Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Gerald R. Rhodes"'
Autor:
Kelly L. Robinson, Gerald R. Rhodes, Darius Babusis, Robert Strab, Leah Tong, Siddhartha Bhoopathy, Adrian S. Ray, Truc K. Phan, Ismael J. Hidalgo
Publikováno v:
Antimicrobial Agents and Chemotherapy. 51:3498-3504
Human immunodeficiency virus protease inhibitors (PIs) modestly affect the plasma pharmacokinetics of tenofovir (TFV; −15% to +37% change in exposure) following coadministration with the oral prodrug TFV disoproxil fumarate (TDF) by a previously un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8f3de0e7da9ed2ccf0714a6e832c730
https://doi.org/10.1128/aac.00671-07
https://doi.org/10.1128/aac.00671-07
Publikováno v:
British Journal of Clinical Pharmacology. 59:346-354
Aims Two studies were conducted to evaluate the effects of coadministration of ketoconazole with two nonsedating antihistamines, ebastine and loratadine, on the QTc interval and on the pharmacokinetics of the antihistamines. Methods In both studies h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17dc8b000db35cf9877d0578db21634e
https://doi.org/10.1111/j.1365-2125.2005.02348.x
https://doi.org/10.1111/j.1365-2125.2005.02348.x
Autor:
Frank Deluccia, Gerald R. Rhodes, Shashank Rohatagi, Michael S. Gillen, Philip Chaikin, Donald Banerji
Publikováno v:
The Journal of Clinical Pharmacology. 41:7-18
Oral inhaled corticosteroids are important in the treatment of asthma since their delivery is targeted directly to the lung, which is the site of action. Triamcinolone acetonide (TAA) is an effective and safe corticosteroid that is marketed as a mete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::030a24a26ad22d61231232dba1aaf6a5
https://doi.org/10.1177/00912700122009782
https://doi.org/10.1177/00912700122009782
Publikováno v:
The Journal of Clinical Pharmacology. 40:1428-1438
In a health care environment dominated by the growth of managed care organizations, generic competition, therapeutic substitution and drug utilization review, drug development is an extremely risky proposition. Consequently, it is imperative to incor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e7975b9726a351fbf11a05c6b03d468
https://doi.org/10.1177/009127000004001213
https://doi.org/10.1177/009127000004001213
Autor:
Donald R. Stanski, Wayne A. Colburn, Philip Chaikin, Hartmut Derendorf, Raymond Miller, Gerald R. Rhodes, Jürgen Venitz, Robert L. Powell, Lawrence J. Lesko, Peter Lee
Publikováno v:
The Journal of Clinical Pharmacology. 40:1399-1418
The two domains in clinical pharmacology dealing with optimizing dosing recommendations are pharmacokinetics and pharmacodynamics. However, the usefulness of these disciplines is limited if viewed in isolation. Pharmacokinetic/pharmacodynamic (PK/PD)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e5963fc2229a3a49e66a90961e3b48c
https://doi.org/10.1177/009127000004001211
https://doi.org/10.1177/009127000004001211
Publikováno v:
Clinical Pharmacology & Therapeutics. 68:677-687
Background Pharmacokinetic and pharmacodynamic analyses conducted during the development of docetaxel showed that patients with non–small-cell lung cancer with high baseline α1-acid glycoprotein levels had shorter time to progression and time to d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b4a1fc6b6f7db69e5bcf18434b2c4cf
https://doi.org/10.1067/mcp.2000.111948
https://doi.org/10.1067/mcp.2000.111948
Autor:
Susan L. DePhillips, Shashank Rohatagi, Gerald R. Rhodes, Bradford K. Jensen, Peter N. Zannikos
Publikováno v:
The Journal of Clinical Pharmacology. 40:1129-1140
RGD891 is a platelet GPIIb/IIIa receptor antagonist and potent inhibitor of platelet aggregation. This compound is biotransformed in vivo to RGD039, which also exhibits high affinity for the GPIIb/IIIa receptor. Pharmacokinetic/pharmacodynamic modeli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a8a74b37df889ee95d3c5630762b16a
https://doi.org/10.1177/009127000004001007
https://doi.org/10.1177/009127000004001007
Autor:
Ismael J. Hidalgo, Michael P. Marietta, Zuyu Guo, Gerald R. Rhodes, Yongyi Luo, Glenn L. Dobson
Publikováno v:
Journal of Pharmacy and Pharmacology. 52:957-961
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2e33b1a54024be3ef1f52e4267fbf9
https://doi.org/10.1211/0022357001774840
https://doi.org/10.1211/0022357001774840
Autor:
Nicole Vivier, G. Montay, Larry K. Powe, J. C. Delumeau, Rene Bruno, Gerald R. Rhodes, Aim éLe Liboux
Publikováno v:
Clinical Pharmacology & Therapeutics. 62:518-526
Objectives To characterize the population pharmacokinetic of riluzole in patients with amyotrophic lateral sclerosis (ALS). Methods One hundred patients with ALS who were participating in a multicenter phase III dose-ranging trial of riluzole were sa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb5229af6ccd23328342ae06b91c8888
https://doi.org/10.1016/s0009-9236(97)90047-3
https://doi.org/10.1016/s0009-9236(97)90047-3
Autor:
Philip L. Smith, A. Nichols, Thomas W. Ku, William E. Bondinell, Glynn Wilson, J. Samanen, Chao-Pin Lee, Gerald R. Rhodes
Publikováno v:
Journal of Pharmacy and Pharmacology. 48:119-135
This review discusses both tools and strategies that may be employed as approaches towards the pursuit of orally active compounds from peptidergic molecules. Besides providing a review of these subjects, this paper provides an example of how these we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5af741b2c0bab50ac96bb650166aff3c
https://doi.org/10.1111/j.2042-7158.1996.tb07111.x
https://doi.org/10.1111/j.2042-7158.1996.tb07111.x