Zobrazeno 1 - 10
of 211
pro vyhledávání: '"Gerald J, Atkins"'
Autor:
Deepti K. Sharma, Balamurugan Ramadass, Stuart A. Callary, Anthony Meade, Rishikesh Dash, Robyn Clothier, Gerald J. Atkins, L. Bogdan Solomon, Boopalan Ramasamy
Publikováno v:
Nutrition Journal, Vol 23, Iss 1, Pp 1-9 (2024)
Abstract Background Prosthetic Joint Infection (PJI) is the most devastating complication of arthroplasty surgery and affects 1–5% of patients. Despite strict adherence to aseptic protocols and preventive measures, infection is the most common reas
Externí odkaz:
https://doaj.org/article/e5a383d67c5641259a123b84be9e2adf
Autor:
Qi Sun, Kimberley Huynh, Dzenita Muratovic, Nicholas J Gunn, Anja R Zelmer, Lucian Bogdan Solomon, Gerald J Atkins, Dongqing Yang
Publikováno v:
eLife, Vol 13 (2024)
Examination of bacteria/host cell interactions is important for understanding the aetiology of many infectious diseases. The colony forming unit (CFU) has been the standard for quantifying bacterial burden for the past century, however, this suffers
Externí odkaz:
https://doaj.org/article/840b99c4903e4c7ea04c9639a099e545
Autor:
Nicholas J. Gunn, Stephen P. Kidd, Lucian B. Solomon, Dongqing Yang, Eugene Roscioli, Gerald J. Atkins
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
Staphylococcus aureus is a major causative pathogen of osteomyelitis. Intracellular infections of resident bone cells including osteocytes can persist despite gold-standard clinical intervention. The mechanisms by which intracellular S. aureus evades
Externí odkaz:
https://doaj.org/article/7bced74367a546d7991f63ea5653114a
Autor:
Jonghoo Sung, Kate R. Barratt, Stephen M. Pederson, Chantal Chenu, Ines Reichert, Gerald J. Atkins, Paul H. Anderson, Peter J. Smitham
Publikováno v:
Bone & Joint Research, Vol 12, Iss 10, Pp 657-666 (2023)
Aims: Impaired fracture repair in patients with type 2 diabetes mellitus (T2DM) is not fully understood. In this study, we aimed to characterize the local changes in gene expression (GE) associated with diabetic fracture. We used an unbiased approach
Externí odkaz:
https://doaj.org/article/744044a5c9934d508ce9a8976a417233
Autor:
Anja R. Zelmer, Yolandi Starczak, Lucian B. Solomon, Katharina Richter, Dongqing Yang, Gerald J. Atkins
Publikováno v:
Physiological Reports, Vol 11, Iss 21, Pp n/a-n/a (2023)
Abstract The intracellular infection of osteocytes represents a clinically important aspect of osteomyelitis. However, few human osteocyte in vitro models exist and the differentiation of immature osteoblasts to an osteocyte stage typically takes at
Externí odkaz:
https://doaj.org/article/6a4b6a505a314412931e9135db5c8e14
Autor:
Renee T. Ormsby, Kunihiro Hosaka, Andreas Evdokiou, Andreani Odysseos, David M. Findlay, Lucian B. Solomon, Gerald J. Atkins
Publikováno v:
Prosthesis, Vol 4, Iss 3, Pp 480-489 (2022)
Polyethylene (PE) liners are a common bearing surface of orthopaedic prostheses. Wear particles of ultra-high molecular weight PE (UHMWPE) contribute to periprosthetic osteolysis, a major cause of aseptic loosening. Vitamin E is added to some PE line
Externí odkaz:
https://doaj.org/article/a791f0e73ed54daba06f3d1af38dc229
Publikováno v:
Bone Research, Vol 10, Iss 1, Pp 1-18 (2022)
Abstract Approximately 40% of treatments of chronic and recurrent osteomyelitis fail in part due to bacterial persistence. Staphylococcus aureus, the predominant pathogen in human osteomyelitis, is known to persist by phenotypic adaptation as small-c
Externí odkaz:
https://doaj.org/article/a92142aed65346fbb2e49575e0ab6d05
Autor:
Matthew Prideaux, Christian S. Wright, Megan L. Noonan, Xin Yi, Erica L. Clinkenbeard, Elsa Mevel, Jonathan A. Wheeler, Sharon Byers, Asiri R. Wijenayaka, Stan Gronthos, Uma Sankar, Kenneth E. White, Gerald J. Atkins, William R. Thompson
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Mesenchymal progenitors differentiate into several tissues including bone, cartilage, and adipose. Targeting these cells in vivo is challenging, making mesenchymal progenitor cell lines valuable tools to study tissue development. Mesenchymal
Externí odkaz:
https://doaj.org/article/f7398838cd214c8aba8d0dac83a09d11
Autor:
Nicholas J. Gunn, Anja R. Zelmer, Stephen P. Kidd, Lucian B. Solomon, Eugene Roscioli, Dongqing Yang, Gerald J. Atkins
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Infectious osteomyelitis associated with periprosthetic joint infections is often recalcitrant to treatment and has a high rate of recurrence. In the case of Staphylococcus aureus, the most common pathogen in all forms of osteomyelitis, this may be a
Externí odkaz:
https://doaj.org/article/a84e56ee3edb4b59898406cc37412815
Autor:
Daniel F. Edwards III, Christopher J. Miller, Arelis Quintana‐Martinez, Christian S. Wright, Matthew Prideaux, Gerald J. Atkins, William R. Thompson, Erica L. Clinkenbeard
Publikováno v:
JBMR Plus, Vol 5, Iss 9, Pp n/a-n/a (2021)
ABSTRACT Bone marrow mesenchymal progenitor cells are precursors for various cell types including osteoblasts, adipocytes, and chondrocytes. The external environment and signals act to direct the pathway of differentiation. Importantly, situations su
Externí odkaz:
https://doaj.org/article/3ef88eb5da434f4f87bbb911db2b3e01