Zobrazeno 1 - 10 of 39 pro vyhledávání: '"Gerald L. Stelmack"'
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Akademický článek
Role of dystrophin in airway smooth muscle phenotype, contraction and lung function.
Autor: Pawan Sharma, Sujata Basu, Richard W Mitchell, Gerald L Stelmack, Judy E Anderson, Andrew J Halayko
Publikováno v: PLoS ONE, Vol 9, Iss 7, p e102737 (2014)
Dystrophin links the transmembrane dystrophin-glycoprotein complex to the actin cytoskeleton. We have shown that dystrophin-glycoprotein complex subunits are markers for airway smooth muscle phenotype maturation and together with caveolin-1, play an
Externí odkaz: https://doaj.org/article/660fb297237746b0bb3d6caf467908cb
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4
Allergen inhalation generates pro-inflammatory oxidised phosphatidylcholine associated with airway dysfunction
Autor: Amir Ravandi, Gail M. Gauvreau, Paul M. O'Byrne, Biniam Kidane, Jason Kindrachuk, Christopher Carlsten, Sadeesh Srinathan, Andrew J. Halayko, Sujata Basu, Christopher D. Pascoe, Gerald L. Stelmack, Mirna Ragheb, Aruni Jha, Min Hyung Ryu, Jignesh Vaghasiya
Publikováno v: The European respiratory journal. 57(2)
Oxidised phosphatidylcholines (OxPCs) are produced under conditions of elevated oxidative stress and can contribute to human disease pathobiology. However, their role in allergic asthma is unexplored. The aim of this study was to characterise the OxP
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0883787529627a7c0ef2181d6a72d3a
https://pubmed.ncbi.nlm.nih.gov/33602878
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5
Oxidized phosphatidylcholines induce multiple functional defects in airway epithelial cells
Autor: Neilloy Roy, Emily Turner-Brannen, Christopher D. Pascoe, Adrian R. West, Andrew J. Halayko, Alexander Schultz, Gerald L. Stelmack
Oxidative stress is a hallmark of numerous airway diseases, contributing to extensive cell and tissue damage. Cell membranes and the airway mucosal lining are rich in phospholipids that are particularly susceptible to oxidative attack, producing bioa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a1c1bd0dffddffc260d7c398ab3e3ea
https://doi.org/10.1101/823666
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6
MicroRNA-200b regulates distal airway development by maintaining epithelial integrity
Autor: Dustin Ameis, Molly Pind, Gerald L. Stelmack, Robin Visser, Andrew J. Halayko, Sujata Basu, Michael F. Jackson, Fuqin Zhu, Landon Falk, Agnes Fresnosa, Vinaya Kumar Siragam, Barbara M. Iwasiow, Naghmeh Khoshgoo, Chelsea Day, Richard Keijzer, Arzu Öztürk, Geoffrey G. Hicks
Publikováno v: Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
miR-200b plays a role in epithelial-to-mesenchymal transition (EMT) in cancer. We recently reported abnormal expression of miR-200b in the context of human pulmonary hypoplasia in congenital diaphragmatic hernia (CDH). Smaller lung size, a lower numb
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9421f64ac25e61b811f3d3a19dc8ca8
https://pubmed.ncbi.nlm.nih.gov/28743913
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7
Caveolin-1 is required for contractile phenotype expression by airway smooth muscle cells
Autor: Helmut Unruh, Andrew J. Halayko, Sophie Bos, Reinoud Gosens, Mark M. Mutawe, Gordon Dueck, Dedmer Schaafsma, Gerald L. Stelmack, William T. Gerthoffer, Johan Zaagsma, Herman Meurs
Publikováno v: Journal of cellular and molecular medicine, 15(11), 2430-2442. Wiley
Journal of Cellular and Molecular Medicine
Airway smooth muscle cells exhibit phenotype plasticity that underpins their ability to contribute both to acute bronchospasm and to the features of airway remodelling in chronic asthma. A feature of mature, contractile smooth muscle cells is the pre
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5549b7f459185b9d3dd59793a7fa658b
https://doi.org/10.1111/j.1582-4934.2010.01246.x
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8
Impairment of mitochondrial respiratory chain activity in aortic endothelial cells induced by glycated low-density lipoprotein
Autor: Ganesh V. Sangle, Andrew J. Halayko, Subir K. Roy Chowdhury, Garry X. Shen, Gerald L. Stelmack, Xueping Xie
Publikováno v: Free Radical Biology and Medicine. 48:781-790
Coronary artery disease (CAD) is the leading cause of mortality in diabetic patients. Mitochondrial dysfunction and increased production of reactive oxygen species (ROS) are associated with diabetes and CAD. Elevated levels of glycated LDL (glyLDL) w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e03f805bc801e46bc60e4ffa0e699b52
https://doi.org/10.1016/j.freeradbiomed.2009.12.017
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9
Expression of the dystrophin-glycoprotein complex is a marker for human airway smooth muscle phenotype maturation
Autor: Andrew J. Halayko, Mark M. Mutawe, Gerald L. Stelmack, Karol D. McNeill, Reinoud Gosens, William T. Gerthoffer, Pawan K. Sharma, Thai Tran, Helmut Unruh
Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology, 294(1), L57-L68. AMER PHYSIOLOGICAL SOC
Airway smooth muscle (ASM) cells may contribute to asthma pathogenesis through their capacity to switch between a synthetic/proliferative and a contractile phenotype. The multimeric dystrophin-glycoprotein complex (DGC) spans the sarcolemma, linking
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80c990e73ce9869ae6d9f302c1e2db69
https://doi.org/10.1152/ajplung.00378.2007
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10
Laminin-Binding Integrin α7 Is Required for Contractile Phenotype Expression by Human Airway Myocytes
Autor: Helmut Unruh, Karol D. McNeill, Andrew J. Halayko, Karen Ens-Blackie, Edward S. Rector, Gerald L. Stelmack, William T. Gerthoffer, Guido Tarone, Thai Tran
Publikováno v: American Journal of Respiratory Cell and Molecular Biology. 37:668-680
Contractile airway smooth muscle (ASM) cells retain the ability for phenotype plasticity in response to multiple stimuli, which equips them with capacity to direct modeling and remodeling during development, and in disease states such as asthma. We h
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33f99a1f9763cb5fcbf3fbe91157ca74
https://doi.org/10.1165/rcmb.2007-0165oc
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