Zobrazeno 1 - 10
of 640
pro vyhledávání: '"Gerald I, Shulman"'
Autor:
Weiwei Xu, Dongyan Zhang, Yumin Ma, Rafael C. Gaspar, Mario Kahn, Ali Nasiri, Sue Murray, Varman T. Samuel, Gerald I. Shulman
Publikováno v:
Cell Reports, Vol 43, Iss 10, Pp 114746- (2024)
Summary: Inhibition of the ceramide synthetic pathway with myriocin or an antisense oligonucleotide (ASO) targeting dihydroceramide desaturase (DES1) both improved hepatic insulin sensitivity in rats fed either a saturated or unsaturated fat diet and
Externí odkaz:
https://doaj.org/article/00431b29c5db46a6873e232ec0b4b288
Autor:
Seiichiro Ohgaku, Shogo Ida, Natsuko Ohashi, Katsutaro Morino, Atsushi Ishikado, Tsuyoshi Yanagimachi, Koichiro Murata, Daisuke Sato, Satoshi Ugi, Ali Nasiri, Gerald I. Shulman, Hiroshi Maegawa, Shinji Kume, Yukihiro Fujita
Publikováno v:
Heliyon, Vol 10, Iss 14, Pp e34490- (2024)
Introduction: Endothelial cells have a crucial function in transporting and exchanging various nutrients. O-GlcNAcylation, mediated by O-GlcNAc transferase (OGT), involves the addition of N-acetylglucosamine to proteins and serves as an intracellular
Externí odkaz:
https://doaj.org/article/190378ccdc7a445c9e011d3f60bd64c6
Autor:
Leigh Goedeke, Alberto Canfrán-Duque, Noemi Rotllan, Balkrishna Chaube, Bonne M. Thompson, Richard G. Lee, Gary W. Cline, Jeffrey G. McDonald, Gerald I. Shulman, Miguel A. Lasunción, Yajaira Suárez, Carlos Fernández-Hernando
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
The mechanisms governing cholesterol homeostasis remain incompletely understood. Here, the authors develop an integrative genomic strategy to identify MMAB, and enzyme in the adenosylcobalamin pathway, as a regulator of hepatic LDLR activity and chol
Externí odkaz:
https://doaj.org/article/822cd3ae48234a3c882c3e30c74ffa1c
Autor:
Tina Schumann, Jörg König, Christian von Loeffelholz, Daniel F. Vatner, Dongyan Zhang, Rachel J. Perry, Michel Bernier, Jason Chami, Christine Henke, Anica Kurzbach, Nermeen N. El-Agroudy, Diana M. Willmes, Dominik Pesta, Rafael de Cabo, John F. O´Sullivan, Eric Simon, Gerald I. Shulman, Bradford S. Hamilton, Andreas L. Birkenfeld
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
Schumann et al. demonstrate that the loss of a lactate transporter Slc16a13 increases mitochondrial respiration in the liver, which reduces hepatic lipid accumulation while increasing hepatic insulin sensitivity in mice fed a high-fat diet. This stud
Externí odkaz:
https://doaj.org/article/7ba53b89a38d4e43a575de6ad202ef08
Autor:
Abudukadier Abulizi, Daniel F. Vatner, Zhang Ye, Yongliang Wang, Joao-Paulo Camporez, Dongyan Zhang, Mario Kahn, Kun Lyu, Alaa Sirwi, Gary W. Cline, M. Mahmood Hussain, Patricia Aspichueta, Varman T. Samuel, Gerald I. Shulman
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 12, Pp 1565-1576 (2020)
Microsomal triglyceride transfer protein (MTTP) deficiency results in a syndrome of hypolipidemia and accelerated NAFLD. Animal models of decreased hepatic MTTP activity have revealed an unexplained dissociation between hepatic steatosis and hepatic
Externí odkaz:
https://doaj.org/article/4a127f1e875f4bd1bff152707a536e82
Autor:
Yanrui Huang, Jenny H. Zhou, Haifeng Zhang, Alberto Canfran-Duque, Abhishek K. Singh, Rachel J. Perry, Gerald I. Shulman, Carlos Fernandez-Hernando, Wang Min
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 9 (2022)
Brown adipose tissue (BAT), a crucial heat-generating organ, regulates whole-body energy metabolism by mediating thermogenesis. BAT inflammation is implicated in the pathogenesis of mitochondrial dysfunction and impaired thermogenesis. However, the l
Externí odkaz:
https://doaj.org/article/48b2ea93ba4c4ec188091528c1218fe1
Publikováno v:
JCI Insight, Vol 7, Iss 7 (2022)
Background Nonalcoholic fatty liver affects 25% to 30% of the US and European populations; is associated with insulin resistance (IR), type 2 diabetes, and increased cardiovascular risk; and is defined by hepatic triglyceride (HTG) content greater th
Externí odkaz:
https://doaj.org/article/70bbdce028414b128c4cf3dc7bdf4df3
Autor:
Neha Bhat, Anand Narayanan, Mohsen Fathzadeh, Mario Kahn, Dongyan Zhang, Leigh Goedeke, Arpita Neogi, Rebecca L. Cardone, Richard G. Kibbey, Carlos Fernandez-Hernando, Henry N. Ginsberg, Dhanpat Jain, Gerald I. Shulman, Arya Mani
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 3 (2022)
Mutations in Dyrk1b are associated with metabolic syndrome and nonalcoholic fatty liver disease in humans. Our investigations showed that DYRK1B levels are increased in the liver of patients with nonalcoholic steatohepatitis (NASH) and in mice fed wi
Externí odkaz:
https://doaj.org/article/081ebed6b4d0408c85b832ff0ab525fb
Autor:
Rachel J. Perry, Aviva Rabin-Court, Joongyu D. Song, Rebecca L. Cardone, Yongliang Wang, Richard G. Kibbey, Gerald I. Shulman
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
The use of sodium-glucose transport protein 2 (SGLT2) inhibitors for the treatment of diabetes has been associated with euglycemic ketoacidosis and increased glucose production and glucagon secretion. Here Perry et al. show that these effects rely on
Externí odkaz:
https://doaj.org/article/1491a567866a435e9938ca80389140c5
Autor:
Leigh Goedeke, Gerald I. Shulman
Publikováno v:
Molecular Metabolism, Vol 46, Iss , Pp 101178- (2021)
Background: Mitochondrial uncouplers shuttle protons across the inner mitochondrial membrane via a pathway that is independent of adenosine triphosphate (ATP) synthase, thereby uncoupling nutrient oxidation from ATP production and dissipating the pro
Externí odkaz:
https://doaj.org/article/0e67ffde4fc14f20ad201f9478ccd81c