Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Gerald H. Thomsen"'
Publikováno v:
Open Biology, Vol 2, Iss 4 (2012)
Transforming growth factor β superfamily members signal through Smad transcription factors. Bone morphogenetic proteins (BMPs) act via Smads 1, 5 and 8 and TGF-βs signal through Smads 2 and 3. The endocytic adaptor protein Eps15R, or ‘epidermal g
Externí odkaz:
https://doaj.org/article/8d205241567b43e38f72bd1c039a9ea4
Autor:
Patricia Bossert, Gerald H. Thomsen
Publikováno v:
Journal of Visualized Experiments.
Cnidarians, and specifically Hydra, were the first animals shown to regenerate damaged or severed structures, and indeed such studies arguably launched modern biological inquiry through the work of Trembley more than 250 years ago. Presently the stud
Autor:
Gerald H. Thomsen, Yasuno Iwasaki
Publikováno v:
Development. 141:3740-3751
Alternative splicing of pre-mRNAs is an important means of regulating developmental processes, yet the molecular mechanisms governing alternative splicing in embryonic contexts are just beginning to emerge. Polyglutamine-binding protein 1 (PQBP1) is
Publikováno v:
Developmental Biology. 392(2):358-367
Smad proteins convey canonical intracellular signals for activated receptors in the TGFβ superfamily, but the activity of Smads and their impact on target genes are further regulated by a wide variety of cofactors and partner proteins. We have ident
Autor:
Jamina Oomen-Hajagos, Gerald H. Thomsen, Takuya Nakayama, Marilyn Fisher, Margaret B. Fish, Robert M. Grainger
Publikováno v:
genesis. 51:835-843
We have assessed the efficacy of the recently developed CRISPR/Cas (clustered regularly interspaced short palindromic repeats/CRISPR-associated) system for genome modification in the amphibian Xenopus tropicalis. As a model experiment, targeted mutat
Publikováno v:
Developmental Dynamics. 242:1320-1331
Background: As the sea anemone Nematostella vectensis emerges as a model for studying regeneration, new tools will be needed to assess its regenerative processes and describe perturbations resulting from experimental investigation. Chief among these
Autor:
Arif Kirmizitas, Gerald H. Thomsen, Jonathan M. Wyrick, Yasuno Iwasaki, William Q. Gillis, Dong Hyuk Ki
Publikováno v:
Cell Communication and Signaling : CCS
Background Canonical Wnt signals, transduced by stabilized β-catenin, play similar roles across animals in maintaining stem cell pluripotency, regulating cell differentiation, and instructing normal embryonic development. Dysregulated Wnt/β-catenin
Publikováno v:
Developmental Biology
T-box family transcription factors play many roles in Metazoan development. Here we characterise Tbx6r, a unique Tbx6 paralogue isolated from the amphibian Xenopus. The evolution and developmental integration of this divergent T-box gene within the v
Publikováno v:
Current Biology. 16:499-505
Summary Cnidarians (corals, sea anemones, hydroids, and jellyfish) are a basal taxon closely related to bilaterally symmetrical animals [1–3] and have been characterized as diploblastic and as radially symmetrical around their longitudinal axis. We
Autor:
Abiodun A. Ogunjimi, Barish Ozdamar, Gerald H. Thomsen, Jeffrey L. Wrana, Yue Zhang, Hong-Rui Wang, Evguenia Alexandrova
Publikováno v:
Science. 302:1775-1779
The Rho family of small guanosine triphosphatases regulates actin cytoskeleton dynamics that underlie cellular functions such as cell shape changes, migration, and polarity. We found that Smurf1, a HECT domain E3 ubiquitin ligase, regulated cell pola