Reversible translocation of acyl-CoA:cholesterol acyltransferase (ACAT) between the endoplasmic reticulum and vesicular structures

Autor: Andrea Schiffmann, Lena Ahlswede, Gerald Gimpl

Publikováno v: Frontiers in Molecular Biosciences, Vol 10 (2023)

The enzyme acyl-CoA:cholesterol acyltransferase (ACAT) is normally localized in the endoplasmic reticulum (ER) where it can esterify cholesterol for storage in lipid droplets and/or the formation of lipoproteins. Here, we report that ACAT can translo

Externí odkaz: https://doaj.org/article/a3702cc5f9c8488f8524ef4d3c47168d

OXTR-Related Markers in Clinical Depression: a Longitudinal Case–Control Psychotherapy Study

Autor: Gerald Gimpl, Manfred E. Beutel, Marian J. Bakermans-Kranenburg, Iris Reiner, Helge Frieling

Publikováno v: Journal of Molecular Neuroscience, 72(4), 695-707. Humana Press
Reiner, I C, Gimpl, G, Beutel, M E, Bakermans-Kranenburg, M J & Frieling, H 2022, ' OXTR-Related Markers in Clinical Depression: a Longitudinal Case–Control Psychotherapy Study ', Journal of Molecular Neuroscience, vol. 72, no. 4, pp. 695-707 . https://doi.org/10.1007/s12031-021-01930-7

We investigated stability and change of plasma and urinary oxytocin as well as OXTR DNA methylation patterns through psychotherapy. Furthermore, we explored the potential impact of inpatient psychotherapy on oxytocin-related biomarkers and vice versa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afaf48920d40492014aecfe6f32c71ad
https://research.vu.nl/en/publications/ce83a07c-2fb4-45bd-819d-3e0badc7d45d

Vasopressin and oxytocin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Autor: Michel Bouvier, Stephen J Lolait, Hans H. Zingg, Mark Wheatley, Gilles Guillon, Melvyn Soloff, Tadashi Kimura, Claudine Serradeil-Le Gal, Bice Chini, Anne-Marie O'Carroll, Gerald Gimpl, Joseph G. Verbalis, D. G. Bichet, Mark A. Knepper, Maurice Manning, Bernard Mouillac

Publikováno v: Bichet, D, Bouvier, M, Chini, B, Gimpi, G, Guillon, G, Kimura, T, Knepper, M, Lolait, S J, Manning, M, Mouillac, B, O'Carroll, A-M, Serradeil-Le Gal, C, Soloff, M, Verbalis, J, Wheatlry, M & Zingg, H 2019, ' Vasopressin and oxytocin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database ', IUPHAR/BPS Guide to PHarmacology CITE, vol. 2019, no. 4 . https://doi.org/10.2218/gtopdb/F66/2019.4

Vasopressin (AVP) and oxytocin (OT) receptors (nomenclature as recommended by NC-IUPHAR [92]) are activated by the endogenous cyclic nonapeptides vasopressin and oxytocin. These peptides are derived from precursors which also produce neurophysins (ne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dcaf377e041ee5403c3b48762ce3acb
https://doi.org/10.2218/gtopdb/f66/2019.4

Synthesis and characterization of a novel rhodamine labeled cholesterol reporter

Autor: Olivia Bauer, Alexander Maiwald, Gerald Gimpl

Publikováno v: Biochimica et biophysica acta. Biomembranes. 1859(6)

We introduce the novel fluorescent cholesterol probe RChol in which a sulforhodamine group is linked to the sixth carbon atom of the steroid backbone of cholesterol. The same position has recently been selected to generate the fluorescent reporter 6-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ba0ef349e3169d4d659ce5e9764b9e4
https://pubmed.ncbi.nlm.nih.gov/28257814

Oxidative stress resistance in hippocampal cells is associated with altered membrane fluidity and enhanced nonamyloidogenic cleavage of endogenous amyloid precursor protein

Autor: Christian Behl, Gerald Gimpl, Angela B. Clement

Publikováno v: Free Radical Biology and Medicine. 48:1236-1241

Reactive oxygen species (ROS) have important roles as signaling molecules in the regulation of a variety of biological processes. On the other hand, chronic oxidative stress exerted by ROS is widely considered a causative factor in aging. Therefore,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e7dc64c95bdc31b9de00358d0d4619d
https://doi.org/10.1016/j.freeradbiomed.2010.02.008