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pro vyhledávání: '"Gerald P. Brierley"'
Autor:
Gerald P. Brierley, Ruth A. Altschuld
Publikováno v:
Isolated Adult Cardiomyocytes ISBN: 9780429290541
Isolated Adult Cardiomyocytes
Isolated Adult Cardiomyocytes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bf2e9c2f44330727b1436bcb972231d
https://doi.org/10.1201/9780429290541-3
https://doi.org/10.1201/9780429290541-3
Autor:
Gerald P. Brierley, Dennis W. Jung
Publikováno v:
American Journal of Physiology-Cell Physiology. 277:C1194-C1201
Mitochondria must maintain volume homeostasis in order to carry out oxidative phosphorylation. It has been postulated that the concentration of free Mg2+([Mg2+]) serves as the sensor of matrix volume and regulates a K+-extruding K+/H+antiport (K. D.
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1320(3):310-320
The matrix free magnesium ion concentration, [Mg2+]m, estimated using the fluorescent probe furaptra, averaged 0.67 mM in 15 preparations of beef heart mitochondria containing an average of 21 nmol total Mg2+ per mg protein. [Mg2+]m was compared with
Autor:
Gerald P. Brierley, Dennis W. Jung
Publikováno v:
Journal of Bioenergetics and Biomembranes. 26:527-535
The pathways for the uptake and extrusion of Mg2+ by mitochondria are now well defined, the present evidence suggests that uptake occurs by nonspecific diffusive pathways in response to elevated membrane potential. There is disagreement as to some of
Publikováno v:
Archives of Biochemistry and Biophysics. 311:219-228
Regulation of the mitochondrial permeability transition pore has been investigated following the release of matrix solutes which normally participate in pore regulation. Under these conditions, neither cyclosporin A nor ADP induces pore closure, as j
Publikováno v:
Journal of Biological Chemistry. 267:16274-16282
Heart mitochondria respiring in a sucrose medium containing P(i) show a permeability transition when challenged with Ca2+ and an oxidant such as cumene hydroperoxide. The transition results from the opening of a Ca(2+)-dependent pore and is evidenced
Publikováno v:
Journal of Biological Chemistry. 265:14849-14857
We have developed a model for characterizing calcium handling by the intact cardiac sarcoplasmic reticulum (SR) that yields data consistent with both mathematical simulations of in situ SR Ca2+ uptake and deduced behavior of the Ca2(+)-induced Ca2+ e
Publikováno v:
Biochemistry. 29:4121-4128
The concentration of free Mg2+ in the matrix of isolated heart mitochondria has been monitored by using the fluorescent probe furaptra (mag-fura-2). Beef heart mitochondria respiring in a KCl medium in the absence of external Mg2+ maintain free matri
Autor:
Gerald P. Brierley, Dennis W. Jung
Publikováno v:
Biochemistry. 29:408-415
The fluorescence of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein (BCECF) has been used to follow a K(+)-dependent alkaline shift in the matrix pH (pHi) of isolated heart mitochondria. The K(+)-dependent pHi change has properties consistent with an