Zobrazeno 1 - 10
of 329
pro vyhledávání: '"Gerald R Crabtree"'
Autor:
Hideo Hagihara, Hirotaka Shoji, Satoko Hattori, Giovanni Sala, Yoshihiro Takamiya, Mika Tanaka, Masafumi Ihara, Mihiro Shibutani, Izuho Hatada, Kei Hori, Mikio Hoshino, Akito Nakao, Yasuo Mori, Shigeo Okabe, Masayuki Matsushita, Anja Urbach, Yuta Katayama, Akinobu Matsumoto, Keiichi I Nakayama, Shota Katori, Takuya Sato, Takuji Iwasato, Haruko Nakamura, Yoshio Goshima, Matthieu Raveau, Tetsuya Tatsukawa, Kazuhiro Yamakawa, Noriko Takahashi, Haruo Kasai, Johji Inazawa, Ikuo Nobuhisa, Tetsushi Kagawa, Tetsuya Taga, Mohamed Darwish, Hirofumi Nishizono, Keizo Takao, Kiran Sapkota, Kazutoshi Nakazawa, Tsuyoshi Takagi, Haruki Fujisawa, Yoshihisa Sugimura, Kyosuke Yamanishi, Lakshmi Rajagopal, Nanette Deneen Hannah, Herbert Y Meltzer, Tohru Yamamoto, Shuji Wakatsuki, Toshiyuki Araki, Katsuhiko Tabuchi, Tadahiro Numakawa, Hiroshi Kunugi, Freesia L Huang, Atsuko Hayata-Takano, Hitoshi Hashimoto, Kota Tamada, Toru Takumi, Takaoki Kasahara, Tadafumi Kato, Isabella A Graef, Gerald R Crabtree, Nozomi Asaoka, Hikari Hatakama, Shuji Kaneko, Takao Kohno, Mitsuharu Hattori, Yoshio Hoshiba, Ryuhei Miyake, Kisho Obi-Nagata, Akiko Hayashi-Takagi, Léa J Becker, Ipek Yalcin, Yoko Hagino, Hiroko Kotajima-Murakami, Yuki Moriya, Kazutaka Ikeda, Hyopil Kim, Bong-Kiun Kaang, Hikari Otabi, Yuta Yoshida, Atsushi Toyoda, Noboru H Komiyama, Seth GN Grant, Michiru Ida-Eto, Masaaki Narita, Ken-ichi Matsumoto, Emiko Okuda-Ashitaka, Iori Ohmori, Tadayuki Shimada, Kanato Yamagata, Hiroshi Ageta, Kunihiro Tsuchida, Kaoru Inokuchi, Takayuki Sassa, Akio Kihara, Motoaki Fukasawa, Nobuteru Usuda, Tayo Katano, Teruyuki Tanaka, Yoshihiro Yoshihara, Michihiro Igarashi, Takashi Hayashi, Kaori Ishikawa, Satoshi Yamamoto, Naoya Nishimura, Kazuto Nakada, Shinji Hirotsune, Kiyoshi Egawa, Kazuma Higashisaka, Yasuo Tsutsumi, Shoko Nishihara, Noriyuki Sugo, Takeshi Yagi, Naoto Ueno, Tomomi Yamamoto, Yoshihiro Kubo, Rie Ohashi, Nobuyuki Shiina, Kimiko Shimizu, Sayaka Higo-Yamamoto, Katsutaka Oishi, Hisashi Mori, Tamio Furuse, Masaru Tamura, Hisashi Shirakawa, Daiki X Sato, Yukiko U Inoue, Takayoshi Inoue, Yuriko Komine, Tetsuo Yamamori, Kenji Sakimura, Tsuyoshi Miyakawa
Publikováno v:
eLife, Vol 12 (2024)
Increased levels of lactate, an end-product of glycolysis, have been proposed as a potential surrogate marker for metabolic changes during neuronal excitation. These changes in lactate levels can result in decreased brain pH, which has been implicate
Externí odkaz:
https://doaj.org/article/15de117935204a21a8487997042e8094
Autor:
Sasha L. Fulton, Wendy Wenderski, Ashley E. Lepack, Andrew L. Eagle, Tomas Fanutza, Ryan M. Bastle, Aarthi Ramakrishnan, Emma C. Hays, Arianna Neal, Jaroslav Bendl, Lorna A. Farrelly, Amni Al-Kachak, Yang Lyu, Bulent Cetin, Jennifer C. Chan, Tina N. Tran, Rachael L. Neve, Randall J. Roper, Kristen J. Brennand, Panos Roussos, John C. Schimenti, Allyson K. Friedman, Li Shen, Robert D. Blitzer, Alfred J. Robison, Gerald R. Crabtree, Ian Maze
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The molecular mechanisms underlying deficits in Down syndrome remain unclear. Here, the authors show that copy number restoration of a chromatin remodeler in trisomic mice is sufficient to rescue epigenomic, physiological and cognitive deficits.
Externí odkaz:
https://doaj.org/article/4d9fc438d0e34047a77c7e2c58308fbb
Autor:
Kai Ni, Jianke Ren, Xiaoping Xu, Yafeng He, Richard Finney, Simon M. G. Braun, Nathaniel A. Hathaway, Gerald R. Crabtree, Kathrin Muegge
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The human ICF 4 syndrome is caused by mutation of the chromatin remodeller LSH. Here, the authors show that LSH depletion disrupts the ability of histone variant macroH2A to insert into chromatin and silence transcription.
