Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Gerald J. Shami"'
Autor:
Jiahong Li, Gerald J. Shami, Benjamin Liffner, Ellie Cho, Filip Braet, Manoj T. Duraisingh, Sabrina Absalon, Matthew W. A. Dixon, Leann Tilley
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Plasmodium falciparum is the causative agent of malaria and remains a pathogen of global importance. Asexual blood stage replication, via a process called schizogony, is an important target for the development of new antimalarials. Here we u
Externí odkaz:
https://doaj.org/article/16e0381c3af445ca9a233aecf586db04
Autor:
Jiahong Li, Gerald J. Shami, Ellie Cho, Boyin Liu, Eric Hanssen, Matthew W. A. Dixon, Leann Tilley
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The sexual blood stages of Plasmodium falciparum develop through five morphologically distinct stages culminating in mature crescent-shaped gametocytes that can be transmitted from the mammalian host to the mosquito vector. Here, Li et al. apply diff
Externí odkaz:
https://doaj.org/article/ff99e44bc1534cc68c8958bdad24e894
Autor:
Benjamin Liffner, Juan Miguel Balbin, Gerald J. Shami, Ghizal Siddiqui, Jan Strauss, Sonja Frölich, Gary K. Heinemann, Ella May Edwards, Arne Alder, Jan Stephan Wichers, Darren J. Creek, Leann Tilley, Matthew W. A. Dixon, Tim-Wolf Gilberger, Danny W. Wilson
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-17 (2022)
Benjamin Liffner and Miguel Balbin et al. report that the Plasmodium falciparum protein, PfCERLI2, localises to the cytosolic face of the parasite’s rhoptry bulb and is essential for invasion and growth within human red blood cells.
Externí odkaz:
https://doaj.org/article/70f7a6eab0ab4db184482b483285f76e
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Giant mitochondria are peculiarly shaped, extremely large mitochondria in hepatic parenchymal cells, the internal structure of which is characterised by atypically arranged cristae, enlarged matrix granules and crystalline inclusions. The pr
Externí odkaz:
https://doaj.org/article/6eff5c13dbb24d7683b36c414e0888d2
Autor:
Madel V. Tutor, Gerald J. Shami, Ghizal Siddiqui, Darren J. Creek, Leann Tilley, Stuart A. Ralph
Artemisinin (ART) is a quick-killing and effective antimalarial activated by the haem derived from haemoglobin digestion. Mutations in the parasite’s Kelch 13 (K13) protein compromise the efficacy of this drug. Recent studies indicate an undefined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1b99b6a1f61bd87f4fe797d7ee080d6
https://doi.org/10.1101/2023.03.30.534478
https://doi.org/10.1101/2023.03.30.534478
Autor:
Yawei Du, Carlo Giannangelo, Wei He, Gerald J. Shami, Wenya Zhou, Tuo Yang, Darren J. Creek, Con Dogovski, Xinsong Li, Leann Tilley
Publikováno v:
Antimicrob Agents Chemother
Current best practice for the treatment of malaria relies on short half-life artemisinins that are failing against emerging Kelch 13 mutant parasite strains. Here, we introduce a liposome-like self-assembly of a dimeric artesunate glycerophosphocholi
Autor:
Adam J. Blanch, Boyin Liu, Matthew W. A. Dixon, Gerald J. Shami, Olivia M. S. Carmo, Leann Tilley, Snigdha Tiash, Dezerae Cox
Presentation of the variant antigen,Plasmodium falciparumerythrocyte membrane protein 1 (EMP1), at knob-like protrusions on the surface of infected red blood cells, underpinsP. falciparummalaria pathogenicity. Here we describe a protein PF3D7_0301700
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3c30f13f9e9fa5204472fcd42b270d1
https://doi.org/10.1101/2021.08.12.456062
https://doi.org/10.1101/2021.08.12.456062
Autor:
Jan Strauss, Leann Tilley, Benjamin Liffner, Arne Alder, Matthew W. A. Dixon, Danny W. Wilson, Gerald J. Shami, Tim-Wolf Gilberger, Juan Miguel Balbin, Jan Stephan Wichers, Sonja Frölich, Gary K. Heinemann
Merozoite invasion of host red blood cells (RBCs) is essential for survival of the human malaria parasitePlasmodium falciparum. Proteins involved with RBC binding and invasion are secreted from dual-club shaped organelles at the apical tip of the mer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::039ea7ff2dd95cb9c1506dff33b8b142
https://doi.org/10.1101/2020.11.26.400549
https://doi.org/10.1101/2020.11.26.400549
Publikováno v:
Micron (Oxford, England : 1993). 132
Kupffer cells are liver-resident macrophages that play an important role in mediating immune-related functions in mammals and humans. They are well-known for their capacity to phagocytose large amounts of waste complexes, cell debris, microbial parti
To-date, different electron microscopy (EM) approaches are available (e.g., TEM, SEM, STEM, CLEM, etc.) to collect three-dimensional (3-D) information in tissues and cells from the microscale up to the nanometer scale. However, an abundant amount of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14cdff853b08469778f5d88be45c849f
https://doi.org/10.1016/bs.mcb.2019.03.012
https://doi.org/10.1016/bs.mcb.2019.03.012