Výsledky vyhledávání - "Gerald A. Eddy"

Limited Protection from a Pathogenic Chimeric Simian-Human Immunodeficiency Virus Challenge following Immunization with Attenuated Simian Immunodeficiency Virus

Autor: Jack Greenhouse, Jennifer Bo Jiang, Deborah L. Birx, Yichen Lu, Terry Brennan, Jake Yalley-Ogunro, Mark G. Lewis, Gerald A. Eddy, Thomas C. VanCott

Publikováno v: Journal of Virology. 73:1262-1270

Two live attenuated single-deletion mutant simian immunodeficiency virus (SIV) constructs, SIV 239Δnef and SIV PBj6.6Δnef , were tested for their abilities to stimulate protective immunity in macaques. During the immunization period the animals wer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed51d1baaaee4665c797aa3fa4a2d515
https://doi.org/10.1128/jvi.73.2.1262-1270.1999

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Infectivity of titered doses of simian immunodeficiency virus clone E11S inoculated intravenously into rhesus macaques (Macaca mulatta)

Autor: J L Ribas, Stanford T. Roodman, Gerald A. Eddy, W B Knott, Raoul E. Benveniste, Mark G. Lewis, R W Hill

Publikováno v: Journal of Medical Primatology. 23:83-88

The macaque infectious dose (MID) of a single-cell clone of simian immunodeficiency virus isolated from a pig-tailed macaque (SIV/Mne clone E11S) was determined in rhesus macaques (Macaca mulatta). Twenty-one macaques were inoculated with 10-fold dil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::417a968d3de0dd84601fbede29b68807
https://doi.org/10.1111/j.1600-0684.1994.tb00106.x

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Phylogenetic analysis of gag genes from 70 international HIV-1 isolates provides evidence for multiple genotypes

Autor: Francine E. McCutchan, Martine Peeters, Donald S. Burke, Terrence P. Brennan, G. M. Gershy-Damet, Guido van der Groen, Joost Louwagie, Katrien Fransen, Gerald A. Eddy, Robert Deleys, Eric Sanders-Buell

Publikováno v: Scopus-Elsevier

To determine the extent of genetic variation among internationally collected HIV-1 isolates, to analyse phylogenetic relationships and the geographic distribution of different variants.Phylogenetic comparison of 70 HIV-1 isolates collected in 15 coun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f06ea6d37cbdcac50599a129ce1cfe3
https://doi.org/10.1097/00002030-199306000-00003

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Prevention of transmission of simian immunodeficiency virus from vaccinated macaques that developed transient virus infection following challenge

Autor: Mark G. Lewis, Gerald A. Eddy, Francine E. McCutchan, Raoul E. Benveniste, Peter B. Jahrling, Avigdor Shafferman, Donald S. Burke

Publikováno v: Vaccine. 11:848-852

Macaque immunization with a mixture of four SIV peptides from conserved hydrophilic envelope regions has been shown to prevent virus persistence following challenge with SIV mne/E11s . Data shown here demonstrate that lymph node cells from all vaccin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32bb9aadd9ab1bb2ee4d382568a7fbd3
https://doi.org/10.1016/0264-410x(93)90360-a

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Variation in the CD4 + and CD8 + populations in lymph nodes does not reflect that in the blood during SIV MNE/E11S infection of macaques

Autor: Avigdor Shafferman, Sue F. Papermaster, Gerald A. Eddy, Yvonne J. Rosenberg, Mark G. Lewis, Leon E, Donald S. Burke, Brian D. White, Raoul E. Benveniste

Publikováno v: Journal of Medical Primatology. 21:131-137

The decline in the CD4% and CD4/CD8 ratios have been compared in lymph nodes and blood from SIVMNE/E11S infected rhesus macaques. The results indicate that loss from the LN CD4+ cell pool does not occur until CD4/CD8 ratios of less than 0.5 is reache

