Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Gerald G. Long"'
Autor:
Michael S. Thibodeau, Renee R. Hukkanen, Wendy G. Halpern, John Eighmy, Emily K. Meseck, James D Fikes, Daniel J. Patrick, Gerald G. Long, Sabine Francke, Charles E. Wood, Kenneth A Schafer
Publikováno v:
Toxicologic pathology. 46(3)
The severity grade is an important component of a histopathologic diagnosis in a nonclinical toxicity study that helps distinguish treatment-related effects from background findings and aids in determining adverse dose levels during hazard characteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8678115dcffca68b4860340702565ef8
https://pubmed.ncbi.nlm.nih.gov/29529947
https://pubmed.ncbi.nlm.nih.gov/29529947
Autor:
Thomas J. Rosol, Thomas Ryan, Jamie L. Blackbourne, Steven D. Sorden, John L. Vahle, Ricardo Quander, John A. Wijsman, Richard LaRock, Jennifer A. Martin, Richard A. Byrd, Thomas Pienkowski, Holly W. Smith, Gerald G. Long
Publikováno v:
Endocrinology. 156:2417-2428
The tumorigenic potential of dulaglutide was evaluated in rats and transgenic mice. Rats were injected sc twice weekly for 93 weeks with dulaglutide 0, 0.05, 0.5, 1.5, or 5 mg/kg corresponding to 0, 0.5, 7, 20, and 58 times, respectively, the maximum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf05a45d550322893380cb5ee957415f
https://doi.org/10.1210/en.2014-1722
https://doi.org/10.1210/en.2014-1722
Autor:
Richard Haworth, Michael Mirsky, Gerald G. Long, Justin D. Vidal, Ute Bach, Anke Heuser, Ronald A. Herbert, Karen Regan, Midori Yoshida, F. Russell Westwood, Johannes H. Harleman, George L. Foley, Darlene Dixon, Eric Van Esch, Roger Alison, Karyn Colman
Publikováno v:
Journal of Toxicologic Pathology
The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) Project (www.toxpath.org/inhand.asp) is a joint initiative of the Societies of Toxicological Pathology from Europe (ESTP), Great Britain (BS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14316589e64325c4d1fddaf85284ec7f
http://europepmc.org/articles/PMC4253081
http://europepmc.org/articles/PMC4253081
Autor:
Gerald G. Long, Bassem Attalla, Sabile Trimm, Jacquelin Jolette, Susan Y. Smith, Nacera Mellal, Aurore Varela, Gary Hattersley, Michael S. Ominsky
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 86
Prolonged treatment with human parathyroid hormone (hPTH) in rats results in development of bone tumors, though this finding has not been supported by clinical experience. The PTH type 1 receptor agonist abaloparatide, selected for its bone anabolic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0630eac7a934c44881189c150aa29a0c
https://pubmed.ncbi.nlm.nih.gov/28389324
https://pubmed.ncbi.nlm.nih.gov/28389324
Publikováno v:
Toxicologic Pathology. 37:741-753
The carcinogenic potential of naveglitazar, a γ-dominant peroxisome proliferator-activated receptor (PPAR) α/γ dual agonist, was evaluated in a two-year study in F344 rats (0, 0.3, 1.0, or 3.0 mg/kg, males; 0, 0.1, 0.3, or 1.0 mg/kg, females). Inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3583d61bb806fcbf755e2998558be0f
https://doi.org/10.1177/0192623309343775
https://doi.org/10.1177/0192623309343775
Autor:
Jay I. Goodman, Richard D. Storer, Peter Kasper, Douglas A. Keller, Abigail Jacobs, Ronald J. Gerson, Gerald G. Long, John E. French, Tohru Inoue, Amy L. Lavin, James S. MacDonald, Bruce McCullough, Frank D. Sistare, Jan Willem van der Laan
Publikováno v:
Toxicological Sciences. 77:188-194
The Alternatives to Carcinogenicity Testing Committee of the International Life Sciences Institute (ILSI) Health and Environmental Sciences Institute (HESI) conducted a large-scale, multinational collaborative research program to evaluate several gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1d01af48b5a8bb8b6dbe956d70f54f7
https://doi.org/10.1093/toxsci/kfh037
https://doi.org/10.1093/toxsci/kfh037
Autor:
Paul C Francis, Masahiko Sato, Yanfei Linda Ma, John L. Vahle, Michael Westmore, Jeffery A. Engelhardt, Gerald G. Long, James B. Nold, Jamie K. Young
Publikováno v:
Toxicologic Pathology. 30:312-321
Fischer 344 rats (60/sex/group) were given daily subcutaneou s injections of recombinant human parathyroi d hormone (PTH)(1-34) for 2 years at doses of 0, 5, 30, or 75 μg/kg. Treatment caused substantial increases in bone mass consistent with the kn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f32ca5cc9fc10efebbfaa1f6a9f9fcb
https://doi.org/10.1080/01926230252929882
https://doi.org/10.1080/01926230252929882
Publikováno v:
Toxicologic Pathology. 30:147-156
ILSI-HESI sponsored an international consortium for the evaluation of alternative models, including the Trp53+ /- mouse, for use in short-term carcinogenicity testing of pharmaceuticals. Products of the ILSI evaluation included guidance for protocol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f4b821b79f119c1de48fa67d492d920
https://doi.org/10.1080/01926230252824860
https://doi.org/10.1080/01926230252824860
Publikováno v:
Toxicologic Pathology. 30:93-96
A pathology report is written to convey information concerning the pathologic findings in a study. This type of report must be complete, accurate and communicate the relative importance of various findings in a study. The overall quality of the repor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e99a6beccfd0cb5542e4710a006e649f
https://doi.org/10.1080/01926230252824761
https://doi.org/10.1080/01926230252824761
Autor:
Gerald G. Long, Ilene R. Cohen, Paul C Francis, Millie L Sims, Michelle R. Robbins, Mark Lakshmanan
Publikováno v:
Reproductive Toxicology. 14:37-44
Raloxifene is a selective estrogen receptor modulator that has estrogen agonist effects on bone and serum lipids and estrogen antagonist effects on breast and uterine tissues. This study assessed the effects of raloxifene hydrochloride (HCl) treatmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c1b06fa3e832ed86f80a2e0bdbd70d9
https://doi.org/10.1016/s0890-6238(99)00065-9
https://doi.org/10.1016/s0890-6238(99)00065-9