Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Gerald Horan"'
Autor:
Rajula Gaur, Kofi A. Mensah, Jason Stricker, Mary Adams, Anastasia Parton, Dorota Cedzik, Jamie Connarn, Michael Thomas, Gerald Horan, Peter Schafer, Stuart Mair, Maria Palmisano, Francisco Ramírez-Valle
Publikováno v:
Arthritis Research & Therapy, Vol 24, Iss 1, Pp 1-15 (2022)
Abstract Background Mitogen-activated protein kinase (MAPK)-activated protein kinase-2 (MK2) is activated downstream of p38 MAPK and regulates stability of mRNAs encoding inflammatory cytokines. CC-99677 is a novel, irreversible, covalent MK2 inhibit
Externí odkaz:
https://doaj.org/article/bbdb650c3cdc4da7b9496d707ec64951
Autor:
Peter H. Schafer, Mary Adams, Gerald Horan, Francesca Truzzi, Alessandra Marconi, Carlo Pincelli
Publikováno v:
Drugs in R&D, Vol 19, Iss 4, Pp 329-338 (2019)
Abstract Background Apremilast, an oral phosphodiesterase (PDE) 4 inhibitor, has demonstrated efficacy in psoriasis, while its efficacy in atopic dermatitis (AD) was found to be modest. AD is a chronic inflammatory skin disease associated with activa
Externí odkaz:
https://doaj.org/article/6311f234a8234e55843aa86a3e9e665f
Autor:
Ying, Ye, Allison, Gaudy, Michael, Thomas, Josephine, Reyes, Barbara, Burkhardt, Gerald, Horan, Liangang, Liu, Jian, Chen, Atalanta, Ghosh, Leonidas N, Carayannopoulos, Daniel A, Tatosian, Maria, Palmisano
Publikováno v:
Clinical Pharmacology in Drug Development. 11:1394-1404
CC-90001 selectively inhibits c-Jun N-terminal kinase (JNK), a stress-activated protein implicated in fibrosis. In 3 phase 1 trials evaluating CC-90001 pharmacokinetics, pharmacodynamics, and safety, healthy adults (N = 184) received oral CC-90001 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9e76922352cef31abbd395278d3c483
https://doi.org/10.1002/cpdd.1178
https://doi.org/10.1002/cpdd.1178
Autor:
Rajula Gaur, Kofi A. Mensah, Jason Stricker, Mary Adams, Anastasia Parton, Dorota Cedzik, Jamie Connarn, Michael Thomas, Gerald Horan, Peter Schafer, Stuart Mair, Maria Palmisano, Francisco Ramírez-Valle
Publikováno v:
Arthritis researchtherapy. 24(1)
Background Mitogen-activated protein kinase (MAPK)-activated protein kinase-2 (MK2) is activated downstream of p38 MAPK and regulates stability of mRNAs encoding inflammatory cytokines. CC-99677 is a novel, irreversible, covalent MK2 inhibitor under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef050bcc3ca5fcaf6872e84b4faeab30
https://pubmed.ncbi.nlm.nih.gov/35982464
https://pubmed.ncbi.nlm.nih.gov/35982464
Autor:
Gerald Horan, Alessandra Marconi, Carlo Pincelli, Peter H. Schafer, Francesca Truzzi, Mary Adams
Publikováno v:
Drugs in R&D, Vol 19, Iss 4, Pp 329-338 (2019)
Drugs in R&D
Drugs in R&D
Background Apremilast, an oral phosphodiesterase (PDE) 4 inhibitor, has demonstrated efficacy in psoriasis, while its efficacy in atopic dermatitis (AD) was found to be modest. AD is a chronic inflammatory skin disease associated with activation of T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10ac5041327daf90544ad0d727d9db8b
https://hdl.handle.net/11380/1182980
https://hdl.handle.net/11380/1182980
Autor:
Brydon L. Bennett, Gerald Horan, Steven Greenberg, Kate Blease, Francisco Ramírez-Valle, Peter H. Schafer, Ada Azaryan, Ralph Ceres, Ying Ye
Publikováno v:
Diffuse Parenchymal Lung Disease.
Aims/Objectives: Although recently approved treatments for IPF delay lung function decline, novel therapeutic options are needed. c-Jun N-terminal kinase (JNK), a stress-activated protein kinase, has been implicated in pulmonary fibrosis (PF) (Alcorn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa86ea896b3e0b594fd1f97f75f36a2e
https://doi.org/10.1183/1393003.congress-2017.oa474
https://doi.org/10.1183/1393003.congress-2017.oa474
Autor:
Robyn T. Domsic, Virginia D. Steen, Vivien Hsu, Daniel E. Furst, Peter H. Schafer, Alyse Cooper, Shimon Korish, Gerald Horan, Douglas R. Hough, Suktae Choi, Marina Stanislav, Maureen Rischmueller, Christopher P. Denton, Jörg H W Distler
Publikováno v:
The Journal of rheumatology. 45(3)
Objective.To evaluate the safety and efficacy of pomalidomide (POM) on forced vital capacity (FVC), modified Rodnan skin score (mRSS), and gastrointestinal (GI) symptomatology over 52 weeks of treatment in patients with interstitial lung disease due
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68b2da20e283d9b9b4f7ee32514cea0e
https://pubmed.ncbi.nlm.nih.gov/29496914
https://pubmed.ncbi.nlm.nih.gov/29496914
Autor:
Mahmoud Assaf, Jos van der Velden, Nasreen Khalil, Peter H. Schafer, Ying Ye, William T. Smith, Gerald Horan, Rajesh Chopra, Maria Palmisano, Peng Chen, Yvonne M. W. Janssen-Heininger, Sidra M. Hoffman, Brydon L. Bennett, Zebulun Horowitz, R. Stevens, Sarah Abdalla, Karolyn G. Lahue, Donna Sutherland, James D. Nolin, Yong Liu, David G. Chapman
Publikováno v:
Clinical and Translational Medicine
Background Lung remodeling and pulmonary fibrosis are serious, life-threatening conditions resulting from diseases such as chronic severe asthma and idiopathic pulmonary fibrosis (IPF). Preclinical evidence suggests that JNK enzyme function is requir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::398cdbb0b157c2291e7780fcbc8ffb6b
https://hdl.handle.net/10453/130399
https://hdl.handle.net/10453/130399
Autor:
Annalisa Saltari, M. Quadri, Ling-Hua Zhang, Alessandra Marconi, Anastasia Parton, Carlo Pincelli, Peter H. Schafer, Roberta Lotti, Gerald Horan, Lei Wu, Jolanta Kosek, Francesca Truzzi
Publikováno v:
Cellular Signalling. (7):753-763
Phosphodiesterases 4 (PDE4) act as proinflammatory enzymes via degradation of cAMP, whereas PDE4 inhibitors play an anti-inflammatory role in vitro and in vivo. In particular, apremilast has been recently approved for the treatment of psoriasis and p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7f0d3c61e967bcb9048de6280af0320