Výsledky vyhledávání - "Gerald C. Wallace"

Precision Therapy for Brain Tumors in Hereditary Syndromes

Autor: Madeleine Tjoelker, Kaitlyn Bartley, Gerald C. Wallace, John W. Henson

Publikováno v: Current Treatment Options in Oncology. 22

Nervous system tumors arising in the setting of monogenic, hereditary cancer predisposition syndromes are unique in that the initiating genetic event in tumor formation is known. This knowledge provides a powerful treatment approach if the alteration

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e073fc57e6f034dccaa29fd89684b144
https://doi.org/10.1007/s11864-021-00876-7

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Precision Therapy for Brain Tumors in Hereditary Syndromes

Autor: Gerald C, Wallace, Madeleine, Tjoelker, Kaitlyn, Bartley, John W, Henson

Publikováno v: Current treatment options in oncologyReferences and Recommended ReadingPapers of particular interest, published recently, have been highlighted as: • Of importance. 22(9)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d4f392bff1563b2eece936ec5fc48bfa
https://pubmed.ncbi.nlm.nih.gov/34415424

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Single agent efficacy of the HDAC inhibitor DATS in preclinical models of glioblastoma

Autor: Gerald C. Wallace, Fraser Henderson, Abhay K. Varma, David Cachia, William A. Vandergrift, Scott Lindhorst, Narendra L. Banik, Sunil J. Patel, Libby Kosnik Infinger, Stephen Lowe, Pierre Giglio, Arabinda Das

Publikováno v: Cancer Chemotherapy and Pharmacology. 82:945-952

Glioblastoma (GB) remains incurable despite aggressive chemotherapy, radiotherapy, and surgical interventions; immunotherapies remain experimental in clinical practice. Relevant preclinical models that can accurately predict tumor response to therapy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f187a922e7859b7aebaf54f7c55249fd
https://doi.org/10.1007/s00280-018-3684-7

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Paraneoplastic Limbic Encephalitis Secondary To Mixed Non-Seminomatous Germ Cell Tumours

Autor: Asad Ullah, Gerald C. Wallace, Edward J. Kruse, Saleh Heneidi, Chase J. Wehrle, Margaret A. Sinkler, Zachary Klaassen, Nikhil Patel, Fenwick T. Nichols, Paul D. Biddinger

Publikováno v: American Journal of Clinical Pathology. 154:S55-S56

Casestudy: Testicular tumors account for 1–2% of all tumors in men, with 95% of these being germ cell tumors. The main risk factor for the development of testicular cancer is cryptorchidism. Paraneoplastic limbic encephalitis is a rare sequela of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5efc28d90f9fa1b51e6d5eea81e0af1b
https://doi.org/10.1093/ajcp/aqaa161.119

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PATH-38. METASTATIC MENINGIOMA CAUSING CHRONIC RESPIRATORY FAILURE

Autor: Gerald C. Wallace, Samantha Mattox, Suash Sharma, Ambika Sood, Nichols Fenwick, Dhiren Wallace, John R. Vender

Publikováno v: Neuro Oncol

Meningiomas are the most common primary intracranial tumor accounting for almost 37% of all CNS tumors. Malignant meningiomas are uncommon, accounting for 0.5% of all meningiomas. Malignant meningioma that is metastatic outside the cranium/skull is e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04f32ebc405ac019db8a228378cba8f3
https://doi.org/10.1093/neuonc/noaa215.719

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Multi-targeted DATS prevents tumor progression and promotes apoptosis in ectopic glioblastoma xenografts in SCID mice via HDAC inhibition

Autor: Gerald C. Wallace, W. Alex Vandergrift, Naren L. Banik, Catherine P. Haar, Sunil J. Patel, Swapan K. Ray, Yaenette N. Dixon-Mah, Arabinda Das, Abhay K. Varma, Pierre Giglio

Publikováno v: Journal of Neuro-Oncology. 114:43-50

Glioblastoma, the most lethal brain tumor, remains incurable despite aggressive chemotherapy and surgical interventions. New chemotherapeutics for glioblastoma have been explored in preclinical models and some agents have reached the clinical setting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::50b383a6457d163eff6eebe1dd94f878
https://doi.org/10.1007/s11060-013-1165-8

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Targeting oncogenic ALK and MET: a promising therapeutic strategy for glioblastoma

Autor: Gerald C. Wallace, Pierre Giglio, W. Alex Vandergrift, Catherine P. Haar, Arabinda Das, Sunil J. Patel, Swapan K. Ray, Yaenette N. Dixon-Mah, Naren L. Banik, Amber M. Mittendorf

Publikováno v: Metabolic Brain Disease. 28:355-366

Glioblastoma is the most common aggressive, highly glycolytic, and lethal brain tumor. In fact, it is among the most commonly diagnosed lethal malignancies, with thousands of new cases reported in the United States each year. Glioblastoma's lethality

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6be648baaccb08cc13d354ad886f70e9
https://doi.org/10.1007/s11011-013-9401-7

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Hippocampal tissue of patients with refractory temporal lobe epilepsy is associated with astrocyte activation, inflammation, and altered expression of channels and receptors

Autor: Naren L. Banik, Joshua A. Smith, Swapan K. Ray, Steven S. Glazier, Jonathan C. Edwards, Misty L. McDowell, Casey O. Holmes, Gerald C. Wallace, Arabinda Das, Leonardo Bonilha, Jennifer D Marshall

Publikováno v: Neuroscience. 220:237-246

Temporal lobe epilepsy (TLE) is the most common form of focal epilepsy. Previous research has demonstrated several trends in human tissue that, undoubtedly, contribute to the development and progression of TLE. In this study we examined resected huma

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https://doi.org/10.1016/j.neuroscience.2012.06.002

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Overexpression of melatonin membrane receptors increases calcium-binding proteins and protects VSC4.1 motoneurons from glutamate toxicity through multiple mechanisms

Autor: Gerald C. Wallace, Russel J. Reiter, Swapan K. Ray, Arabinda Das, Naren L. Banik, Abhay K. Varma

Publikováno v: Journal of Pineal Research. 54:58-68

Melatonin has shown particular promise as a neuroprotective agent to prevent motoneuron death in animal models of both amyotrophic lateral sclerosis (ALS) and spinal cord injuries (SCI). However, an understanding of the roles of endogenous melatonin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d9715871fb0895610431827165502043
https://doi.org/10.1111/j.1600-079x.2012.01022.x

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