Výsledky vyhledávání - "Gerald E. Adams"

Modification of metabolism of transplantable and spontaneous murine tumors by the nitric oxide synthase inhibitor, nitro-L-arginine

Autor: J. M. Sansom, Gerald E. Adams, Csaba Szabó, Pauline J. Wood, Christoph Thiemermann, Ian J. Stratford, John R. Vane

Publikováno v: International Journal of Radiation Oncology*Biology*Physics. 29:443-447

Purpose: To determine the effects of the nitric oxide synthase inhibitor, nitro-L-arginine on energy metabolism in transplantable and spontaneous murine tumors. Methods and Materials: The responses of the transplantable murine tumor SCCVII/Ha and a r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45a5934bae022568cafa6fedb7f61399
https://doi.org/10.1016/0360-3016(94)90435-9

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Bioreductive drugs for cancer therapy: The search for tumor specificity

Autor: Ian J. Stratford, Gerald E. Adams

Publikováno v: International Journal of Radiation Oncology*Biology*Physics. 29:231-238

The activity of three different classes of bioreductive drug, i.e., heterocyclic nitro compounds, N -oxides and quinones are compared. The major characteristics of RB-6145, tirapazamine and E09 are summarized and future directions for development of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c09037521b163cd9b9f1eef0c6678e1a
https://doi.org/10.1016/0360-3016(94)90267-4

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The role of DT-diaphorase in determining the sensitivity of human tumor cells to tirapazamine (SR 4233)

Autor: J. Carmichael, N Robertson, Adam V. Patterson, Ian J. Stratford, S. Houlbrook, Gerald E. Adams, Adrian L. Harris, Stephens Ma

Publikováno v: International Journal of Radiation Oncology*Biology*Physics. 29:369-372

Purpose: To determine the dependency of the aerobic and hypoxic toxicity of tirapazamine on the intracellular activity of DT-diaphorase. Methods and Materials: A panel of 18 human cell lines comprising predominantly small cell and nonsmall cell lung

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c8270d95209e4ba5ffa218ce7613e0e
https://doi.org/10.1016/0360-3016(94)90291-7

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Radiolytic and photochemical reduction of the hypoxic cytotoxin 1,2-dihydro-8-(4-methylpiperazinyl)-4-phenylimidazo [1,2-a] pyrido [3,2-e] pyrazine 5-oxide (RB90740) and a potential mechanism for hypoxia-selective toxicity

Autor: John Nolan, E. Martin Fielden, Matthew A. Naylor, Peter O'Neill, Bridget M. Sutton, Gerald E. Adams, Ian J. Stratford

Publikováno v: International Journal of Radiation Oncology*Biology*Physics. 29:333-337

To study the reduction of RB90740 (1), a fused pyrazine mono-N-oxide that has an oxic:hypoxic cytotoxicity ratio of10 in a range of murine and human tumor cells in vitro.Reduction of 1 has been initiated radiolytically and photochemically in aqueous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c7d4b3b0d1259c7b551fe638408fb35
https://doi.org/10.1016/0360-3016(94)90285-2

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31P MRS to monitor the induction of tumor hypoxia by the modification of the oxygen affinity of hemoglobin using BW 589C

Autor: Christopher J.R. Counsell, Ian J. Stratford, Gerald E. Adams, J. M. Sansom, Pauline J. Wood, J. C. M. Bremner, Radhika Kalra

Publikováno v: International Journal of Radiation Oncology*Biology*Physics. 29:285-288

Purpose: BW 589C induces severe tumor hypoxia by modifying the affinity of oxyhemoglobin, causing a left shift of the oxygen-hemoglobin dissociation curve. 31 P magnetic resonance spectra (MRS) was used to monitor the effects of BW 589C on tumor ener

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::371347dc0a829cf615d27ef43af5e8d4
https://doi.org/10.1016/0360-3016(94)90276-3

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ChemInform Abstract: Reactions of Indolic Radicals Produced Upon One-Electron Oxidation of 5,6-Dihydroxyindole and Its N(1)-Methylated Analogue

Autor: Gerald E. Adams, Robert B. Cundall, Peter O'Neill, A.T. Al-Kazwini, G. Lang, Alex Junino

Publikováno v: ChemInform. 23

The reactions of indole semiquinone radicals produced following one-electron oxidation of 5,6-dihydroxyindole (DHI) and its N-methyl-substituted analogue (MeDHI) have been studied using pulse radiolysis with spectrophotometric detection in the pH ran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9d6c137594065c233d48e7441fc3c767
https://doi.org/10.1002/chin.199213115

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Direct observation of the reaction of the quinone-methide from 5,6-dihydroxyindole with the nucleophilic azide ion

Autor: Peter O'Neill, Robert B. Cundall, Alex Junino, Jean Maignan, Gerald E. Adams, A.T. Al-Kazwini

Publikováno v: Tetrahedron Letters. 33:3045-3048

Investigation of the oxidation of melanagenic intermediates and, in particular, the ultimate oxidative polymerisation of 5,6-dihydroxyindole (1) is important for a comprehensive understanding of the biosynthesis of melanin. Oxidation of 1 leads to th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0e7d111a231dd86a6517aa868681e2f4
https://doi.org/10.1016/s0040-4039(00)79596-7

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The response of spontaneous and transplantable murine tumors to vasoactive agents measured by 31p magnetic resonance spectroscopy

Autor: J. M. Sansom, Bruce M Cattanach, Pauline J. Wood, Gerald E. Adams, Roland M Quinney, Ian J. Stratford

Publikováno v: International Journal of Radiation Oncology*Biology*Physics. 22:473-476

31P magnetic resonance spectroscopy has been used to compare the effects of the vasoactive agents hydralazine and flunarizine on the oxygenation of the transplantable tumors, SCCVII/Ha and 16C, and a range of spontaneous mammary tumors arising in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43c672c4e223fafc9813abdd12d7fb83
https://doi.org/10.1016/0360-3016(92)90856-d

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