Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Gerald Platzer"'
Autor:
Szymon Żerko, Clara Conrad-Billroth, Wiktor Koźmiński, Borja Mateos, Robert Konrat, Gerald Platzer, Dorothea Anrather, Julian Holzinger, Marco Sealey-Cardona
Publikováno v:
Biochemistry
Protein phosphorylation is an abundant post-translational modification (PTM) and an essential modulator of protein functionality in living cells. Intrinsically disordered proteins (IDPs) are particular targets of PTM protein kinases due to their invo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::514a828eb6c12827b4119a3658723ee7
http://europepmc.org/articles/PMC8154273
http://europepmc.org/articles/PMC8154273
Autor:
Moriz Mayer, Julian E. Fuchs, Darryl B. McConnell, Leonhard Geist, Robert Konrat, Gerald Platzer, Jark Boettcher
The study of protein-ligand interactions via protein-based NMR generally relies on the detection of chemical-shift changes induced by ligand binding. However, the chemical shift of the ligand when bound to the protein is rarely discussed, since it is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d50da44ac9f1d89c7ecf7eb5a1af145
https://doi.org/10.1101/2021.11.30.470546
https://doi.org/10.1101/2021.11.30.470546
Autor:
Sven Brüschweiler, Robert Konrat, Julia Schörghuber, Darryl B. McConnell, Gerd Bader, Andreas Beier, Bernhard Wolkerstorfer, Leonhard Geist, Dirk Kessler, Harald Engelhardt, Moriz Mayer, Gerald Platzer, Julian E. Fuchs, Roman J. Lichtenecker
Publikováno v:
Angewandte Chemie (International Ed. in English)
While CH–π interactions with target proteins are crucial determinants for the affinity of arguably every drug molecule, no method exists to directly measure the strength of individual CH–π interactions in drug–protein complexes. Herein, we pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82f4c4ecbf6441f842757fe25e95d829
https://pubmed.ncbi.nlm.nih.gov/32421895
https://pubmed.ncbi.nlm.nih.gov/32421895
Autor:
Thomas C. Schwarz, Robert Konrat, Gerald Platzer, Dennis Kurzbach, Andreas Beier, Francesca Tribuzio
Publikováno v:
Journal of Molecular Biology. 430:2439-2452
Molecular recognition of and by intrinsically disordered proteins (IDPs) is an intriguing and still largely elusive phenomenon. Typically, protein recognition involving IDPs requires either folding upon binding or, alternatively, the formation of "fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eba100fbe092931d55246f3ef06ec1c
https://doi.org/10.1016/j.jmb.2018.04.035
https://doi.org/10.1016/j.jmb.2018.04.035
Autor:
Thomas C. Schwarz, Dennis Kurzbach, Robert Konrat, Agathe Vanas, Andrea G. Flamm, Andreas Beier, Gerald Platzer
Publikováno v:
Physical Chemistry Chemical Physics. 19:10651-10656
A novel statistical analysis of paramagnetic relaxation enhancement (PRE) and paramagnetic relaxation interference (PRI) based nuclear magnetic resonance (NMR) data is proposed based on the computation of correlation matrices. The technique is demons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfb45b2eb1e747efccf98c51e4a349a5
https://doi.org/10.1039/c7cp00430c
https://doi.org/10.1039/c7cp00430c
Autor:
Moriz Mayer, Roman J. Lichtenecker, Bernhard Wolkerstorfer, Sven Brüschweiler, Robert Konrat, Gerald Platzer, Julian E. Fuchs, Harald Engelhardt, Darryl B. McConnell, Julia Schörghuber, Gerd Bader, Leonhard Geist, Andreas Beier, Dirk Kessler
Publikováno v:
Angewandte Chemie. 132:14805-14805
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fa463c2ddf917cac66c36356be582a6
https://doi.org/10.1002/ange.202009454
https://doi.org/10.1002/ange.202009454
Autor:
Dirk Kessler, Robert Konrat, Bernhard Wolkerstorfer, Moriz Mayer, Harald Engelhardt, Roman J. Lichtenecker, Gerald Platzer, Julian E. Fuchs, Leonhard Geist, Julia Schörghuber, Sven Brüschweiler, Gerd Bader, Andreas Beier, Darryl B. McConnell
Publikováno v:
Angewandte Chemie International Edition. 59:14697-14697
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c68349f279ea8cb5df3e583149f6fec
https://doi.org/10.1002/anie.202009454
https://doi.org/10.1002/anie.202009454
Autor:
Patrick Chène, Michael Feichtinger, Fedir Bokhovchuk, Tomáš Sára, Gerald Platzer, Robert Konrat, Borja Mateos
Publikováno v:
Biomolecular Nmr Assignments
Yes associated protein (YAP) is an intrinsically disordered protein that plays a major role in the Hippo pathway, regulating organ size, cell proliferation, apoptosis, and is associated with cancer development. Therefore, the binding between YAP and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e0efeabf8ec6da954ba023b0e24c883
https://phaidra.univie.ac.at/o:953700
https://phaidra.univie.ac.at/o:953700
Autor:
Julia Schörghuber, Robert Konrat, Leonhard Geist, Michael Feichtinger, Frederik Weber, Lukas Scheibelberger, Gerald Platzer, Marilena Bisaccia, Roman J. Lichtenecker
Publikováno v:
Journal of Biomolecular Nmr
In recent years, we developed a toolbox of heavy isotope containing compounds, which serve as metabolic amino acid precursors in the E. coli-based overexpression of aromatic residue labeled proteins. Our labeling techniques show excellent results bot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b908b9a11e278d322d76c54cef501b0
https://doi.org/10.1007/s10858-018-0188-z
https://doi.org/10.1007/s10858-018-0188-z
Publikováno v:
Protein Science. 24:752-761
Using complementary approaches of potentiometry and NMR spectroscopy, we have determined that the equilibrium acid dissociation constant (pKa value) of the arginine guanidinium group is 13.8 ± 0.1. This is substantially higher than that of ∼ 12 of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27cc73d57295e132ac09e9dcf95ba896
https://doi.org/10.1002/pro.2647
https://doi.org/10.1002/pro.2647