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d2447d1518b3703c6ae4cdb5b82b0cd3
https://doi.org/10.1111/j.1600-0684.1992.tb00579.x

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Protection of macaques with a simian immunodeficiency virus envelope peptide vaccine based on conserved human immunodeficiency virus type 1 sequences

Autor: Mark G. Lewis, Donald S. Burke, Terri J. Phipps, Avigdor Shafferman, Gerald A. Eddy, Peter B. Jahrling, Francine Eden-McCutchan, Raoul E. Benveniste, Jerold Sadoff

Publikováno v: Scopus-Elsevier

This report describes the vaccination of rhesus macaques with peptides selected from regions of the simian immunodeficiency virus (SIV) envelope that are hydrophilic, immunoreactive, and highly homologous with corresponding conserved envelope sequenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59b712a9229b10c42a8300852d0ef322
https://doi.org/10.1073/pnas.88.16.7126

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Variation in T‐lymphocyte activation and susceptibility to SIV PBj‐14 ‐induced acute death in macaques

Autor: Mark G. Lewis, Donald S. Burke, Peter B. Jarling, Gerald A. Eddy, Philip M. Zack, Yvonne J. Rosenberg, Brian D. White, Sue F. Papermaster

Publikováno v: Journal of Medical Primatology. 20:206-210

In contrast to pig-tailed and cynomolgus macaques, which die in 6-10 days following infection with the SIV-PBj-14 isolate, only about 50% of rhesus succumbed to rapid disease. Using a CD45RA MAb that delineates memory (CD45RAlo), naive (CD45RAmed) an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2d9086e330a9ab169ae2334d7550bdd3
https://doi.org/10.1111/j.1600-0684.1991.tb00520.x

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Genetic Comparison of HIV-1 Isolates from Africa, Europe, and North America

Autor: Beth L. P. Ungar, Katrien Fransen, Martine Peeters, Joost Louwagie, Francine E. McCutchan, Guido van der Groen, Gerald A. Eddy, Georges Roelants, Donald S. Burke, G. M. Gershy-Damet, Peter Piot, Hugo Van Heuverswyn

Publikováno v: Scopus-Elsevier
Europe PubMed Central

Laboratory scientists used anchored polymerase chain reaction (PCR) and DNA sequencing to compare HIV-1 isolates from countries in Africa (Ivory Coast, Gabon, Zaire, Kenya, and others), Europe (Belgium and other countries), and the US. The US isolate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25347e05023e342dd7ffb0d0f4a4e9ff
https://doi.org/10.1089/aid.1992.8.1467

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Viral DNA burden and decline in percentage of CD4-positive cells in the lymphoid compartment of SIV-infected macaques

Autor: Gerald A. Eddy, Aurelio Cafaro, Jack Greenhouse, Mark G. Lewis, Enrique C. Leon, Yvonne J. Rosenberg

Publikováno v: AIDS research and human retroviruses. 10(10)

The decline in CD4+ cells and increased viral DNA and RNA burden in the blood of human immunodeficiency virus (HIV)-infected individuals have been used as closely related correlates of disease progression. However, little is known about levels of tot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84bb6daa5067ce700ceedf95a3757af1
https://pubmed.ncbi.nlm.nih.gov/7848682

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Immunological and virological changes associated with decline in CD4/CD8 ratios in lymphoid organs of SIV-infected macaques

Autor: Mark G. Lewis, E. Hall, P. M. Zack, Brian D. White, Gerald A. Eddy, Enrique C. Leon, Sue F. Papermaster, Yvonne J. Rosenberg, Jack Greenhouse

Publikováno v: AIDS research and human retroviruses. 10(7)

The decline in CD4/CD8 ratios in lymph nodes (LNs) of SIV macaques and HIV-infected individuals occurs later than that in blood. In a previous study, long-term SIV-infected macaques were delineated into two groups: (1) those whose LNs had normal CD4/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::419b036618bd32a8118d69be2215cca0
https://pubmed.ncbi.nlm.nih.gov/7986591

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