ncbi.nlm.nih.gov/19118215
Autor:
Yuanlin, Song, Jean Francois, Pittet, Xiaozhu, Huang, Hong, He, Susan V, Lynch, Shelia M, Violette, Paul H, Weinreb, Gerald S, Horan, Amua, Carmago, Yoriko, Sawa, Xin Liu, Bernstein, Jeanine P, Wiener-Kronish
Publikováno v:
Infection and immunity. 76(6)
Deletion of integrin alphav beta6 has been associated with significant protection in experiments where lung injury was induced by bleomycin, lipophilic polysaccharides, and high tidal volume ventilation. This has led to the suggestion that antibody b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1f04f9abcdb38afe7e888a87d5c1c3fb
https://pubmed.ncbi.nlm.nih.gov/18378634
https://pubmed.ncbi.nlm.nih.gov/18378634
Autor:
Dean Sheppard, Byron Miyazawa, Michael A. Matthay, Marybeth Howard, Shelia M. Violette, Michael T. Ganter, Paul H. Weinreb, George Su, James A. Frank, Jean-Francois Pittet, Jérémie Roux, Gerald S. Horan
Interleukin (IL)-1beta has previously been shown to be among the most biologically active cytokines in the lungs of patients with acute lung injury (ALI). Furthermore, there is experimental evidence that lung vascular permeability increases after sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8dbc706e2cbad2bc6b65519275ac615
https://europepmc.org/articles/PMC2739091/
https://europepmc.org/articles/PMC2739091/
Autor:
Susan Wood, Dean Sheppard, Paul H. Weinreb, Robert Lafyatis, Carol Feghali-Bostwick, Shelia M. Violette, Victor Ona, Xiaozhu Huang, Gerald S. Davis, Norm Allaire, Kenneth Simon, Dan Jun Li, Kyungmin Hahm, Nicola J. Rinaldi, Jaya Goyal, Gerald S. Horan, Carl O'Hara, Matvey E. Lukashev, Eric L. Matteson
Publikováno v:
American journal of respiratory and critical care medicine. 177(1)
Transforming growth factor (TGF)-beta has a central role in driving many of the pathological processes that characterize pulmonary fibrosis. Inhibition of the integrin alpha(v)beta6, a key activator of TGF-beta in lung, is an attractive therapeutic s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4336945e664064ccff9c8040b47767f4
https://pubmed.ncbi.nlm.nih.gov/17916809
https://pubmed.ncbi.nlm.nih.gov/17916809