Zobrazeno 1 - 10
of 189
pro vyhledávání: '"Gerald C. Smaldone"'
Publikováno v:
Pharmaceutics, Vol 16, Iss 2, p 182 (2024)
Aerosol delivery using conventional nebulizers with fixed maximal output rates is limited and unpredictable under high-flow conditions. This study measured regulated aerosol delivery to the lungs of normal volunteers using a nebulizer designed to ove
Externí odkaz:
https://doaj.org/article/20eb725f5855496a8daaa233a9239a63
Publikováno v:
Respiratory Research, Vol 20, Iss 1, Pp 1-14 (2019)
Abstract Background Idiopathic pulmonary fibrosis (IPF) pathogenesis involves multiple pathways, and combined antifibrotic therapy is needed for future IPF therapy. Inhaled interferon-γ (IFN-γ) was recently shown to be safe and without systemic eff
Externí odkaz:
https://doaj.org/article/7e6e5f6a10d14089a5f96c00955c4c1d
Autor:
Jing Wang, Melissa Lesko, Michelle H. Badri, Bianca C. Kapoor, Benjamin G. Wu, Yonghua Li, Gerald C. Smaldone, Richard Bonneau, Zachary D. Kurtz, Rany Condos, Leopoldo N. Segal
Publikováno v:
ERJ Open Research, Vol 3, Iss 3 (2017)
Therapies targeting inflammation reveal inconsistent results in idiopathic pulmonary fibrosis (IPF). Aerosolised interferon (IFN)-γ has been proposed as a novel therapy. Changes in the host airway microbiome are associated with the inflammatory mili
Externí odkaz:
https://doaj.org/article/d921d16bec0a413f8b93cf2ff135c5d7
Autor:
Chen S. Tsai, Rong W. Mao, Shirley C. Tsai, Kaveh Shahverdi, Yun Zhu, Shih K. Lin, Yu-Hsiang Hsu, Gerry Boss, Matt Brenner, Sari Mahon, Gerald C. Smaldone
Publikováno v:
Micromachines, Vol 8, Iss 2, p 56 (2017)
An in-depth review on a new ultrasonic micro-droplet generator which utilizes megahertz (MHz) Faraday waves excited by silicon-based multiple Fourier horn ultrasonic nozzles (MFHUNs) and its potential applications is presented. The new droplet genera
Externí odkaz:
https://doaj.org/article/1f1ec22bcb454a57a08d542b0205fded
Publikováno v:
Journal of Aerosol Medicine and Pulmonary Drug Delivery.
Autor:
Michael McPeck, Gerald C. Smaldone
Publikováno v:
Expert Opinion on Drug Delivery. 19:465-474
Critically ill mechanically ventilated patients routinely receive aerosol delivery of epoprostenol by continuous infusion of the nebulizer by syringe pump. This procedure is ‘off-label’ as no FDA approved drug presently exists. Without standardiz
Autor:
Lucy B. Palmer, Gerald C. Smaldone
Publikováno v:
Journal of Aerosol Medicine and Pulmonary Drug Delivery. 35:11-24
Respiratory infection is common in intubated/tracheotomized patients and systemic antibiotic therapy is often unrewarding. In 1967, the difficulty in treating Gram-negative respiratory infections led to the use of inhaled gentamicin, targeting therap
Publikováno v:
Journal of Aerosol Medicine and Pulmonary Drug Delivery. 35:32-40
Background: A new real-time method for assessing factors determining aerosol delivery is described. Methods: A breath-enhanced jet nebulizer operated in a ventilator/heated humidifier system was te...
Autor:
Jignesh K. Patel, Rajeev B. Patel, Ewa Rakowski, Gerald C. Smaldone, Adam J. Singer, Puja B. Parikh, Wei Hou, Sahar Ahmad, Elinor Schoenfeld
Publikováno v:
Nitric Oxide. 115:30-33
While inhaled nitric oxide (iNO) has revealed benefit in cardiac arrest in an animal model, no published data has yet demonstrated the impact of iNO in humans with cardiac arrest.In this pilot study, we administered iNO, along with standard post-resu
Publikováno v:
Respir Care
BACKGROUND: Continuous nebulization of prostacyclins and albuterol by infusion pump during mechanical ventilation evolved as a popular off-label treatment for severe hypoxemic respiratory failure and asthma. Most institutions use a vibrating mesh neb