Výsledky vyhledávání - "Gerald M. Fuller"

Nuclear Countermeasure Activity of TP508 Linked to Restoration of Endothelial Function and Acceleration of DNA Repair

Autor: Laurie E. Sower, Stephanie M. Moya, Scott D. McVicar, Chris Gammarano, Gerald M. Fuller, Paulina Olszewska, Carla Kantara, Darrell H. Carney, Kempaiah Rayavara, Barbara Olszewska-Pazdrak

Publikováno v: Radiation Research. 186:162-174

There is increasing evidence that radiation-induced damage to endothelial cells and loss of endothelial function may contribute to both acute radiation syndromes and long-term effects of whole-body nuclear irradiation. Therefore, several drugs are be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df48e8f5e8835c4a73eb4dce683a7782
https://doi.org/10.1667/rr14409.1

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Secretion of Oncostatin M by Infiltrating Neutrophils: Regulation of IL-6 and Chemokine Expression in Human Mesothelial Cells

Autor: Suzanne M. Hurst, Sara Owens, Simon Arnett Jones, Rachel M. McLoughlin, James Monslow, Nicholas Topley, Llinos W. Morgan, Gerald M. Fuller

Publikováno v: The Journal of Immunology. 169:5244-5251

Recently, we identified that regulation of leukocyte recruitment by IL-6 requires shedding of the IL-6R from infiltrating neutrophils. In this study, experiments have examined whether other IL-6-related cytokines possess similar properties. Levels of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::726e228fc8bfe1f207f26aad0762d715
https://doi.org/10.4049/jimmunol.169.9.5244

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Concordant and Discordant Interleukin-1–Mediated Signaling in Lung Fibroblast Thy-1 Subpopulations

Autor: Mark MacEwen, Lorena Salazar, Benliu Guo, Anandit Mangalwadi, Gerald M. Fuller, James S. Hagood

Publikováno v: American Journal of Respiratory Cell and Molecular Biology. 26:702-708

Following lung injury or inflammation, fibroblasts mediate either restorative repair or disordered remodeling. Interleukin (IL)-1beta is a key mediator in the transition from injury/inflammation to tissue remodeling, in part through its regulation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79cd3e20d4c8cebb9da16d48faa687eb
https://doi.org/10.1165/ajrcmb.26.6.4547

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The soluble interleukin 6 receptor: mechanisms of production and implications in disease

Autor: Gerald M. Fuller, Simon Arnett Jones, Naoki Yamamoto, Nicholas Topley, Sankichi Horiuchi

Publikováno v: The FASEB Journal. 15:43-58

Interleukin 6 (IL-6) performs a prominent role during disease and has been described as both a pro- and anti-inflammatory cytokine. A key feature in the regulation of IL-6 responses has been the identification of a soluble interleukin 6 receptor (sIL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96261b985a00d92f10da82f2c2defd5c
https://doi.org/10.1096/fj.99-1003rev

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Modification of fibrinogen with poly(ethylene glycol) and its effects on fibrin clot characteristics

Autor: Dale S. Feldman, Thomas H. Barker, M. M. Klinger, James S. Hagood, Gerald M. Fuller

Publikováno v: Journal of Biomedical Materials Research. 56:529-535

The suitability of existing topical fibrin glue preparations for tissue sealing or local drug delivery applications is greatly limited by their poor mechanical properties and the limited capacity of fibrinogen (Fgn) to actively bind growth factors or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c0d7f3532de6d4a1e59850d4c6b49741
https://doi.org/10.1002/1097-4636(20010915)56:4<529::aid-jbm1124>3.0.co

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Interleukin 1β inhibits interleukin 6–mediated rat γ fibrinogen gene expression

Autor: Gerald M. Fuller, Zhixin Zhang

Publikováno v: Blood. 96:3466-3472

Interleukin (IL)-1β and IL-6 are the 2 major inducers of a group of hepatic genes during acute inflammation; however, each cytokine uses different intracellular signaling molecules. In most instances, the 2 cytokines interact positively to enhance h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b46dd2982306f69d6f4c69001dc5ee1
https://doi.org/10.1182/blood.v96.10.3466

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Alcohol at Moderate Levels Decreases Fibrinogen Expression In Vivo and In Vitro

Autor: Gerald M. Fuller, Thomas H. Barker, Zhiqing Wang

Publikováno v: Alcoholism: Clinical and Experimental Research. 23:1927-1932

Background: Consumption of moderate amounts of alcohol has been reported to exert a cardioprotective effect in individuals. The exact mechanism by which this occurs has not been fully explored. Circulating levels of the clotting protein fibrinogen ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b11a8ccc7db0219e0dbc14519687a25d
https://doi.org/10.1111/j.1530-0277.1999.tb04093.x

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Fibrin Fragment Induction of Plasminogen Activator Inhibitor Transcription Is Mediated by Activator Protein-1 Through a Highly Conserved Element

Autor: Charles Vinson, Warren L. Simmons, James S. Hagood, Mitchell A. Olman, Gerald M. Fuller, Kimberly E. White

Publikováno v: Blood. 94:2029-2038

Plasminogen activator inhibitor type-1 (PAI-1), a serine protease inhibitor, affects the processes of fibrinolysis, wound healing, and vascular remodeling. We have demonstrated that PAI-1 transcription is induced by D dimer, a plasmin proteolytic fra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c62bb922713556b1e6213179897320e
https://doi.org/10.1182/blood.v94.6.2029

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