Výsledky vyhledávání - "Gerald F. Audette"

Akademický článek

Solution characterization of the dynamic conjugative entry exclusion protein TraG

Autor: Nicholas Bragagnolo, Gerald F. Audette

Publikováno v: Structural Dynamics, Vol 9, Iss 6, Pp 064702-064702-16 (2022)

The R100 plasmid and the secretion system it encodes are representative of F-like conjugative type IV secretion systems for the transmission of mobile DNA elements in gram-negative bacteria, serving as a major contributor to the spread of antibiotic

Externí odkaz: https://doaj.org/article/d4fcc3ae6f6d4bad90055e8704f2c797

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Akademický článek

Structural and functional consequences of the STAT5BN642H driver mutation

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)

Hyper-activated STAT5B and its disease-causing variants are of interest as cancer drug targets. Here the authors combine cell based studies, X-ray crystallography, biophysical experiments and MD simulations to structurally and functionally characteri

Externí odkaz: https://doaj.org/article/f8b672c48f8f4b91911646f53ce84f0b

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Akademický článek

Crystal structures of the synthetic intermediate 3-[(6-chloro-7H-purin-7-yl)methyl]cyclobutan-1-one, and of two oxetanocin derivatives: 3-[(6-chloro-8,9-dihydro-7H-purin-7-yl)methyl]cyclobutan-1-ol and 3-[(6-chloro-9H-purin-9-yl)methyl]cyclobutan-1-ol

Autor: Ayat Yaseen, Muhammad Murtaza Hassan, Edward Lee-Ruff, Gerald F. Audette

Publikováno v: Acta Crystallographica Section E: Crystallographic Communications, Vol 75, Iss 6, Pp 732-737 (2019)

The crystal structures of an intermediate, C10H9ClN4O, 3-[(6-chloro-7H-purin-7-yl)methyl]cyclobutan-1-one (I), and two N-7 and N-9 regioisomeric oxetanocin nucleoside analogs, C10H13ClN4O, 3-[(6-chloro-8,9-dihydro-7H-purin-7-yl)methyl]cyclobutan-1-ol

Externí odkaz: https://doaj.org/article/5a7811ee3ca94a4c9da7851a2c79aef9

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Akademický článek

Biomedical Applications of Biomolecules Isolated from Methanotrophic Bacteria in Wastewater Treatment Systems

Autor: Rana Salem, Ahmed ElDyasti, Gerald F. Audette

Publikováno v: Biomolecules, Vol 11, Iss 8, p 1217 (2021)

Wastewater treatment plants and other remediation facilities serve important roles, both in public health, but also as dynamic research platforms for acquiring useful resources and biomolecules for various applications. An example of this is methanot

Externí odkaz: https://doaj.org/article/abe24bc461454b93bae38a7df4c42230

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Akademický článek

Screening for Methane Utilizing Mixed Communities with High Polyhydroxybutyrate (PHB) Production Capacity Using Different Design Approaches

Autor: Rana Salem, Moomen Soliman, Ahmed Fergala, Gerald F. Audette, Ahmed ElDyasti

Publikováno v: Polymers, Vol 13, Iss 10, p 1579 (2021)

With the adverse environmental ramifications of the use of petroleum-based plastic outweighing the challenges facing the industrialization of bioplastics, polyhydroxyalkanoate (PHA) biopolymer has gained broad interest in recent years. Thus, an effic

Externí odkaz: https://doaj.org/article/8451dc299ecc474e813da7b09ec3f94b

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Akademický článek

Protein Dynamics in F-like Bacterial Conjugation

Autor: Nicholas Bragagnolo, Christina Rodriguez, Naveed Samari-Kermani, Alice Fours, Mahboubeh Korouzhdehi, Rachel Lysenko, Gerald F. Audette

Publikováno v: Biomedicines, Vol 8, Iss 9, p 362 (2020)

Efficient in silico development of novel antibiotics requires high-resolution, dynamic models of drug targets. As conjugation is considered the prominent contributor to the spread of antibiotic resistance genes, targeted drug design to disrupt vital

Externí odkaz: https://doaj.org/article/9fa05563373a428689027be0a9c1ab17

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Akademický článek

Protein Nanotubes: From Bionanotech towards Medical Applications

Autor: Gerald F. Audette, Ayat Yaseen, Nicholas Bragagnolo, Raj Bawa

Publikováno v: Biomedicines, Vol 7, Iss 2, p 46 (2019)

Nanobiotechnology involves the study of structures found in nature to construct nanodevices for biological and medical applications with the ultimate goal of commercialization. Within a cell most biochemical processes are driven by proteins and assoc

Externí odkaz: https://doaj.org/article/921eb0fdea5a425e9979b8ee42afa7ee

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Akademický článek

Dimerization of the type IV pilin from Pseudomonas aeruginosa strain K122-4 results in increased helix stability as measured by time-resolved hydrogen-deuterium exchange

Autor: Cristina Lento, Derek J. Wilson, Gerald F. Audette

Publikováno v: Structural Dynamics, Vol 3, Iss 1, Pp 012001-012001-13 (2016)

Truncated pilin monomers from Pseudomonas aeruginosa strain K122-4 (ΔK122) have been shown to enter a monomer-dimer equilibrium in solution prior to oligomerization into protein nanotubes. Here, we examine the structural changes occurring between th

Externí odkaz: https://doaj.org/article/a452c8b6b815406dbccf600c4913e94a

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