Výsledky vyhledávání - "Gerald H. Hankes"

β1-Adrenoceptor blockade mitigates excessive norepinephrine release into cardiac interstitium in mitral regurgitation in dog

Autor: Louis J. Dell'Italia, René Cardinal, Jose A. Tallaj, Patricia Rynders, Ray Dillon, Gerald H. Hankes, Jeffrey L. Ardell, Donald B. Hoover, J. Andrew Armour, Inmaculada Aban, Merrilee Holland, Chih-Chang Wei, Ahsan Husain

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 291:H147-H151

Mitral regurgitation (MR) is associated with increased neuronal release of norepinephrine (NE) and epinephrine (EP) into myocardial interstitial fluid (ISF) that may be necessary in sustaining left ventricular (LV) function via activation of cardiomy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34c936d5139c8d6a67bb9598eda097e0
https://doi.org/10.1152/ajpheart.00951.2005

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ACE inhibitors in HF restore canine pulmonary endothelial function and ANG II vasoconstriction

Autor: Gerald H. Hankes, A. Raymond Dillon, Louis J. Dell'Italia, R. Earl Cartee, Jun Dai, Gerald M. Pohost, Ingrid M. Straeter-Knowlen, David D. Ku

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 277:H1924-H1930

Chronic mitral regurgitation (MR) in dogs results in pulmonary congestion and increased cardiac angiotensin-converting enzyme (ACE) activity and angiotensin (ANG) II levels. ACE could contribute to altered pulmonary vasomotion in heart failure, and A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0303945b7eb24fd848a45e874b9e2258
https://doi.org/10.1152/ajpheart.1999.277.5.h1924

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Compartmentalization of angiotensin II generation in the dog heart. Evidence for independent mechanisms in intravascular and interstitial spaces

Autor: Suzanne Oparil, Louis J. Dell'Italia, Chih Chang Wei, Gilbert R. Hageman, Ronald Palmer, Qing C. Meng, Joan Durand, Gerald H. Hankes, Eduardo Balcells

Publikováno v: Journal of Clinical Investigation. 100:253-258

Angiotensin-converting enzyme inhibitors have beneficial effects that are presumably mediated by decreased angiotensin II (ANG II) production. In this study, we measure for the first time ANG I and ANG II levels in the interstitial fluid (ISF) space

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d49109a1e4b8bee6d6a4ee384541216b
https://doi.org/10.1172/jci119529

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Beta1-adrenergic receptor blockade attenuates angiotensin II-mediated catecholamine release into the cardiac interstitium in mitral regurgitation

Autor: Louis J. Dell'Italia, Merrilee Holland, Pamela A. Lucchesi, J. Andrew Armour, Gerald H. Hankes, A. Ray Dillon, Chih-Chang Wei, Jose A. Tallaj, Patricia Rynders, Jeffrey L. Ardell

Publikováno v: Circulation. 108(2)

Background— This study tested the hypothesis that β 1 -adrenoreceptor blockade modulates the angiotensin II (Ang II)–evoked neural release of norepinephrine (NE) and epinephrine (Epi) into the cardiac interstitial fluid (ISF) space in experiment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3c66c784c65f2f697a8459bc618584e
https://pubmed.ncbi.nlm.nih.gov/12847066

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Cardiac mast cell- and chymase-mediated matrix metalloproteinase activity and left ventricular remodeling in mitral regurgitation in the dog

Autor: A. Ray Dillon, Gerald H. Hankes, James A. Stewart, Patricia Rynders, Chih Chang Wei, Joseph S. Janicki, Gregory L. Brower, Pamela A. Lucchesi, Louis J. Dell'Italia

Publikováno v: Journal of molecular and cellular cardiology. 35(3)

The present study tested the hypothesis that cardiac mast cells and chymase are associated with matrix metalloproteinase (MMP) activation and extracellular matrix (ECM) degradation in the evolution of left ventricular (LV) chamber remodeling secondar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eca7668461fcc74802cd903d1a282ad
https://pubmed.ncbi.nlm.nih.gov/12676546

