Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Gerald A. Poore"'
Autor:
J. Jeffry Howbert, Eddie Vi-Ping Tao, Cora Sue Grossman, Gerald B. Grindey, Brent Jeffrey Rieder, W. N. Shaw, Gerald A. Poore, K. E. Kramer, Glen C. Todd, James Abraham Aikins, S M Rinzel, Richard Waltz Harper, Thomas Alan Crowell
Publikováno v:
ChemInform. 22
Autor:
K. E. Kramer, Cora Sue Grossman, Richard Waltz Harper, Brent Jeffrey Rieder, Gerald A. Poore, James Abraham Aikins, Eddie Vi-Ping Tao, Thomas Alan Crowell, S M Rinzel, J. Jeffry Howbert
Publikováno v:
Journal of Medicinal Chemistry. 33:2393-2407
A series of diarylsulfonylureas with exceptionally broad-spectrum activity against syngeneic rodent solid tumors in vivo is described. Their discovery resulted from a program dedicated to in vivo screening for novel oncolytics in solid tumor models,
Publikováno v:
Journal of Medicinal Chemistry. 20:409-413
A series of 4'-dehydrated derivatives of various dimeric Vinca alkaloids has been synthesized to further define the structure-activity relationships of Vinca alkaloids with onolytic potency. The concentrated sulfuric acid dehydration in most cases ga
Autor:
Michael Leroy Phillips, Gerald B. Grindey, Rosanne Bonjouklian, Marilyn G. Altom, Kathy M. Kuhler, Richard M. Schultz, Gerald A. Poore
Publikováno v:
Journal of Medicinal Chemistry. 29:2472-2477
Analogues of the synthetic antitumor phospholipid ALP (1-octadecyl-2-methyl-sn-glycero-3-phosphocholine; alkyl lysophospholipid) in which the 1-ether oxygen atom has been removed have been prepared and evaluated for in vitro and in vivo anticancer ac
Autor:
Kenneth J. Widder, Donald P. Howard, Robert M. Morris, Philip A. Marino, Gerald A. Poore, Andrew E. Senyei
Publikováno v:
European Journal of Cancer and Clinical Oncology. 19:141-147
Magnetic albumin microspheres (1 μ m average diameter) were selectively targeted to subcutaneous solid Yoshida sarcoma tumors (average size 450 mm 2 ) in Holtzman rats. This was accomplished by placing an external magnet adjacent to the tumor while
Publikováno v:
Advances in Enzyme Regulation. 9:51-61
Summary The activities of the first two enzymes in the pyrimidine biosynthetic pathway, carbamyl-aspartate-transferase (CATase) and dihydroorotase (DHOase), were measured in a series of Morris hepatomas; and they were compared to values from livers o
Publikováno v:
Journal of Pharmaceutical Sciences. 55:758-768
Utilizing a differential extraction technique for the examination of the bark of the Australian plant Acronychia Baueri Schott ( Bauerella australiana Borzi), has resulted in the isolation of the triterpene lupeol and the alkaloids melicopine, acrony
Publikováno v:
Journal of Pharmaceutical Sciences. 57:1720-1725
Inclusion in the authors' phytochemical screening program of plants of the family Apocynaceae related to Catharanthus roseus G. Don seemed logical in view of the success realized with the Madagascan periwinkle. Screening of the appropriate extracts o
Publikováno v:
Journal of medicinal chemistry. 22(4)
While structure-activity relationships for vinblastine (VLB), vincristine, deacetyl-VLB, and deacetyl-VLB amide (vindesine, VDS) in several tumor and leukemia models have been reported previously, the present study explores these relationships for a
Autor:
Gerald A. Poore, G. C. Todd, R. C. Hoying, R. L. Nelson, George Joseph Cullinan, R. L. Robison, Sweeney Mj, W. E. Jones, W. M. Newlon, Koert Gerzon, C. J. Barnett, R. W. Dyke
Publikováno v:
Journal of medicinal chemistry. 21(1)
Exploration of the effects of "minor" structural differences on the antitumor activity and toxicity of dimeric Catharanthus alkaloids resulted in the preparation of deacetylvinblastine amide (vindesine, VDS) from either vinblastine (VLB) or deacetylv