Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Gerald E. Dodson"'
Autor:
Gerald E. Dodson, Anthony T. Trinh, Yuling Shi, Naval P. Shanware, Partha S. Mukhopadhyay, Randal S. Tibbetts
Publikováno v:
Journal of Biological Chemistry. 282:9236-9243
The functionally related ATM (ataxia telangiectasia-mutated) and ATR (ATM-Rad3-related) protein kinases are critical regulators of DNA damage responses in mammalian cells. ATM and ATR share highly overlapping substrate specificities and show a strong
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a939c51270df7da6585ab07bd2bde19
https://doi.org/10.1074/jbc.m609256200
https://doi.org/10.1074/jbc.m609256200
Publikováno v:
Journal of Biological Chemistry. 280:40195-40200
The structurally related ATM (ataxia-telangiectasia-mutated) and ATR (ATM-Rad3-related) protein kinases fulfill overlapping yet non-redundant functions as key regulators of cellular DNA damage responses. We recently showed that ATM phosphorylates the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f45774b147a1f7d5d2750c9a0bdea337
https://doi.org/10.1074/jbc.c500400200
https://doi.org/10.1074/jbc.c500400200
Autor:
Yuling Shi, Sujatha L. Venkataraman, Angela M. Mabb, Scott E. LeBlanc, Randal S. Tibbetts, Gerald E. Dodson
Publikováno v:
Proceedings of the National Academy of Sciences. 101:5898-5903
Ataxia–telangiectasia (A–T) is a syndrome of cancer susceptibility, immune dysfunction, and neurodegeneration that is caused by mutations in the A–T-mutated ( ATM ) gene. ATM has been implicated as a critical regulator of cellular responses to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e34721717b5fb980ff407c9b2b73c1f
https://doi.org/10.1073/pnas.0307718101
https://doi.org/10.1073/pnas.0307718101
Phosphorylation-regulated binding of Ctp1 to Nbs1 is critical for repair of DNA double-strand breaks
Publikováno v:
Cell cycle (Georgetown, Tex.). 9(8)
Repair of DNA double-strand breaks (DSBs) is critical for cell survival and for maintaining genome stability in eukaryotes. In Schizosaccharomyces pombe, the Mre11-Rad50-Nbs1 (MRN) complex and Ctp1 cooperate to perform the initial steps that process
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab82cf4a65aefb2049437211b40db05d
https://pubmed.ncbi.nlm.nih.gov/20421724
https://pubmed.ncbi.nlm.nih.gov/20421724
Autor:
J. N. Mark Glover, Jessica S. Williams, Yoshiki Yamada, Scott Classen, Grant Guenther, Gerald E. Dodson, Hiroshi Iwasaki, John A. Tainer, Paul Russell, Oliver Limbo, R. Scott Williams
Summary The Nijmegen breakage syndrome 1 (Nbs1) subunit of the Mre11-Rad50-Nbs1 (MRN) complex protects genome integrity by coordinating double-strand break (DSB) repair and checkpoint signaling through undefined interactions with ATM, MDC1, and Sae2/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::216bcf6266affb4d39e3801ae3d1b22a
https://europepmc.org/articles/PMC2762657/
https://europepmc.org/articles/PMC2762657/
Autor:
David A. Wassarman, Gerald E. Dodson, Rebeccah J. Katzenberger, Stacey A. Rimkus, Anthony T. Trinh, Randal S. Tibbetts
Publikováno v:
Genesdevelopment. 22(9)
Mutations in ATM (Ataxia telangiectasia mutated) result in Ataxia telangiectasia (A-T), a disorder characterized by progressive neurodegeneration. Despite advances in understanding how ATM signals cell cycle arrest, DNA repair, and apoptosis in respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48a2f3d93fcb2864c922651e79408eed
https://pubmed.ncbi.nlm.nih.gov/18408079
https://pubmed.ncbi.nlm.nih.gov/18408079
Autor:
Gerald E. Dodson, Randal S. Tibbetts
Publikováno v:
The Journal of biological chemistry. 281(3)
The DNA damage-response regulators ATM (ataxia-telangiectasia-mutated) and ATR (ATM-Rad3-related) are structurally and functionally related protein kinases that exhibit nearly identical substrate specificities in vitro. Current paradigms hold that th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fac96f8288470393bae69d53a3d5f8aa
https://pubmed.ncbi.nlm.nih.gov/16293623
https://pubmed.ncbi.nlm.nih.gov/16293623
Publikováno v:
Cell cycle (Georgetown, Tex.). 4(11)
Hydroxyurea (HU) is a competitive inhibitor of ribonucleotide reductase that is used for the treatment of myeloproliferative disorders. HU inhibits DNA replication and induces apoptosis in a cell type-dependent manner, yet the relevant pathways that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6441a6b2cb53965788e739eb4aa63352
https://pubmed.ncbi.nlm.nih.gov/16258278
https://pubmed.ncbi.nlm.nih.gov/16258278
Publikováno v:
The Journal of biological chemistry. 279(32)
Replication protein A (RPA) is a heterotrimeric, single-stranded DNA-binding complex comprised of 70-kDa (RPA1), 32-kDa (RPA2), and 14-kDa (RPA3) subunits that is essential for DNA replication, recombination, and repair in eukaryotes. In addition, re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a453596f4edb05c9f31ce415ae9a2d0d
https://pubmed.ncbi.nlm.nih.gov/15197179
https://pubmed.ncbi.nlm.nih.gov/15197179
Autor:
Gerald E. Dodson, Paul Russell
Publikováno v:
Molecular and Cellular Biology. 31:1936-1937
Double-strand breaks (DSBs) in chromosomal DNA elicit a rapid signaling response through the ATM protein kinase. ATM corresponds to Tel1 in budding yeast. Here we show that the catalytic activity of Tel1 is altered by protein binding at DNA ends via
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::574b93d01a156603d64e40e6230a072e
https://doi.org/10.1128/mcb.05386-11
https://doi.org/10.1128/mcb.05386-11