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Angiotensin II receptor blockade does not improve left ventricular function and remodeling in subacute mitral regurgitation in the dog

Autor: Chih-Chang Wei, Gilbert J. Perry, Patricia Rynders, Francis G. Spinale, S.Ray Dillon, Rupak Mukherjee, Louis J. Dell’Italia, Gerald H. Hankes

Publikováno v: Journal of the American College of Cardiology. 39(8)

ObjectivesWe hypothesized that angiotensin II type-1 (AT1) receptor blocker (AT1RB) would prevent adverse left ventricular (LV) remodeling and LV dysfunction when started at the outset of mitral regurgitation (MR).BackgroundLittle is known regarding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5051ced2a18bc16fa6b978a58c563ecd
https://pubmed.ncbi.nlm.nih.gov/11955859

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Differential expression of angiotensin-converting enzyme and chymase in dogs with chronic mitral regurgitation

Autor: Xuefeng Su, Naburo Machida, Suzanne Oparil, Ray Dillon, Chih-Chang Wei, Sanford P. Bishop, Gerald H. Hankes, Louis J. Dell»Italia

Publikováno v: Journal of molecular and cellular cardiology. 31(5)

The current study tested the hypothesis that angiotensin-converting enzyme (ACE) and chymase expression are subject to different regulatory processes in the heart, as well as the lungs and kidneys and, as a result, have an important effect on the eff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ae442750fa5d3dd49062f67a0b1f271
https://pubmed.ncbi.nlm.nih.gov/10339353

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Evidence for angiotensin-converting enzyme- and chymase-mediated angiotensin II formation in the interstitial fluid space of the dog heart in vivo

Autor: Suzanne Oparil, Gerald H. Hankes, Chih-Chang Wei, Joan Durand, Louis J. Dell'Italia, Qing C. Meng, Diane M. Farrell, Wayne E. Bradley, Gilbert R. Hageman, Ronald Palmer

Publikováno v: Circulation. 99(19)

Background —We have previously demonstrated that angiotensin II (Ang II) levels in the interstitial fluid (ISF) space of the heart are higher than in the blood plasma and do not change after systemic infusion of Ang I. In this study, we assess the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32a49a7ac7f74570ca4a96d27d19c80b
https://pubmed.ncbi.nlm.nih.gov/10330392

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Survival in dogs with nasal adenocarcinoma: 64 cases (1981-1995)

Autor: Ralph A. Henderson, Jeff W. Tyler, Natalie Royer, Carolyn J. Henry, William G. Brewer, Gerald H. Hankes, William R. Brawner

Publikováno v: Journal of veterinary internal medicine. 12(6)

Case records of 64 dogs with nasal adenocarcinoma were reviewed. The effects of age, gender, tumor stage, presence of metastatic lesions, and treatment method on survival time were examined. Surgery groups included rhinotomy (n = 9), transnasal curet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d09956cd1696a8a3d80baefcce24ae5
https://pubmed.ncbi.nlm.nih.gov/9857336

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965-52 Relationship Between Heart Chymase and ACE Activity in Dogs with Volume Overload Hypertrophy and Increased Cardiac Angiotensin Peptide Levels

Autor: Oing C. Meng, T. S. Elton, Ray Dillon, Gerald H. Hankes, Louis J. Dell'ltalia, Sanford P. Bishop, Eduardo Balcells, Suzanne Oparil, Ingrid Straeter-Knowlan

Publikováno v: Journal of the American College of Cardiology. 25:223A

We have previously reported increased intracardiac angiotensin II (ANG II) levels in a dog model of volume overload hypertrophy produced by percutaneous chordal rupture of the mitral valve. Whether the increase in ANG II is mediated by angiotensin co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7b3efeddd20927b3e5ac86cb2cb27e6
https://doi.org/10.1016/0735-1097(95)92385-i

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