Externí odkaz:
https://doaj.org/article/6643f55537234e79b58f4c93aa3e4891
Autor:
Hye-Jin Park, Eric Tsai, Dennis Huang, Michael Weaver, Luciana Frick, Ace Alcantara, John J. Moran, Julia Patzig, Carmen V. Melendez-Vasquez, Gerald R. Crabtree, M.L. Feltri, John Svaren, Patrizia Casaccia
Publikováno v:
iScience, Vol 25, Iss 4, Pp 104132- (2022)
Summary: Cells elaborate transcriptional programs in response to external signals. In the peripheral nerves, Schwann cells (SC) sort axons of given caliber and start the process of wrapping their membrane around them. We identify Actin-like protein 6
Externí odkaz:
https://doaj.org/article/ed55dc312aef4ee89569512edfbce00b
Autor:
Simon M. G. Braun, Jacob G. Kirkland, Emma J. Chory, Dylan Husmann, Joseph P. Calarco, Gerald R. Crabtree
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Understanding the link between epigenetic marks and gene regulation requires the development of new tools to directly manipulate chromatin. Here the authors demonstrate a Cas9-based system to recruit chromatin remodelers to loci of interest, allowing
Externí odkaz:
https://doaj.org/article/ceb7020dd5784ed49c21a33809ac7893
Autor:
Emma A. Morrison, Julio C. Sanchez, Jehnna L. Ronan, Daniel P. Farrell, Katayoun Varzavand, Jenna K. Johnson, Brian X. Gu, Gerald R. Crabtree, Catherine A. Musselman
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
BRG1 and BRM are central components of the BAF (mSWI/SNF) chromatin remodelling complex, which is critical for regulation of chromatin structure. Here, the authors provide evidence that both the BRG1 and hBRM bromodomains have DNA-binding activity an
Externí odkaz:
https://doaj.org/article/3649bcbbddde4952a8a4555506942341
Autor:
Randall J. Platt, Yang Zhou, Ian M. Slaymaker, Ashwin S. Shetty, Niels R. Weisbach, Jin-Ah Kim, Jitendra Sharma, Mitul Desai, Sabina Sood, Hannah R. Kempton, Gerald R. Crabtree, Guoping Feng, Feng Zhang
Publikováno v:
Cell Reports, Vol 19, Iss 2, Pp 335-350 (2017)
Summary: Autism spectrum disorder (ASD) is a heterogeneous disease, but genetically defined models can provide an entry point to studying the molecular underpinnings of this disorder. We generated germline mutant mice with loss-of-function mutations
Externí odkaz:
https://doaj.org/article/aba3bb6682074342a2b284ec87cc7022
Autor:
Livia Ulicna, Samuel C. Kimmey, Christopher M. Weber, Grace M. Allard, Aihui Wang, Nam Q. Bui, Sean C. Bendall, Gerald R. Crabtree, Gregory R. Bean, Capucine Van Rechem
Publikováno v:
Cancer Res
Subunits from the chromatin remodelers mammalian SWItch/Sucrose Non-Fermentable (mSWI/SNF) are mutated, deleted, or amplified in more than 40% of cancers. Understanding their functions in normal cells and the consequences of cancerous alterations wil
Autor:
Calvin J. Kuo, Gerald R. Crabtree, Haian Fu, Andrea Califano, Christina Curtis, Jonathan S. Weissman, Ilya Shmulevich, Jin Chen, Jose A. Seoane, Hang Xu, Alexandra Sockell, Bahar Tercan, Amanda T. Mah, Teri A. Longacre, Sunny J. Jones, Kasper Karlsson, Walter D. Sobba, Ajay Nair, Andrey Krokhotin, Chiung-Ying Chang, Yuhong Du, Kevin S. Kolahi, Yuan-Hung Lo
Supplementary Figure 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::238040cc0fa6f44debc0bae0c1cfd3d8
https://doi.org/10.1158/2159-8290.22540522
https://doi.org/10.1158/2159-8290.22540522
Autor:
Calvin J. Kuo, Gerald R. Crabtree, Haian Fu, Andrea Califano, Christina Curtis, Jonathan S. Weissman, Ilya Shmulevich, Jin Chen, Jose A. Seoane, Hang Xu, Alexandra Sockell, Bahar Tercan, Amanda T. Mah, Teri A. Longacre, Sunny J. Jones, Kasper Karlsson, Walter D. Sobba, Ajay Nair, Andrey Krokhotin, Chiung-Ying Chang, Yuhong Du, Kevin S. Kolahi, Yuan-Hung Lo
Mutations in ARID1A rank among the most common molecular aberrations in human cancer. However, oncogenic consequences of ARID1A mutation in human cells remain poorly defined due to lack of forward genetic models. Here, CRISPR/Cas9-mediated ARID1A kno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0324fe5f679990ae407dcf810fcedab8
https://doi.org/10.1158/2159-8290.c.6549400
https://doi.org/10.1158/2159-8290.c.6549400