Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Gerald D. Frenkel"'
Autor:
Lorna Rodriguez-Rodriguez, Paula B. Caffrey, Muthu N. Kumaran, Mira Hellmann, Wilberto Nieves-Neira, Brian Buckley, Michael P. Kane, Murugesan Gounder, Darlene Gibbon, Gerald D. Frenkel, Mihae Song, Weichung Shih, Ami Vaidya
Publikováno v:
Gynecologic oncology. 150(3)
Purpose Preclinical studies performed in our laboratory have shown that high-dose selenium inhibits the development of carboplatin drug resistance in an ovarian cancer mouse xenograft model. Based on these data, as well as the potential serious toxic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7cd854437723967f5e18f422a2dae26
https://pubmed.ncbi.nlm.nih.gov/30068487
https://pubmed.ncbi.nlm.nih.gov/30068487
Publikováno v:
In vivo (Athens, Greece). 30(6)
Background/aim To study the prevention of chemotherapy resistance, we have previously designed models of drug-resistant ovarian cancer. We here report an in vivo model of cisplatin-resistant small cell lung cancer (SCLC). Materials and methods Mice b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a02324d8b18bd2c23da8f55a1b56a43
https://pubmed.ncbi.nlm.nih.gov/27815457
https://pubmed.ncbi.nlm.nih.gov/27815457
Publikováno v:
Cancer Letters. 136:47-52
Exposure of A2780 human ovarian tumor cells to a low concentration of melphalan in vitro for 7 days resulted in the development of melphalan resistance. This resistance was not a stable characteristic of the cells since it was lost after 2 weeks in c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc3ef59ff5e845eb0ee6fed06266ed2b
https://doi.org/10.1016/s0304-3835(98)00307-3
https://doi.org/10.1016/s0304-3835(98)00307-3
Publikováno v:
Biological Trace Element Research. 65:187-195
Exposure of A2780 human ovarian tumor cells to a low concentration of melphalan in vitro for 7 d results in the development of melphalan resistance, which is dependent on elevated cellular levels of glutathione and glutathione S-transferase. The incl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae262681af195b31a4f8619a99c12086
https://doi.org/10.1007/bf02789095
https://doi.org/10.1007/bf02789095
Publikováno v:
Biological Trace Element Research. 62:123-134
We previously reported that exposure of HeLa cells to selenite for 2 h results in a decrease in their ability to attach to fibronectin (Yan and Frenkel, Cancer Res. 52, 5803-5807 [1992]), as well as a decrease in the level of fibronectin receptor (al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d55b55e8ff93c7af5daa1f6e864bdde
https://doi.org/10.1007/bf02783966
https://doi.org/10.1007/bf02783966
Autor:
Paula B, Caffrey, Gerald D, Frenkel
Publikováno v:
Anticancer research. 33(10)
We have been exploring a prevention approach to the problem of drug resistance which develops during ovarian cancer chemotherapy. We have previously described an in vivo model of the development of resistance to the chemotherapy drug cisplatin in xen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::12bfcff689b22595d55ca2553948905c
https://pubmed.ncbi.nlm.nih.gov/24122988
https://pubmed.ncbi.nlm.nih.gov/24122988
Selenite enhances and prolongs the efficacy of cisplatin treatment of human ovarian tumor xenografts
Autor:
Paula B, Caffrey, Gerald D, Frenkel
Publikováno v:
In vivo (Athens, Greece). 26(4)
Our earlier studies on ovarian tumor xenografts provide evidence that co-treatment with selenite prevents the development of resistance to single-treatment using the drug cisplatin. However, these studies did not reflect the repetitive schedule of cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6d9c3e49e6529607f3c227c5aedb5a6c
https://pubmed.ncbi.nlm.nih.gov/22773566
https://pubmed.ncbi.nlm.nih.gov/22773566
Autor:
Gerald D. Frenkel, Lin Yan
Publikováno v:
Biological Trace Element Research. 46:79-89
Incubation of cells with selenite, under conditions in which there is no effect on cell viability, results in a decrease in the rate of their subsequent attachment to extracellular matrix proteins such as fibronectin (1). The attachment was inhibited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::409706a6e55a2d0fbb1cd17578bae497
https://doi.org/10.1007/bf02790069
https://doi.org/10.1007/bf02790069
Autor:
Yuhong Gong, Gerald D. Frenkel
Publikováno v:
Cancer Letters. 78:195-199
Pre-exposure of HeLa or NIH:OVCAR-3 cells to selenite resulted in a dose-dependent decrease in the ability of the cells to invade a layer of Matrigel, a reconstituted basement membrane preparation. In contrast, selenate, selenomethionine and sulfite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a969688621f52da8d4d421461e46213
https://doi.org/10.1016/0304-3835(94)90051-5
https://doi.org/10.1016/0304-3835(94)90051-5
Autor:
Christina MacVicar, Gerald D. Frenkel
Publikováno v:
Biological Trace Element Research. 39:139-147
The effect of cell density on the sensitivity of tumor cells to selenite has been examined. The inhibitory effect of selenite on cellular DNA and RNA synthesis was significantly greater in higher density cultures of HeLa cells and A2780 ovarian tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59e67fb1d4b6e0315c74498b2a2c3625
https://doi.org/10.1007/bf02783184
https://doi.org/10.1007/bf02783184