Zobrazeno 1 - 10
of 143
pro vyhledávání: '"Gerald F Joyce"'
Publikováno v:
eLife, Vol 10 (2021)
An RNA polymerase ribozyme that has been the subject of extensive directed evolution efforts has attained the ability to synthesize complex functional RNAs, including a full-length copy of its own evolutionary ancestor. During the course of evolution
Externí odkaz:
https://doaj.org/article/712107c19f934467961e7093da97caee
Autor:
Biswajit Samanta, Gerald F Joyce
Publikováno v:
eLife, Vol 6 (2017)
A highly evolved RNA polymerase ribozyme was found to also be capable of functioning as a reverse transcriptase, an activity that has never been demonstrated before for RNA. This activity is thought to have been crucial for the transition from RNA to
Externí odkaz:
https://doaj.org/article/fa1e044611824506b43812b00503a257
Autor:
Gerald F Joyce
Publikováno v:
PLoS Biology, Vol 10, Iss 5, p e1001323 (2012)
All known examples of life belong to the same biology, but there is increasing enthusiasm among astronomers, astrobiologists, and synthetic biologists that other forms of life may soon be discovered or synthesized. This enthusiasm should be tempered
Externí odkaz:
https://doaj.org/article/bc1ab2fe0cec478d8317e2dd06826016
Autor:
Brian M Paegel, Gerald F Joyce
Publikováno v:
PLoS Biology, Vol 6, Iss 4, p e85 (2008)
Computer control of Darwinian evolution has been demonstrated by propagating a population of RNA enzymes in a microfluidic device. The RNA population was challenged to catalyze the ligation of an oligonucleotide substrate under conditions of progress
Externí odkaz:
https://doaj.org/article/62f02f3bee20464b9dd18a50efd1273c
Autor:
Ankana Kakoti, Gerald F. Joyce
Publikováno v:
Biochemistry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f434d124a406f655e7c0d4154db0a96b
https://doi.org/10.1021/acs.biochem.3c00091
https://doi.org/10.1021/acs.biochem.3c00091
Autor:
Grant A L Bare, Gerald F. Joyce
Publikováno v:
Journal of the American Chemical Society. 143:19160-19166
Informational macromolecules in biology are composed of subunits of a single handedness, d-nucleotides in nucleic acids and l-amino acids in proteins. Although this chiral uniformity may be expedient, it is not a chemical necessity, as demonstrated b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30aaee8b751c9e934bcd0a30a53990a6
https://doi.org/10.1021/jacs.1c09233
https://doi.org/10.1021/jacs.1c09233
Autor:
Elena Menichelli, Bianca J. Lam, Yu Wang, Vivian S. Wang, Jennifer Shaffer, Katrina F. Tjhung, Badry Bursulaya, Truc Ngoc Nguyen, Todd Vo, Phillip B Alper, Christopher S McAllister, David H. Jones, Glen Spraggon, Pierre-Yves Michellys, John Joslin, Gerald F. Joyce, Jeff Rogers
Publikováno v:
Proceedings of the National Academy of Sciences. 119
There is growing interest in therapeutic intervention that targets disease-relevant RNAs using small molecules. While there have been some successes in RNA-targeted small-molecule discovery, a deeper understanding of structure–activity relationship
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81b63539b3423ca34c26d9030ee5bf0b
https://doi.org/10.1073/pnas.2213117119
https://doi.org/10.1073/pnas.2213117119
Publikováno v:
eLife, Vol 10 (2021)
An RNA polymerase ribozyme that has been the subject of extensive directed evolution efforts has attained the ability to synthesize complex functional RNAs, including a full-length copy of its own evolutionary ancestor. During the course of evolution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b28380fd880e316760d3bab52dd9493
https://doi.org/10.1101/2021.06.22.449496
https://doi.org/10.1101/2021.06.22.449496
