Zobrazeno 1 - 10
of 135
pro vyhledávání: '"Geraint Davies"'
Autor:
Kathryn A. Haigh, Hussein H. Twabi, Linda Boloko, Phiona E. Namale, Vittoria Lutje, Sarah Nevitt, Geraint Davies
Publikováno v:
EClinicalMedicine, Vol 77, Iss , Pp 102857- (2024)
Summary: Background: Tuberculosis (TB) remains a significant cause of mortality globally, yet first-line treatment has hardly changed for fifty years. The dose of rifampicin, the most important drug in this regimen, has been historically based on pra
Externí odkaz:
https://doaj.org/article/b00d0d8fa6eb43b4998799203014fdcc
Autor:
Laura Sibley, Andrew D. White, Charlotte Sarfas, Jennie Gullick, Fergus Gleeson, Faye Lanni, Simon Clark, Emma Rayner, Santiago Ferrer-Bazaga, Fatima Ortega-Muro, Laura Alameda, Joaquin Rullas, Veronica Sousa, Marisa Martinez, Inigo Angulo-Barturen, Adolfo Garcia, Juan José Vaquero, Henry E. Pertinez, Geraint Davies, Mike Dennis, Ann Williams, Sally Sharpe
Publikováno v:
Pharmaceutics, Vol 14, Iss 12, p 2666 (2022)
Innovative cross-over study designs were explored in non-human primate (NHP) studies to determine the value of this approach for the evaluation of drug efficacy against tuberculosis (TB). Firstly, the pharmacokinetics (PK) of each of the drugs Isonia
Externí odkaz:
https://doaj.org/article/de04d1d2aadf4dc2bc3352fe889680e3
Autor:
Marty Richardson, Jamie Kirkham, Kerry Dwan, Derek J. Sloan, Geraint Davies, Andrea L. Jorgensen
Publikováno v:
Systematic Reviews, Vol 7, Iss 1, Pp 1-15 (2018)
Abstract Background Treatment with anti-tuberculosis drugs may cause patients to experience serious adverse effects. Genetic factors, such as polymorphisms of CYP genes, may increase the likelihood of a patient experiencing such adverse drug reaction
Externí odkaz:
https://doaj.org/article/f384f6c7da7c4ed0ac743b8eddf81b6f
Autor:
Marty Chaplin, Jamie J Kirkham, Kerry Dwan, Derek J Sloan, Geraint Davies, Andrea L Jorgensen
Publikováno v:
PLoS Medicine, Vol 17, Iss 9, p e1003344 (2020)
BackgroundLarge sample sizes are often required to detect statistically significant associations between pharmacogenetic markers and treatment response. Meta-analysis may be performed to synthesize data from several studies, increasing sample size an
Externí odkaz:
https://doaj.org/article/85328ad116fc4f3586fe68505e04bd82
Autor:
Anneke van der Walt, Helmut Butzkueven, Robert K. Shin, Luciana Midaglia, Luca Capezzuto, Michael Lindemann, Geraint Davies, Lesley M. Butler, Cristina Costantino, Xavier Montalban
Publikováno v:
Brain Sciences, Vol 11, Iss 9, p 1247 (2021)
There is increasing interest in the development and deployment of digital solutions to improve patient care and facilitate monitoring in medical practice, e.g., by remote observation of disease symptoms in the patients’ home environment. Digital he
Externí odkaz:
https://doaj.org/article/6a896d504a084c93a65eb5bdb082b62d
Publikováno v:
Systematic Reviews, Vol 6, Iss 1, Pp 1-10 (2017)
Abstract Background Tuberculosis patients receiving anti-tuberculosis treatment may experience serious adverse drug reactions, such as hepatotoxicity. Genetic risk factors, such as polymorphisms of the NAT2, CYP2E1 and GSTM1 genes, may increase the r
Externí odkaz:
https://doaj.org/article/13a3406d06fc4e04932e8e6b5d02b9f1
Publikováno v:
PLoS Medicine, Vol 16, Iss 7, p e1002851 (2019)
Geraint Davies and colleagues discuss the potential for innovative early-phase clinical trial methods and technologies to reduce risk and speed up drug development for tuberculosis.
