Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Gerald J. Fiacco"'
Autor:
Hobart W. Walling, Mary F. Ruh, Gerald J. Fiacco, John J. Jeffrey, Nicola C. Partridge, O. Y. Barmina
Publikováno v:
Archives of Biochemistry and Biophysics. 382:182-188
Since estrogen is important in preventing osteoporosis in postmenopausal women and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is an estrogen antagonist in reproductive tissues, we investigated the effects of 17beta-estradiol (E2) and TCDD on collagen
Publikováno v:
Journal of Cellular Physiology. 181:479-488
We investigated the regulation of collagenase-3 expression in normal, differentiating rat osteoblasts. Fetal rat calvarial cell cultures showed an increase in alkaline phosphatase activity reaching maximal levels between 7–14 days postconfluence, t
Autor:
O. Y. Barmina, John J. Jeffrey, Hobart W. Walling, Gerald J. Fiacco, José M.P. Freije, Nicola C. Partridge, Carlos López-Otín
Publikováno v:
Journal of Biological Chemistry. 274:30087-30093
We have previously identified a specific receptor for collagenase-3 that mediates the binding, internalization, and degradation of this ligand in UMR 106-01 rat osteoblastic osteosarcoma cells. In the present study, we show that collagenase-3 binding
Autor:
Gerald J. Fiacco, John J. Jeffrey, Hobart W. Walling, Terry H. Omura, P. T. Chan, Nicola C. Partridge, O. Y. Barmina
Publikováno v:
Journal of Cellular Physiology. 177:563-574
We have previously described a specific, saturable receptor for rat collagenase-3 in the rat osteosarcoma cell line, UMR 106-01. Binding of rat collagenase-3 to this receptor is coupled to the internalization and eventual degradation of the enzyme an
Autor:
B. Sipe, L. A. Gershan, John J. Jeffrey, B. A. Davis, Nicola C. Partridge, Gerald J. Fiacco, T. C. Lorenz
Publikováno v:
Calcified tissue international. 63(5)
Exposure to zero gravity has been shown to cause a decrease in bone formation. This implicates osteoblasts as the gravity-sensing cell in bone. Osteoblasts also are known to produce neutral proteinases, including collagenase and tissue plasminogen ac