Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Gerald J. Roth"'
Autor:
Wolfgang J. Rettig, Armin Heckel, Jens Quant, Andreas Zoephel, Gerd Bader, Pilar Garin-Chesa, Ulrike Tontsch-Grunt, Wolfgang Sommergruber, Susanna Kautschitsch, Martin Krssak, Gerald J. Roth, Frank Hilberg
Inhibition of tumor angiogenesis through blockade of the vascular endothelial growth factor (VEGF) signaling pathway is a novel treatment modality in oncology. Preclinical findings suggest that long-term clinical outcomes may improve with blockade of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15b6ea2186679c686773cc82eb8804b8
https://doi.org/10.1158/0008-5472.c.6497339
https://doi.org/10.1158/0008-5472.c.6497339
Autor:
Wolfgang J. Rettig, Armin Heckel, Jens Quant, Andreas Zoephel, Gerd Bader, Pilar Garin-Chesa, Ulrike Tontsch-Grunt, Wolfgang Sommergruber, Susanna Kautschitsch, Martin Krssak, Gerald J. Roth, Frank Hilberg
Supplementary Methods, Figure 1, Table 1 from BIBF 1120: Triple Angiokinase Inhibitor with Sustained Receptor Blockade and Good Antitumor Efficacy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dc987044139262ecca31c9b8b23fd85
https://doi.org/10.1158/0008-5472.22374101.v1
https://doi.org/10.1158/0008-5472.22374101.v1
Autor:
Patrick Baum, Ramona Schmid, Carina Ittrich, Werner Rust, Katrin Fundel-Clemens, Susanne Siewert, Martin Baur, Lisa Mara, Lore Gruenbaum, Armin Heckel, Roland Eils, Roland E Kontermann, Gerald J Roth, Florian Gantner, Andreas Schnapp, John E Park, Andreas Weith, Karsten Quast, Detlev Mennerich
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e14272 (2010)
A phenocopy is defined as an environmentally induced phenotype of one individual which is identical to the genotype-determined phenotype of another individual. The phenocopy phenomenon has been translated to the drug discovery process as phenotypes p
Externí odkaz:
https://doaj.org/article/7e2fb73d5ce749f599c79099e9a76b50
Publikováno v:
Chest. 133:199S-233S
This article about currently available antiplatelet drugs is part of the Antithrombotic and Thrombolytic Therapy: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). It describes the mechanism of action, ph
Publikováno v:
Blood. 91:1295-1303
The initiation of primary hemostasis is mediated by interaction of the platelet glycoprotein Ib (GPIb) surface receptor and its arterial subendothelial von Willebrand factor (vWF) ligand. The intracellular signaling immediately following GPIb recepto
Publikováno v:
Biochemistry. 34:16132-16137
Human platelet glycoproteins Ib alpha, Ib beta, V, and IX comprise an interrelated set of molecules (the Ib-V-IX system) that together form a surface adhesion receptor for the ligand, von Willebrand factor. To complete the primary structural characte
Publikováno v:
Blood. 86:1361-1367
Platelet adhesion to an injured blood vessel wall is a critical initiating step in hemostasis mediated by a four member receptor complex (glycoprotein Ib/V/IX) interacting with plasma von Willebrand factor (vWF). The function of the GPV subunit withi
Publikováno v:
Journal of Biological Chemistry. 269:17424-17427
Human platelet glycoprotein Ib beta (GPIb beta) (M(r) 22,000) is part of the GPIb-V-IX system that constitutes the receptor for von Willebrand factor and mediates platelet adhesion in the arterial circulation. The four members of the receptor (GPs Ib
Autor:
M J Hickey, Gerald J. Roth
Publikováno v:
Journal of Biological Chemistry. 268:3438-3443
Glycoprotein IX is a relatively small (M(r) 20,000) surface glycoprotein of human platelets; one of three (Ib alpha, Ib beta, IX) polypeptide chains present in the glycoprotein Ib-IX complex that functions as the von Willebrand factor receptor and me
Autor:
Mayumi Yagi, Carl Storey, Stephen H. Bartelmez, Gerald J. Roth, Ewa Sitnicka, Kindred A. Ritchie
The hematopoietic stem cell (HSC) is defined as a cell that can either self-replicate or generate daughter cells that are destined to commit to mature cells of different specific lineages. Self-replication of the most primitive HSC produces daughter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56381bf26fd143e499dbf194992fbcdb
https://europepmc.org/articles/PMC22199/
https://europepmc.org/articles/PMC22199/