Zobrazeno 1 - 10
of 263
pro vyhledávání: '"Gerald Hoefler"'
Autor:
Joshua Adekunle Babalola, Anika Stracke, Tina Loeffler, Irene Schilcher, Spyridon Sideromenos, Stefanie Flunkert, Joerg Neddens, Ake Lignell, Manuela Prokesch, Ute Panzenboeck, Herbert Strobl, Jelena Tadic, Gerd Leitinger, Achim Lass, Birgit Hutter-Paier, Gerald Hoefler
Publikováno v:
Molecular Metabolism, Vol 86, Iss , Pp 101972- (2024)
Externí odkaz:
https://doaj.org/article/d463c6ae0e50498bb0f6926bfae42908
Autor:
Sophia E. Chrysostomou, Sandra Eder, Isabella Pototschnig, Anna‐Lena Mayer, Martina Derler, Marion Mussbacher, Silvia Schauer, Dongxu Zhang, Dongmei Yan, Gennie Liu, Gerald Hoefler, Thomas Weichhart, Paul W. Vesely, Lingbing Zhang, Martina Schweiger
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 15, Iss 2, Pp 562-574 (2024)
Abstract Background Cancer‐associated cachexia (CAC) is a debilitating syndrome associated with poor quality of life and reduced life expectancy of cancer patients. CAC is characterized by unintended body weight reduction due to muscle and adipose
Externí odkaz:
https://doaj.org/article/900272734f5246308cda047cdd899863
Autor:
Joshua Adekunle Babalola, Anika Stracke, Tina Loeffler, Irene Schilcher, Spyridon Sideromenos, Stefanie Flunkert, Joerg Neddens, Ake Lignell, Manuela Prokesch, Ute Pazenboeck, Herbert Strobl, Jelena Tadic, Gerd Leitinger, Achim Lass, Birgit Hutter-Paier, Gerald Hoefler
Publikováno v:
Molecular Metabolism, Vol 85, Iss , Pp 101959- (2024)
Objectives: Aggregation and misfolding of amyloid beta (Aβ) and tau proteins, suggested to arise from post-translational modification processes, are thought to be the main cause of Alzheimer's disease (AD). Additionally, a plethora of evidence exist
Externí odkaz:
https://doaj.org/article/adc5cdc60dae4aeea2d8de4c6bfa0ca8
Autor:
Melina Amor, Valentina Bianco, Martin Buerger, Margarete Lechleitner, Nemanja Vujić, Anja Dobrijević, Alena Akhmetshina, Anita Pirchheim, Birgit Schwarz, Ariane R. Pessentheiner, Franziska Baumgartner, Katharina Rampitsch, Silvia Schauer, Iva Klobučar, Vesna Degoricija, Gudrun Pregartner, Daniel Kummer, Monika Svecla, Gerhard Sommer, Dagmar Kolb, Gerhard A. Holzapfel, Gerald Hoefler, Saša Frank, Giuseppe Danilo Norata, Dagmar Kratky
Publikováno v:
Cardiovascular Diabetology, Vol 22, Iss 1, Pp 1-18 (2023)
Abstract Background Matrix metalloproteinase 12 (MMP12) is a macrophage-secreted protein that is massively upregulated as a pro-inflammatory factor in metabolic and vascular tissues of mice and humans suffering from cardiometabolic diseases (CMDs). H
Externí odkaz:
https://doaj.org/article/90391e7f6b60445e9f1c67e516663e8f
Autor:
Isabella Pototschnig, Ursula Feiler, Clemens Diwoky, Paul W. Vesely, Thomas Rauchenwald, Margret Paar, Latifa Bakiri, Laura Pajed, Peter Hofer, Karl Kashofer, Nyamdelger Sukhbaatar, Gabriele Schoiswohl, Thomas Weichhart, Gerald Hoefler, Christoph Bock, Martin Pichler, Erwin F. Wagner, Rudolf Zechner, Martina Schweiger
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 14, Iss 1, Pp 93-107 (2023)
Abstract Background Cancer‐associated cachexia (CAC) is a wasting syndrome drastically reducing efficacy of chemotherapy and life expectancy of patients. CAC affects up to 80% of cancer patients, yet the mechanisms underlying the disease are not we
