Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Gerald E. Hunsberger"'
Autor:
Jason A. Miranda, Adrien Rapeaux, Isabelle C. Samper, Carolina Silveira, David R. Wille, Gerald E. Hunsberger, Wesley J. Dopson, Huanfen Yao, Annapurna Karicherla, Daniel J. Chew
Publikováno v:
IEEE Open Journal of Engineering in Medicine and Biology, Vol 5, Pp 59-65 (2024)
Emerging therapies in bioelectronic medicine highlight the need for deeper understanding of electrode material performance in the context of tissue stimulation. Electrochemical properties are characterized on the benchtop, facilitating standardizatio
Externí odkaz:
https://doaj.org/article/e1ff5363f8df4ffd87172bf9dfeadadb
Autor:
Santhosh M. Baby, Faisal Zaidi, Gerald E. Hunsberger, David Sokal, Isha Gupta, Silvia V. Conde, Daniel Chew, Kristen Rall, Robert W. Coatney
Publikováno v:
Experimental Physiology, Vol 108, Iss 2, Pp 280-295 (2023)
Abstract The carotid body chemoreceptors (CBC) play an important role in the adaptive counter‐regulatory response to hypoglycaemia by evoking the CBC‐mediated sympathetic neuronal system to restore normoglycaemia. Ex vivo studies have shown varie
Externí odkaz:
https://doaj.org/article/d532d0dd1b3b4818b89b67f0ba51c881
Autor:
Santhosh M. Baby, Faisal Zaidi, Gerald E. Hunsberger, David Sokal, Isha Gupta, Silvia V. Conde, Daniel Chew, Kristen Rall, Robert W. Coatney
Publikováno v:
Experimental physiologyREFERENCES.
Funding: Silvia V. Conde declares that Galvani Bioelectronics provided funds to support their work associated with Type 2 diabetic project. New Findings: What is the central question of this study? What are the effects of insulin and insulin-induced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::194ecb57b46e1da17e1116602a91fcf2
https://pubmed.ncbi.nlm.nih.gov/36459572
https://pubmed.ncbi.nlm.nih.gov/36459572
Autor:
M. Teresa Pulido-Rios, Mathai Mammen, TaeWeon Lee, James J. Foley, Sharath S. Hegde, Gerald E. Hunsberger, Jeffrey R. Jasper, Mark A. Luttmann, Tod Steinfeld, Yuhua Ji
Publikováno v:
Pharmacology Research & Perspectives
Revefenacin (TD‐4208) is a novel, long‐acting, and lung‐selective muscarinic cholinergic receptor (mAChR) antagonist in development as a nebulized inhalation solution for the treatment of chronic obstructive pulmonary disease (COPD) patients. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f83255eedd981c22148b086bac50df7f
http://europepmc.org/articles/PMC5927803
http://europepmc.org/articles/PMC5927803
Autor:
Ruth J. Mayer, Michael Salmon, Miriam Burman, Donald C. Carpenter, Jakob Busch-Petersen, John Yonchuk, David J. Kilian, James J. Foley, Gerald E. Hunsberger, Ruth Tal-Singer
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 362(2)
CXC chemokine receptor 2 (CXCR2) is a key receptor in the chemotaxis of neutrophils to sites of inflammation. The studies reported here describe the pharmacological characterization of danirixin, a CXCR2 antagonist in the diaryl urea chemical class.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::653c1590be6e82e88b8bc4de3ebcf433
https://pubmed.ncbi.nlm.nih.gov/28611093
https://pubmed.ncbi.nlm.nih.gov/28611093
Autor:
Henry M. Sarau, Sandra Umbrecht, Widdowson Katherine L, Palovich Michael R, Michael Salmon, Haibo Xie, Hongxing Yan, Jakob Busch-Petersen, Mark A. Luttmann, James J. Foley, Brian Peck, Jeremy Dufour, Zehong Wan, Gerald E. Hunsberger, Philip S. Landis, Dramane I. Laine, Alicia M. Bacon, Miriam Burman, Edward F. Webb, Roderick S. Davis, Dulcie B. Schmidt
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:3366-3369
A novel series of N-substituted tropane derivatives was characterized as potent muscarinic acetylcholine receptor antagonists (mAChRs). Kinetic washout studies showed that the N-endosubstituted analog 24 displayed much slower reversibility at mAChRs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b1b7fc6e766a219b970ade89feb8801
https://doi.org/10.1016/j.bmcl.2012.02.015
https://doi.org/10.1016/j.bmcl.2012.02.015
Autor:
John J. Kerrigan, Dulcie B. Schmidt, James J. Foley, Abby J. Sukman, Tia Lewis, Patrick McDevitt, Kathleen T. Gallagher, Kyung O. Johanson, Robert S. Ames, James A. Fornwald, Taylor L. Graham, Matthew C. Burns, Quinn Lu, Xiaoyan Tang, Gerald E. Hunsberger
Publikováno v:
Protein Expression and Purification. 65:251-260
We describe here two strategies to produce biologically active chemokines with authentic N-terminal amino acid residues. The first involves producing the target chemokine with an N-terminal 6×His-SUMO tag in Escherichia coli as inclusion bodies. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::951418dee127686dd1f484c032678731
https://doi.org/10.1016/j.pep.2009.01.017
https://doi.org/10.1016/j.pep.2009.01.017
Autor:
Henry M. Sarau, Feng Wang, Gerald E. Hunsberger, Elizabeth A. Capper-Spudich, Ralph A. Rivero, James J. Foley, Yonghui Wang, Zheng Yang, Laura S. Fisher, Todd L. Graybill, Michael S. McQueney, Jian Jin, Widdowson Katherine L, Zining Wu, Dulcie B. Schmidt, Terence J. Kiesow, Jakob Busch-Petersen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:114-118
A series of N-arylpiperazine camphor sulfonamides was discovered as novel CXCR3 antagonists. The synthesis, structure–activity relationships, and optimization of the initial hit that resulted in the identification of potent and selective CXCR3 anta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff022de9cf3c289d1a821663993332c2
https://doi.org/10.1016/j.bmcl.2008.11.008
https://doi.org/10.1016/j.bmcl.2008.11.008
Autor:
Lisa A. Payne, Nambi V. Aiyar, Zhaohui Ao, Douglas G. Johns, Quinn Lu, Nabil Elshourbagy, Taylor L. Graham, Bradley J. Heidrich, Stephen A. Douglas, Gerald E. Hunsberger
Publikováno v:
Biochemical and Biophysical Research Communications. 358:145-149
Dendroaspis natriuretic peptide (DNP) is a newly-described natriuretic peptide which lowers blood pressure via vasodilation. The natriuretic peptide clearance receptor (NPR-C) removes natriuretic peptides from the circulation, but whether DNP interac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64c319378bc978f812c096a063293d5f
https://doi.org/10.1016/j.bbrc.2007.04.079
https://doi.org/10.1016/j.bbrc.2007.04.079
Exaggerated responses to inhaled irritant chemicals are a hallmark of human airway diseases such as asthma. While the inflammatory processes and structural remodeling caused by respiratory irritants have received considerable attention, the mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c343ee05f7595e9f774026682beef91
https://doi.org/10.1016/b978-0-12-420024-1.00010-2
https://doi.org/10.1016/b978-0-12-420024-1.00010-2
