Zobrazeno 1 - 10
of 282
pro vyhledávání: '"Gerald R Fink"'
Autor:
Karin Strijbis, Fikadu G Tafesse, Gregory D Fairn, Martin D Witte, Stephanie K Dougan, Nicki Watson, Eric Spooner, Alexandre Esteban, Valmik K Vyas, Gerald R Fink, Sergio Grinstein, Hidde L Ploegh
Publikováno v:
PLoS Pathogens, Vol 9, Iss 6, p e1003446 (2013)
Phagocytosis of the opportunistic fungal pathogen Candida albicans by cells of the innate immune system is vital to prevent infection. Dectin-1 is the major phagocytic receptor involved in anti-fungal immunity. We identify two new interacting protein
Externí odkaz:
https://doaj.org/article/2cd6c464b61041a582a289786a0820d6
Publikováno v:
PLoS Genetics, Vol 8, Iss 6, p e1002732 (2012)
For the yeast Saccharomyces cerevisiae, nutrient limitation is a key developmental signal causing diploid cells to switch from yeast-form budding to either foraging pseudohyphal (PH) growth or meiosis and sporulation. Prolonged starvation leads to li
Externí odkaz:
https://doaj.org/article/b37038b69ed54971809b03d5c17e2eaa
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43210 (2012)
Despite the known relevance of genomic structural variants to pathogen behavior, cancer, development, and evolution, certain repeat based structural variants may evade detection by existing high-throughput techniques. Here, we present ruler arrays, a
Externí odkaz:
https://doaj.org/article/4ee1fa0ba69c4ea59bfa714dde99e484
Publikováno v:
PLoS Biology, Vol 8, Iss 11, p e1000523 (2010)
Cell size increases significantly with increasing ploidy. Differences in cell size and ploidy are associated with alterations in gene expression, although no direct connection has been made between cell size and transcription. Here we show that ploid
Externí odkaz:
https://doaj.org/article/e24f1aac247e4af5b9273cb27dd26175
Publikováno v:
PLoS Pathogens, Vol 4, Iss 12, p e1000227 (2008)
Candida albicans, a clinically important dimorphic fungal pathogen that can evade immune attack by masking its cell wall beta-glucan from immune recognition, mutes protective host responses mediated by the Dectin-1 beta-glucan receptor on innate immu
Externí odkaz:
https://doaj.org/article/fb627352e8c643e3ba0431a4fc25da94
Autor:
Robert T Wheeler, Gerald R Fink
Publikováno v:
PLoS Pathogens, Vol 2, Iss 4, p e35 (2006)
Fungal pathogens can be recognized by the immune system via their beta-glucan, a potent proinflammatory molecule that is present at high levels but is predominantly buried beneath a mannoprotein coat and invisible to the host. To investigate the natu
Externí odkaz:
https://doaj.org/article/312a5d7c9ef04d45a4651cf7cb23d0d0
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Genetic background impacts the phenotypic outcome of a mutation in different individuals; however, the underlying molecular mechanisms are often unclear. We characterized genes exhibiting conditional essentiality when mutated in two gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d51e0fdb597e02381a26aad0d1417cac
http://europepmc.org/articles/PMC6421401
http://europepmc.org/articles/PMC6421401
Autor:
Gregory Stephanopoulos, Felix H. Lam, Burcu Turanlı-Yıldız, Gerald R. Fink, Dany Liu, Michael G. Resch
Publikováno v:
Science Advances
Rationally engineered tolerance enables broadly efficient lignocellulosic fermentation of diverse feedstocks and bioproducts.
Lignocellulosic biomass remains unharnessed for the production of renewable fuels and chemicals due to challenges in de
Lignocellulosic biomass remains unharnessed for the production of renewable fuels and chemicals due to challenges in de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7782c0342c15b7ff4895d3278edba726
https://aperta.ulakbim.gov.tr/record/232864
https://aperta.ulakbim.gov.tr/record/232864
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2020, ⟨10.1093/nar/gkaa468⟩
Nucleic Acids Research, Oxford University Press, 2020, ⟨10.1093/nar/gkaa468⟩
RNA interference (RNAi) is a gene-silencing pathway that can play roles in viral defense, transposon silencing, heterochromatin formation and post-transcriptional gene silencing. Although absent from Saccharomyces cerevisiae, RNAi is present in other
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0024943251f93b26d33529f2e292268
https://hal.archives-ouvertes.fr/hal-03064992
https://hal.archives-ouvertes.fr/hal-03064992
Autor:
Alexandre Esteban, Sudhakar Singh, Manpreet Kaur, Gerald R. Fink, Vincent L. Butty, Dhaneshwar Kumar, Sharvan Sehrawat, Hidde L. Ploegh
Publikováno v:
iScience, Vol 9, Iss, Pp 101-119 (2018)
iScience
iScience
Summary To gain insights into the molecular mechanisms and pathways involved in the activation of γ-herpesvirus (MHV68)-specific T cell receptor transnuclear (TN) CD8+ T cells, we performed a comprehensive transcriptomic analysis. Upon viral infecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ace76f6536cfcd37752a559a21a8ec9
https://doi.org/10.1016/j.isci.2018.10.013
https://doi.org/10.1016/j.isci.2018.10.013