Externí odkaz:
https://doaj.org/article/562eec85d9b4414fbcf6d13bb3bc9bf1
Autor:
Sara M. Jørgensen, Lasse G. Lorentzen, Astrid Hammer, Gerald Hoefler, Ernst Malle, Christine Y. Chuang, Michael J. Davies
Publikováno v:
Redox Biology, Vol 64, Iss , Pp 102794- (2023)
Continued oxidant production during chronic inflammation generates host tissue damage, with this being associated with pathologies including atherosclerosis. Atherosclerotic plaques contain modified proteins that may contribute to disease development
Externí odkaz:
https://doaj.org/article/58605b2a4b2c4a1dab2a2bac6665414b
Autor:
Valentina Bianco, Melanie Korbelius, Nemanja Vujic, Alena Akhmetshina, Melina Amor, Dagmar Kolb, Anita Pirchheim, Ivan Bradic, Katharina B. Kuentzel, Martin Buerger, Silvia Schauer, Huyen T.T. Phan, Dominik Bulfon, Gerald Hoefler, Robert Zimmermann, Dagmar Kratky
Publikováno v:
Molecular Metabolism, Vol 73, Iss , Pp 101737- (2023)
Objective: To date, the only enzyme known to be responsible for the hydrolysis of cholesteryl esters and triacylglycerols in the lysosome at acidic pH is lysosomal acid lipase (LAL). Lipid malabsorption in the small intestine (SI), accompanied by mac
Externí odkaz:
https://doaj.org/article/56fe92f78f8e4d238b80e8bd6cd05e8b
Autor:
Lisa Pöltl, Maksym Kitsera, Sandra Raffl, Stefan Schild, Amar Cosic, Sabine Kienesberger, Katrin Unterhauser, Georg Raber, Christian Lembacher-Fadum, Rolf Breinbauer, Gregor Gorkiewicz, Carlos Sebastian, Gerald Hoefler, Ellen L. Zechner
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112199- (2023)
Summary: The DNA-alkylating metabolite tilimycin is a microbial genotoxin. Intestinal accumulation of tilimycin in individuals carrying til+ Klebsiella spp. causes apoptotic erosion of the epithelium and colitis. Renewal of the intestinal lining and
Externí odkaz:
https://doaj.org/article/be2aa7e0300d443782126a41699edb73
Autor:
Gunter Almer, Peter Opriessnig, Heimo Wolinski, Gerhard Sommer, Clemens Diwoky, Margarete Lechleitner, Dagmar Kolb, Vladimir Bubalo, Markus S. Brunner, Andreas N. Schwarz, Gerd Leitinger, Gabriele Schoiswohl, Gunther Marsche, Tobias Niedrist, Silvia Schauer, Wolfgang Oswald, Andrea Groselj-Strele, Margret Paar, Gerhard Cvirn, Gerald Hoefler, Gerald N. Rechberger, Markus Herrmann, Saša Frank, Gerhard A. Holzapfel, Dagmar Kratky, Harald Mangge, Gerd Hörl, Oksana Tehlivets
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 154, Iss , Pp 113640- (2022)
Atherosclerosis, the leading cause of cardiovascular disease responsible for the majority of deaths worldwide, cannot be sufficiently explained by established risk factors, including hypercholesterolemia. Elevated plasma homocysteine is an independen
Externí odkaz:
https://doaj.org/article/061cafcb1023474998e33bea7d031060
Autor:
Georg Richtig, Melanie Kienzl, Sonja Rittchen, David Roula, Jürgen Eberle, Zina Sarif, Martin Pichler, Gerald Hoefler, Akos Heinemann
Publikováno v:
Biology, Vol 12, Iss 5, p 706 (2023)
Background: Cannabinoids are mainly used for recreational purposes, but also made their way into oncology, since these substances can be taken to increase appetite in tumour cachexia. Since there are some hints in the literature that cannabinoids mig
Externí odkaz:
https://doaj.org/article/42ac9a3f78e5456fae3933322e886bf9