Externí odkaz:
https://doaj.org/article/fea8c39add12438baebd2cf4bef6c7ef
Autor:
Charles A. Peloquin, Geraint Davies
Publikováno v:
CLINICAL PHARMACOLOGY & THERAPEUTICS
Tuberculosis (TB) remains a leading cause of infectious death worldwide, and poverty is a major driver. Clinically, TB presents as "latent" TB and active TB disease, and the treatment for each is different. TB drugs can display "early bactericidal ac
Autor:
Hugh Adler, Susan Gould, Paul Hine, Luke B Snell, Waison Wong, Catherine F Houlihan, Jane C Osborne, Tommy Rampling, Mike BJ Beadsworth, Christopher JA Duncan, Jake Dunning, Tom E Fletcher, Ewan R Hunter, Michael Jacobs, Saye H Khoo, William Newsholme, David Porter, Robert J Porter, Libuše Ratcliffe, Matthias L Schmid, Malcolm G Semple, Anne J Tunbridge, Tom Wingfield, Nicholas M Price, Mike Abouyannis, Asma Al-Balushi, Stephen Aston, Robert Ball, Nicholas J Beeching, Thomas J Blanchard, Ffion Carlin, Geraint Davies, Angela Gillespie, Scott R Hicks, Marie-Claire Hoyle, Chinenye Ilozue, Luke Mair, Suzanne Marshall, Anne Neary, Emmanuel Nsutebu, Samantha Parker, Hannah Ryan, Lance Turtle, Chris Smith, Jon van Aartsen, Naomi F Walker, Stephen Woolley, Anu Chawla, Ian Hart, Anna Smielewska, Elizabeth Joekes, Cathryn Benson, Cheryl Brindley, Urmi Das, Chin K Eyton-Chong, Claire Gnanalingham, Clare Halfhide, Beatriz Larru, Sarah Mayell, Joanna McBride, Claire Oliver, Princy Paul, Andrew Riordan, Lekha Sridhar, Megan Storey, Audrey Abdul, Jennifer Abrahamsen, Breda Athan, Sanjay Bhagani, Colin S Brown, Oliver Carpenter, Ian Cropley, Kerrie Frost, Susan Hopkins, Jessica Joyce, Lucy Lamb, Adrian Lyons, Tabitha Mahungu, Stephen Mepham, Edina Mukwaira, Alison Rodger, Caroline Taylor, Simon Warren, Alan Williams, Debbie Levitt, Denise Allen, Jill Dixon, Adam Evans, Pauline McNicholas, Brendan Payne, D Ashley Price, Uli Schwab, Allison Sykes, Yusri Taha, Margaret Ward, Marieke Emonts, Stephen Owens, Alina Botgros, Sam T Douthwaite, Anna Goodman, Akish Luintel, Eithne MacMahon, Gaia Nebbia, Geraldine O'Hara, Joseph Parsons, Ashwin Sen, Daniel Stevenson, Tadgh Sullivan, Usman Taj, Claire van Nipsen tot Pannerden, Helen Winslow, Ewa Zatyka, Ekene Alozie-Otuka, Csaba Beviz, Yusupha Ceesay, Latchmin Gargee, Morloh Kabia, Hannah Mitchell, Shona Perkins, Mingaile Sasson, Kamal Sehmbey, Federico Tabios, Neil Wigglesworth, Emma J Aarons, Tim Brooks, Matthew Dryden, Jenna Furneaux, Barry Gibney, Jennifer Small, Elizabeth Truelove, Clare E Warrell, Richard Firth, Gemma Hobson, Christopher Johnson, Alison Dewynter, Sebastian Nixon, Oliver Spence, Joachim J Bugert, Dennis E Hruby
Background Cases of human monkeypox are rarely seen outside of west and central Africa. There are few data regarding viral kinetics or the duration of viral shedding and no licensed treatments. Two oral drugs, brincidofovir and tecovirimat, have been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9e287fd12f14777099c17c4a2cd3957
https://ora.ox.ac.uk/objects/uuid:b4702035-0ad4-4de0-a058-16fc519f15ab
https://ora.ox.ac.uk/objects/uuid:b4702035-0ad4-4de0-a058-16fc519f15ab
Autor:
Grant Theron, Karen R Steingart, Geraint Davies, Margaretha de Vos, Samantha Pillay, Samuel G Schumacher, Rob Warren, Marty Chaplin
Publikováno v:
Cochrane Database of Systematic Reviews
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
Cochrane Database Syst Rev
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
Cochrane Database Syst Rev
Background\ud The World Health Organization (WHO) End TB Strategy stresses universal access to drug susceptibility testing (DST). DST determines whether Mycobacterium tuberculosis bacteria are susceptible or resistant to drugs. Xpert MTB/XDR is a rap