Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Gerald B. Grindey"'
Where do you begin to look for a recent, authoritative article on the diagnosis or management of a particular malignancy? The few general oncology textbooks are generally out of date. Single papers in specialized journals are informative but seldom c
, Adrenal and Endocrine Tumors in Children'is the third volume in the series,'Cancer Treatment and Research'devoted to pediatric oncology. Like its predecessors, it is organized into two sections. The first section again deals with issues of basic re
Where do you begin to look for a recent, authoritative article on the diagnosis or management of a particular malignancy? The few general onco logy textbooks are generally out of date. Single papers in specialized journals are informative but seldo
Autor:
Richard M. Schultz, William J. Ehlhardt, John F. Worzalla, Jesse R. Bewley, John E. Toth, Kim K. Klingerman, James Edward Ray, George B. Boder, Gerald B. Grindey, Sharon M. Rinzel, Susan B. Gates, Leonard C. Weir
Publikováno v:
Journal of Medicinal Chemistry. 40:1018-1025
A series of sulfonimidamide analogs of the oncolytic diarylsulfonylureas was synthesized and evaluated for (1) in vitro cytotoxicity against CEM cells, (2) in vivo antitumor activity against subaxillary implanted 6C3HED lymphosarcoma, and (3) metabol
Autor:
P. G. Rutherford, Richard M. Schultz, Larry Wayne Hertel, Ronald L. Merriman, George B. Boder, Gerald B. Grindey, Lee R. Tanzer, J. A. Houghton, Peter J. Houghton
Publikováno v:
Investigational New Drugs. 14:243-247
Gemcitabine is a new deoxycytidine analog that exhibits significant cytotoxicity against a variety of cultured murine and human tumor cells. The cytotoxic action of gemcitabine appears to be due to the inhibition of DNA synthesis by inhibition of rib
Autor:
Manohar Ratnam, Gerald B. Grindey, Lynn S. Gossett, Laurane G. Mendelsonn, William Kohler, Lillian L. Habeck, John F. Worzalla, Susan B. Gates, Richard M. Schultz, Chuan Shih, Sherri L. Andis
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:473-476
A novel series of dihydrofolate reductase inhibitors was uncovered during an expansion of the SAR of 5,10-dideazatetrahydrofolic acid, and their biological activity was evaluated. These new analogs do not possess an oxygen at the 4 position and conta
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:513-518
A series of tritylated difluorodeoxynucleosides represent novel prodrugs in which there exists a predictable correlation between the electronic nature of the aromatic substituents on the trityl moiety and the acid mediated dissociation to free drug i
Autor:
Garth Powis, Rosanne Bonjouklian, Gerald B. Grindey, Ronald L. Merriman, Curtis L. Ashendel, Chris J. Vlahos, Leon H. Zalkow, Robert T. Abraham
Publikováno v:
International Journal of Pharmacognosy. 33:17-26
The intracellular signalling pathways that mediate the effects of growth factors and oncogenes on cell growth and transformation offer new targets for developing drugs for the treatment of cancer. This is a novel approach that presents new types of c
Publikováno v:
Journal of Pharmaceutical Sciences. 83:1396-1399
The effect of folic acid depletion on the tissue distribution and plasma pharmacokinetics of the oncolytic agent 5,10-dideazatetrahydrofolic acid (DDATHF) was evaluated in mice fed either folic acid-deficient or regular diets. Mice were maintained on
Publikováno v:
Biochemical Pharmacology. 48:319-325
To investigate the role of dietary folic acid in dideazatetrahydrofolate (DDATHF) sensitivity, reduced folates were estimated in plasma and tissue of mice following dietary depletion and repletion. Previous studies showed that DDATHF, a new folate an