Výsledky vyhledávání - "Gerald E. Stokker"

2-(Aminomethyl)phenols, a new class of saluretic agents. 4. Effects of oxygen and/or nitrogen substitution

Autor: H. F. Russo, A. A. Deana, Smith Robert L, Cragoe Edward J, Gerald E. Stokker, Everett M. Schultz, L. S. Watson, S J deSolms, J. E. Baer

Publikováno v: Journal of Medicinal Chemistry. 25:735-742

A series of oxygen and/or nitrogen substituted 2-(aminomethyl)phenols was synthesized and tested orally in rats for saluretic and diuretic effects. Intravenous dog data are included as supplementary material to demonstrate diuretic responses, or lack

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::662dd11ab28bfde25e2857bd992846f0
https://doi.org/10.1021/jm00348a024

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(Acylaryloxy)acetic acid diuretics. 5. [(2-Alkyl- and 2,2-disubstituted-1,3-dioxo-5-indanyl)oxy]acetic acids

Autor: Cragoe Edward J, S J deSolms, Gerald E. Stokker, Otto W. Woltersdorf

Publikováno v: Journal of Medicinal Chemistry. 27:840-845

Investigation of the chemistry of the potent uricosuric diuretic indacrinone (MK-196) prompted the synthesis of a series of 3-oxo derivatives, i.e., the indan-1,3-diones. In general, both pharmacological parameters (uricosuria and diuresis) were sign

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::069b37b56078e8a9db37e591b6a0c0a0
https://doi.org/10.1021/jm00373a005

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2-(Aminomethyl)phenols, a new class of saluretic agents. 6. Effects of N,O-spiroannulation and subsequent quarternization

Autor: Cragoe Edward J, Gerald E. Stokker, Charles S. Sweet, H. F. Russo, L. S. Watson, Smith Robert L, Ludden Ct, Everett M. Schultz

Publikováno v: Journal of Medicinal Chemistry. 26:585-590

The synthesis of a number of 3,4-dihydrospiro-2H-1,3-benzoxazines and their corresponding benzoxazinium salts are reported. The saluretic effects displayed by these N,O-spiroannulated 2-(aminomethyl)phenols appear to be, in part, inversely related to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::135f17320f0e2a9b2c35b2e69b19b9bb
https://doi.org/10.1021/jm00358a024

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2-(Aminomethyl)phenols, a new class of saluretic agents. 5. Fused-ring analogs

Autor: L. S. Watson, A. A. Deana, H. F. Russo, Smith Robert L, Gerald E. Stokker, Cragoe Edward J, Everett M. Schultz

Publikováno v: Journal of Medicinal Chemistry. 26:580-585

A number of bicyclic ring-fused analogues of 2-(aminomethyl)phenol were synthesized and tested orally in rats and intravenously in dogs for saluretic and diuretic effects. Of the 15 alicylic, aromatic, and heterocyclic ring-fused compounds tested, on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce3c440c9041751946d4642c7c09a0e6
https://doi.org/10.1021/jm00358a023

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Palladium catalyzed stereospecific Michael arylation of 6-alkyl-5,6-dihydro-2H-pyran-2-ones

Autor: Gerald E. Stokker

Publikováno v: Tetrahedron Letters. 28:3179-3182

The Michael arylation of 6-[2-(2,4-dichlorophenyl)ethyl]-5,6-dihydro-2H-pyran-2-one with aryl iodides in the presence of Pd [0] resulted in stereospecific addition followed by a hydrogen abstraction from triethylamine.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cef882ad81228b282d40993d39ef7bf9
https://doi.org/10.1016/s0040-4039(00)95465-0

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2-(Aminomethyl)phenols, a new class of saluretic agents. 2. Synthesis and pharmacological properties of the 5-aza isostere of 2-(aminomethyl)-4-(1,1-dimethylethyl)-6-iodophenol

Autor: H. F. Russo, Ludden Ct, L. S. Watson, Smith Robert L, Charles S. Sweet, Gerald E. Stokker, Cragoe Edward J

Publikováno v: Journal of Medicinal Chemistry. 24:115-117

The synthesis and biological evaluation of 4-(aminomethyl)-6-(1,1-dimethylethyl)-2-iodo-3-pyridinol dihydrochloride (7b) are described. Compound 7b proved to be highly active as a saluretic diuretic in both rats and dogs.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::118703a3faae6aff926ded5987df0d66
https://doi.org/10.1021/jm00133a024

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Agents for the treatment of brain edema. 2. [(2,3,9,9a-Tetrahydro-3-oxo-9a-substituted-1H-fluoren-7-yl)oxy]+ ++alkanoi c acids and some of their analogues

Autor: Gerald E. Stokker, Harold K. Kimelberg, Carl B. Ziegler, Cragoe Edward J, Otto W. Woltersdorf, N. P. Gould, Bourke Rs, Adolph M. Pietruszkiewicz, Yoshiya Sakurai, P. S. Anderson

Publikováno v: Journal of medicinal chemistry. 29(5)

Our initial paper discussed brain edema resulting from traumatic head injury and the need for specific and effective agents to treat the disorder and disclosed a novel approach for the discovery of a drug of this kind. The current study describes the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24f8f7365e7041f4855f4374b10d6e7d
https://pubmed.ncbi.nlm.nih.gov/3701792

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