α-Synuclein polymorphism determines oligodendroglial dysfunction

Autor: Christian Dienemann, So-Myeong Lee, Strohaeker T, Woojin S. Kim, Frieg B, Jung Bc, Panagiota Mavroeidi, Geraets Ja, G. F. Schroeder, Markus Zweckstetter, Maria Xilouri

Synucleinopathies, such as Parkinson’s disease (PD) and Multiple System Atrophy (MSA) are progressive and unremitting neurological diseases. For both PD and MSA, α-synuclein fibril inclusions inside brain cells are neuropathological hallmarks. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6bb61a06d21466fb63dbd3daf898eb3a
https://doi.org/10.1101/2021.07.09.451731

Self-assembling nanoscale systems

Autor: Geraets, James A.

Self-assembly is ubiquitous in different areas of science, for example in crystals and viruses, and also plays crucial roles in nanotechnology. Many commonalities link these self-assembling systems, in spite of their complexity and different length a

Externí odkaz: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.685234

The 3D structure of lipidic fibrils of α-synuclein.

Autor: Frieg B; Institute of Biological Information Processing (IBI-7: Structural Biochemistry) and JuStruct: Jülich Center for Structural Biology, Forschungszentrum Jülich, Jülich, Germany., Antonschmidt L; Department of NMR-Based Structural Biology, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany., Dienemann C; Department of Molecular Biology, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany., Geraets JA; Institute of Biological Information Processing (IBI-7: Structural Biochemistry) and JuStruct: Jülich Center for Structural Biology, Forschungszentrum Jülich, Jülich, Germany., Najbauer EE; Department of NMR-Based Structural Biology, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany., Matthes D; Department of Theoretical and Computational Biophysics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany., de Groot BL; Department of Theoretical and Computational Biophysics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany., Andreas LB; Department of NMR-Based Structural Biology, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany., Becker S; Department of NMR-Based Structural Biology, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany., Griesinger C; Department of NMR-Based Structural Biology, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany. cigr@mpinat.mpg.de.; Cluster of Excellence 'Multiscale Bioimaging: From Molecular Machines to Networks of Excitable Cells' (MBExC), University of Göttingen, Göttingen, Germany. cigr@mpinat.mpg.de., Schröder GF; Institute of Biological Information Processing (IBI-7: Structural Biochemistry) and JuStruct: Jülich Center for Structural Biology, Forschungszentrum Jülich, Jülich, Germany. gu.schroeder@fz-juelich.de.; Physics Department, Heinrich Heine University Düsseldorf, Düsseldorf, Germany. gu.schroeder@fz-juelich.de.

Publikováno v: Nature communications [Nat Commun] 2022 Nov 10; Vol. 13 (1), pp. 6810. Date of Electronic Publication: 2022 Nov 10.

Quaternary structure of patient-homogenate amplified α-synuclein fibrils modulates seeding of endogenous α-synuclein.

Autor: Frieg B; Institute of Biological Information Processing (IBI-7: Structural Biochemistry), Forschungszentrum Jülich GmbH, Wilhelm-Johnen-Straße, 52425, Jülich, Germany., Geraets JA; Institute of Biological Information Processing (IBI-7: Structural Biochemistry), Forschungszentrum Jülich GmbH, Wilhelm-Johnen-Straße, 52425, Jülich, Germany., Strohäker T; German Center for Neurodegenerative Diseases (DZNE), Von-Siebold-Str. 3a, 37075, Göttingen, Germany., Dienemann C; Department of Molecular Biology, Max Planck Institute for Multidisciplinary Sciences, Am Faßberg 11, 37077, Göttingen, Germany., Mavroeidi P; Center of Clinical, Experimental Surgery, & Translational Research, Biomedical Research Foundation of the Academy of Athens (BRFAA) 4, Soranou Efesiou Street, Athens, 11527, Greece., Jung BC; Department of Biomedical Sciences, Neuroscience Research Institute, College of Medicine, Seoul National University, Seoul, 03080, Korea.; Nutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA, 94720, USA., Kim WS; Brain and Mind Centre and School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.; School of Medical Sciences, University of New South Wales & Neuroscience Research Australia, Randwick, NSW, 2031, Australia., Lee SJ; Department of Biomedical Sciences, Neuroscience Research Institute, College of Medicine, Seoul National University, Seoul, 03080, Korea., Xilouri M; Center of Clinical, Experimental Surgery, & Translational Research, Biomedical Research Foundation of the Academy of Athens (BRFAA) 4, Soranou Efesiou Street, Athens, 11527, Greece., Zweckstetter M; German Center for Neurodegenerative Diseases (DZNE), Von-Siebold-Str. 3a, 37075, Göttingen, Germany. Markus.Zweckstetter@dzne.de.; Department for NMR-based Structural Biology, Max Planck Institute for Multidisciplinary Sciences, Am Faßberg 11, 37077, Göttingen, Germany. Markus.Zweckstetter@dzne.de., Schröder GF; Institute of Biological Information Processing (IBI-7: Structural Biochemistry), Forschungszentrum Jülich GmbH, Wilhelm-Johnen-Straße, 52425, Jülich, Germany. gu.schroeder@fz-juelich.de.; Physics Department, Heinrich Heine University Düsseldorf, Düsseldorf, Germany. gu.schroeder@fz-juelich.de.

Publikováno v: Communications biology [Commun Biol] 2022 Sep 30; Vol. 5 (1), pp. 1040. Date of Electronic Publication: 2022 Sep 30.

Integrating cryo-EM and NMR data.

Autor: Geraets JA; Institute of Biological Information Processing (IBI-7: Structural Biochemistry) and JuStruct, Jülich Center for Structural Biology, Forschungszentrum Jülich, 52425 Jülich, Germany., Pothula KR; Institute of Biological Information Processing (IBI-7: Structural Biochemistry) and JuStruct, Jülich Center for Structural Biology, Forschungszentrum Jülich, 52425 Jülich, Germany., Schröder GF; Institute of Biological Information Processing (IBI-7: Structural Biochemistry) and JuStruct, Jülich Center for Structural Biology, Forschungszentrum Jülich, 52425 Jülich, Germany; Physics Department, Heinrich-Heine-Universität Düsseldorf, 40225 Düsseldorf, Germany. Electronic address: gu.schroeder@fz-juelich.de.

Publikováno v: Current opinion in structural biology [Curr Opin Struct Biol] 2020 Apr; Vol. 61, pp. 173-181. Date of Electronic Publication: 2020 Feb 03.