A biosensor of protein foldedness identifies increased "holdase" activity of chaperones in the nucleus following increased cytosolic protein aggregation.

Autor: Raeburn CB; Department of Biochemistry and Pharmacology, and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, VIC, Australia., Ormsby AR; Department of Biochemistry and Pharmacology, and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, VIC, Australia., Cox D; Department of Biochemistry and Pharmacology, and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, VIC, Australia., Gerak CA; Department of Biochemistry and Pharmacology, and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, VIC, Australia., Makhoul C; Department of Biochemistry and Pharmacology, and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, VIC, Australia., Moily NS; Department of Biochemistry and Pharmacology, and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, VIC, Australia., Ebbinghaus S; Physical and Theoretical Chemistry, TU Braunschweig, 38106 Germany and Braunschweig Integrated Centre of Systems Biology, Braunschweig, Germany., Dickson A; Department of Biochemistry & Molecular Biology, Michigan State University, East Lansing, Michigan, USA., McColl G; Melbourne Dementia Research Centre, Florey Institute of Neuroscience and Mental Health and University of Melbourne, Parkville, VIC, Australia., Hatters DM; Department of Biochemistry and Pharmacology, and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, VIC, Australia. Electronic address: dhatters@unimelb.edu.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2022 Aug; Vol. 298 (8), pp. 102158. Date of Electronic Publication: 2022 Jun 17.